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Lessons to be Learned from Recent Biosafety Incidents in the United States.
Isr Med Assoc J. 2015 May; 17(5):269-73.IM

Abstract

During recent months, the Centers for Disease Control and Prevention (CDC) announced the occurrence of three major biosafety incidents, raising serious concern about biosafety and biosecurity guideline implementation in the most prestigious agencies in the United States: the CDC, the National Institutes of Health (NIH) and the Federal Drug Administration (FDA). These lapses included: a) the mishandling of Bacillus anthracis spores potentially exposing dozens of employees to anthrax; b) the shipment of low pathogenic influenza virus unknowingly cross-contaminated with a highly pathogenic strain; and c) an inventory lapse of hundreds of samples of biological agents, including six vials of variola virus kept in a cold storage room for decades, unnoticed. In this review we present the published data on these events, report the CDC inquiry's main findings, and discuss the key lessons to be learnt to ensure safer scientific practice in biomedical and microbiological service and research laboratories.

Authors

Weiss S
No affiliation info available
Yitzhaki S
No affiliation info available
Shapira SC
No affiliation info available

MeSH

Bacillus anthracisBiohazard ReleaseBiomedical ResearchCenters for Disease Control and Prevention, U.S.Containment of BiohazardsGuidelines as TopicHumansLaboratoriesNational Institutes of Health (U.S.)Occupational ExposureOrthomyxoviridaeSafety ManagementSpecimen HandlingUnited StatesUnited States Food and Drug AdministrationVariola virus

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26137650

Citation

Weiss, Shay, et al. "Lessons to Be Learned From Recent Biosafety Incidents in the United States." The Israel Medical Association Journal : IMAJ, vol. 17, no. 5, 2015, pp. 269-73.
Weiss S, Yitzhaki S, Shapira SC. Lessons to be Learned from Recent Biosafety Incidents in the United States. Isr Med Assoc J. 2015;17(5):269-73.
Weiss, S., Yitzhaki, S., & Shapira, S. C. (2015). Lessons to be Learned from Recent Biosafety Incidents in the United States. The Israel Medical Association Journal : IMAJ, 17(5), 269-73.
Weiss S, Yitzhaki S, Shapira SC. Lessons to Be Learned From Recent Biosafety Incidents in the United States. Isr Med Assoc J. 2015;17(5):269-73. PubMed PMID: 26137650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lessons to be Learned from Recent Biosafety Incidents in the United States. AU - Weiss,Shay, AU - Yitzhaki,Shmuel, AU - Shapira,Shmuel C, PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2015/8/13/medline SP - 269 EP - 73 JF - The Israel Medical Association journal : IMAJ JO - Isr Med Assoc J VL - 17 IS - 5 N2 - During recent months, the Centers for Disease Control and Prevention (CDC) announced the occurrence of three major biosafety incidents, raising serious concern about biosafety and biosecurity guideline implementation in the most prestigious agencies in the United States: the CDC, the National Institutes of Health (NIH) and the Federal Drug Administration (FDA). These lapses included: a) the mishandling of Bacillus anthracis spores potentially exposing dozens of employees to anthrax; b) the shipment of low pathogenic influenza virus unknowingly cross-contaminated with a highly pathogenic strain; and c) an inventory lapse of hundreds of samples of biological agents, including six vials of variola virus kept in a cold storage room for decades, unnoticed. In this review we present the published data on these events, report the CDC inquiry's main findings, and discuss the key lessons to be learnt to ensure safer scientific practice in biomedical and microbiological service and research laboratories. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/26137650/Lessons_to_be_Learned_from_Recent_Biosafety_Incidents_in_the_United_States_ DB - PRIME DP - Unbound Medicine ER -