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Intranasal spray medications for maintenance therapy of allergic rhinitis.
Am J Rhinol Allergy. 2015 Jul-Aug; 29(4):273-82.AJ

Abstract

BACKGROUND

Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR) by providing direct delivery of medication to the nasal mucosa, reducing the potential for systemic adverse effects, decreasing burden of disease, and improving quality of life.

OBJECTIVE

To review currently available intranasal sprays indicated for maintenance therapy of AR in the United States: intranasal antihistamines (INAH); intranasal corticosteroids (INCS); and MP-AzeFlu, a single formulation nasal spray of the INAH, azelastine hydrochloride, and the INCS, fluticasone propionate.

METHODS

MEDLINE searches were conducted to identify placebo-controlled studies of commercially available prescription nasal sprays at U.S.-approved doses and indications, and published after an earlier systematic review of AR treatment. Inclusion criteria were ≥20 subjects; duration of ≥2 weeks for seasonal (or episodic) AR, ≥4 weeks for perennial (or persistent) AR, and reporting a total nasal symptom score as a primary or secondary outcome.

RESULTS

Twenty studies met the inclusion criteria: 4 pediatric, 16 adult/adolescent. There were 4 perennial AR studies (381 children, 1607 adults) and 16 seasonal AR trials (3081 children, 6548 adults). In these studies, 2451 subjects (481 children, 1970 adults) received an INCS, 3001 (1116 children, 1885 adults) received an INAH, and 346 adult subjects received MP-AzeFlu. All active treatments were well tolerated and effective as measured by the reduction in nasal symptoms. Head-to-head comparisons were only available for MP-AzeFlu versus the individual active agent components. MP-AzeFlu provided significantly greater symptom relief than either azelastine or fluticasone propionate alone and with an onset starting at 30 minutes after the dose.

CONCLUSION

The most recent addition to intranasal sprays for the maintenance therapy of AR is MP-AzeFlu, a single formulation nasal spray of azelastine hydrochloride and fluticasone propionate in an advanced delivery system. Analysis of clinical data showed this to be the first new intranasal medication that provides greater clinical benefit than an INCS in treating AR.

Authors+Show Affiliations

Division of Basic Clinical Immunology, University of California Irvine, School of Medicine, and Allergy and Asthma Associates, Mission Viejo, California, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26132312

Citation

Berger, William E., and Eli O. Meltzer. "Intranasal Spray Medications for Maintenance Therapy of Allergic Rhinitis." American Journal of Rhinology & Allergy, vol. 29, no. 4, 2015, pp. 273-82.
Berger WE, Meltzer EO. Intranasal spray medications for maintenance therapy of allergic rhinitis. Am J Rhinol Allergy. 2015;29(4):273-82.
Berger, W. E., & Meltzer, E. O. (2015). Intranasal spray medications for maintenance therapy of allergic rhinitis. American Journal of Rhinology & Allergy, 29(4), 273-82. https://doi.org/10.2500/ajra.2015.29.4215
Berger WE, Meltzer EO. Intranasal Spray Medications for Maintenance Therapy of Allergic Rhinitis. Am J Rhinol Allergy. 2015;29(4):273-82. PubMed PMID: 26132312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intranasal spray medications for maintenance therapy of allergic rhinitis. AU - Berger,William E, AU - Meltzer,Eli O, Y1 - 2015/06/29/ PY - 2015/7/2/entrez PY - 2015/7/2/pubmed PY - 2016/5/12/medline SP - 273 EP - 82 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 29 IS - 4 N2 - BACKGROUND: Intranasal sprays are recommended as targeted therapy for allergic rhinitis (AR) by providing direct delivery of medication to the nasal mucosa, reducing the potential for systemic adverse effects, decreasing burden of disease, and improving quality of life. OBJECTIVE: To review currently available intranasal sprays indicated for maintenance therapy of AR in the United States: intranasal antihistamines (INAH); intranasal corticosteroids (INCS); and MP-AzeFlu, a single formulation nasal spray of the INAH, azelastine hydrochloride, and the INCS, fluticasone propionate. METHODS: MEDLINE searches were conducted to identify placebo-controlled studies of commercially available prescription nasal sprays at U.S.-approved doses and indications, and published after an earlier systematic review of AR treatment. Inclusion criteria were ≥20 subjects; duration of ≥2 weeks for seasonal (or episodic) AR, ≥4 weeks for perennial (or persistent) AR, and reporting a total nasal symptom score as a primary or secondary outcome. RESULTS: Twenty studies met the inclusion criteria: 4 pediatric, 16 adult/adolescent. There were 4 perennial AR studies (381 children, 1607 adults) and 16 seasonal AR trials (3081 children, 6548 adults). In these studies, 2451 subjects (481 children, 1970 adults) received an INCS, 3001 (1116 children, 1885 adults) received an INAH, and 346 adult subjects received MP-AzeFlu. All active treatments were well tolerated and effective as measured by the reduction in nasal symptoms. Head-to-head comparisons were only available for MP-AzeFlu versus the individual active agent components. MP-AzeFlu provided significantly greater symptom relief than either azelastine or fluticasone propionate alone and with an onset starting at 30 minutes after the dose. CONCLUSION: The most recent addition to intranasal sprays for the maintenance therapy of AR is MP-AzeFlu, a single formulation nasal spray of azelastine hydrochloride and fluticasone propionate in an advanced delivery system. Analysis of clinical data showed this to be the first new intranasal medication that provides greater clinical benefit than an INCS in treating AR. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/26132312/Intranasal_spray_medications_for_maintenance_therapy_of_allergic_rhinitis_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2015.29.4215?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -