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A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov; 388(11):1129-40.NS

Abstract

Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset. Diabetes mellitus may cause this type of vulvar pain in several ways, so this study was conducted to evaluate streptozotocin-induced diabetes as a neuropathic pain model for vulvodynia in female rats. The presence of streptozotocin (50 mg/kg i.p.)-induced diabetes was initially verified by disclosure of pancreatic tissue degeneration, blood glucose elevation and body weight loss 5-29 days after a single treatment. Dynamic (shortened paw withdrawal latency to light brushing) and static (diminished von Frey filament threshold pressure) mechanical allodynia was then confirmed on the plantar foot surface. Subsequently, both static and dynamic vulvodynia was detected by application of the paradigm to the vulval region. Systemic gabapentin (75 mg/kg, i.p.) and topical gabapentin (10 % gel) were finally tested against allodynia and vulvodynia. Topical gabapentin and the control gel vehicle significantly increased paw withdrawal threshold in the case of the static allodynia model and also paw withdrawal latency in the model for dynamic allodynia when compared with the streptozotocin-pretreated group. Likewise, in the case of static and dynamic vulvodynia, there was a significant antivulvodynia effect of systemic and topical gabapentin treatment. These outcomes substantiate the value of this model not only for allodynia but also for vulvodynia, and this was corroborated by the findings not only with systemic but also with topical gabapentin.

Authors+Show Affiliations

Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan.Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan. fazal_subhan@upesh.edu.pk.Fulbright Graduate Student, Department of Pharmaceutical Sciences, College of Pharmacy, South, Dakota State University, Brookings, SD, 57007, USA.Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan.Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan.Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Ave., Cardiff, CF10 3NB, UK. sewell@cardiff.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26134846

Citation

Ali, Gowhar, et al. "A Streptozotocin-induced Diabetic Neuropathic Pain Model for Static or Dynamic Mechanical Allodynia and Vulvodynia: Validation Using Topical and Systemic Gabapentin." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 388, no. 11, 2015, pp. 1129-40.
Ali G, Subhan F, Abbas M, et al. A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(11):1129-40.
Ali, G., Subhan, F., Abbas, M., Zeb, J., Shahid, M., & Sewell, R. D. (2015). A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(11), 1129-40. https://doi.org/10.1007/s00210-015-1145-y
Ali G, et al. A Streptozotocin-induced Diabetic Neuropathic Pain Model for Static or Dynamic Mechanical Allodynia and Vulvodynia: Validation Using Topical and Systemic Gabapentin. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(11):1129-40. PubMed PMID: 26134846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. AU - Ali,Gowhar, AU - Subhan,Fazal, AU - Abbas,Muzaffar, AU - Zeb,Jehan, AU - Shahid,Muhammad, AU - Sewell,Robert D E, Y1 - 2015/07/03/ PY - 2014/08/26/received PY - 2015/06/10/accepted PY - 2015/7/3/entrez PY - 2015/7/3/pubmed PY - 2016/8/19/medline KW - Allodynia KW - Diabetic neuropathic pain KW - Gabapentin KW - Streptozotocin KW - Vulvodynia model SP - 1129 EP - 40 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 388 IS - 11 N2 - Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset. Diabetes mellitus may cause this type of vulvar pain in several ways, so this study was conducted to evaluate streptozotocin-induced diabetes as a neuropathic pain model for vulvodynia in female rats. The presence of streptozotocin (50 mg/kg i.p.)-induced diabetes was initially verified by disclosure of pancreatic tissue degeneration, blood glucose elevation and body weight loss 5-29 days after a single treatment. Dynamic (shortened paw withdrawal latency to light brushing) and static (diminished von Frey filament threshold pressure) mechanical allodynia was then confirmed on the plantar foot surface. Subsequently, both static and dynamic vulvodynia was detected by application of the paradigm to the vulval region. Systemic gabapentin (75 mg/kg, i.p.) and topical gabapentin (10 % gel) were finally tested against allodynia and vulvodynia. Topical gabapentin and the control gel vehicle significantly increased paw withdrawal threshold in the case of the static allodynia model and also paw withdrawal latency in the model for dynamic allodynia when compared with the streptozotocin-pretreated group. Likewise, in the case of static and dynamic vulvodynia, there was a significant antivulvodynia effect of systemic and topical gabapentin treatment. These outcomes substantiate the value of this model not only for allodynia but also for vulvodynia, and this was corroborated by the findings not only with systemic but also with topical gabapentin. SN - 1432-1912 UR - https://www.unboundmedicine.com/medline/citation/26134846/A_streptozotocin_induced_diabetic_neuropathic_pain_model_for_static_or_dynamic_mechanical_allodynia_and_vulvodynia:_validation_using_topical_and_systemic_gabapentin_ L2 - https://dx.doi.org/10.1007/s00210-015-1145-y DB - PRIME DP - Unbound Medicine ER -