Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.Int J Clin Pharmacol Ther Toxicol 1989; 27(12):588-92IJ
The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children. Theophylline was given at a dose of 6 mg/kg orally on an empty stomach and the pharmacokinetic parameters were calculated from the estimated plasma concentration of theophylline. No significant difference in the elimination half-life (t1/2), volume of distribution (Vd), clearance (cl) and area under the time plasma curve (AUC) could be observed between the three pediatric age groups. Also, there was no influence of sex and nutritional status on the pharmacokinetic parameters. The notable observation was a 5-fold interindividual difference in the peak plasma concentration (Cmax) after a single dose.