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Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.
Int J Clin Pharmacol Ther Toxicol 1989; 27(12):588-92IJ

Abstract

The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children. Theophylline was given at a dose of 6 mg/kg orally on an empty stomach and the pharmacokinetic parameters were calculated from the estimated plasma concentration of theophylline. No significant difference in the elimination half-life (t1/2), volume of distribution (Vd), clearance (cl) and area under the time plasma curve (AUC) could be observed between the three pediatric age groups. Also, there was no influence of sex and nutritional status on the pharmacokinetic parameters. The notable observation was a 5-fold interindividual difference in the peak plasma concentration (Cmax) after a single dose.

Authors+Show Affiliations

Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2613392

Citation

Kumar, L, et al. "Theophylline Pharmacokinetics in Well-nourished and Malnourished Asthmatic Children." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 27, no. 12, 1989, pp. 588-92.
Kumar L, Garg SK, Singh S, et al. Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. Int J Clin Pharmacol Ther Toxicol. 1989;27(12):588-92.
Kumar, L., Garg, S. K., Singh, S., Lal, R., & Shukla, V. K. (1989). Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 27(12), pp. 588-92.
Kumar L, et al. Theophylline Pharmacokinetics in Well-nourished and Malnourished Asthmatic Children. Int J Clin Pharmacol Ther Toxicol. 1989;27(12):588-92. PubMed PMID: 2613392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. AU - Kumar,L, AU - Garg,S K, AU - Singh,S, AU - Lal,R, AU - Shukla,V K, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 588 EP - 92 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 27 IS - 12 N2 - The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children. Theophylline was given at a dose of 6 mg/kg orally on an empty stomach and the pharmacokinetic parameters were calculated from the estimated plasma concentration of theophylline. No significant difference in the elimination half-life (t1/2), volume of distribution (Vd), clearance (cl) and area under the time plasma curve (AUC) could be observed between the three pediatric age groups. Also, there was no influence of sex and nutritional status on the pharmacokinetic parameters. The notable observation was a 5-fold interindividual difference in the peak plasma concentration (Cmax) after a single dose. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/2613392/Theophylline_pharmacokinetics_in_well_nourished_and_malnourished_asthmatic_children_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -