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An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines.
Org Biomol Chem. 2015 Aug 07; 13(29):7920-3.OB

Abstract

A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions.

Authors+Show Affiliations

School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, P. R. China. jtsun08@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26138437

Citation

Zhang, Sai, et al. "An Efficient Synthesis of Isoquinolines Via Rhodium-catalyzed Direct C-H Functionalization of Arylhydrazines." Organic & Biomolecular Chemistry, vol. 13, no. 29, 2015, pp. 7920-3.
Zhang S, Huang D, Xu G, et al. An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines. Org Biomol Chem. 2015;13(29):7920-3.
Zhang, S., Huang, D., Xu, G., Cao, S., Wang, R., Peng, S., & Sun, J. (2015). An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines. Organic & Biomolecular Chemistry, 13(29), 7920-3. https://doi.org/10.1039/c5ob01171j
Zhang S, et al. An Efficient Synthesis of Isoquinolines Via Rhodium-catalyzed Direct C-H Functionalization of Arylhydrazines. Org Biomol Chem. 2015 Aug 7;13(29):7920-3. PubMed PMID: 26138437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines. AU - Zhang,Sai, AU - Huang,Daorui, AU - Xu,Guangyang, AU - Cao,Shengyu, AU - Wang,Rong, AU - Peng,Shiyong, AU - Sun,Jiangtao, Y1 - 2015/07/03/ PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2016/5/18/medline SP - 7920 EP - 3 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 13 IS - 29 N2 - A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/26138437/An_efficient_synthesis_of_isoquinolines_via_rhodium_catalyzed_direct_C_H_functionalization_of_arylhydrazines_ L2 - https://doi.org/10.1039/c5ob01171j DB - PRIME DP - Unbound Medicine ER -
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