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Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks.
J Matern Fetal Neonatal Med. 2016; 29(7):1108-12.JM

Abstract

OBJECTIVE

The aim of this study was to identify adverse neonatal outcomes and identifies the predictors of adverse neonatal outcomes in premature rupture of membranes before 26 weeks.

METHODS

Data were collected between January 2005 and December 2011 from all pregnant women who presented preterm premature rupture of membranes (PPROM) between 18 and 26 complete weeks of gestation and were admitted to one of three Brazilian institutes. The adverse outcomes included mortality or the development of a severe morbidity during the length of stay in the neonatal intensive care unit (NICU). The descriptive statistics of the population were reported. A multiple logistic regression was performed for each predictor of neonatal adverse outcomes. The area under the receiver operating characteristics curves for the birth weight was calculated.

RESULTS

Composite adverse outcomes during the NICU stay occurred in 82.1% (n = 23) of the cases and included 33 (54%) neonatal deaths, 19 (67.8%) cases of retinopathy of prematurity (ROP), 13 (46.4%) cases of pulmonary hypoplasia (BPD), 8 (28.5%) cases of periventricular-intraventricular hemorrhage (PIH) and 3 (10.7%) cases of periventricular leukomalacia (PVL). Only 17.8% (n = 5) of the neonates survived without morbidity. The area under the curve for the birth weight was 0.90 (95% IC: 0.81-0.98) for the prediction of mortality.

CONCLUSIONS

PPROM before 26 weeks has a high morbidity and mortality, and the significant predictors of neonatal mortality and adverse outcomes were antibiotic prophylaxis, latency period, GA at birth and birth weight. Nevertheless, the only independent significant predictor of survival rate was birth weight.

Authors+Show Affiliations

a Hospital Federal Servidores do Estado, Departament of Obstetricia, Maternal-fetal Unit, Ministério da Saúde - Rio de Janeiro , Brazil . b Clínica Perinatal Barra , Rio de Janeiro , RJ , Brazil .b Clínica Perinatal Barra , Rio de Janeiro , RJ , Brazil . c Universidade Federal Fluminense , Niterói , RJ , Brazil , and.b Clínica Perinatal Barra , Rio de Janeiro , RJ , Brazil . d Department of Obstetrics , Instituto Fernandes Figueira/FIOCRUZ , Rio de Janeiro , RJ , Brazil.c Universidade Federal Fluminense , Niterói , RJ , Brazil , and.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26138545

Citation

Esteves, Juliana Silva, et al. "Neonatal Outcome in Women With Preterm Premature Rupture of Membranes (PPROM) Between 18 and 26 Weeks." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 29, no. 7, 2016, pp. 1108-12.
Esteves JS, de Sá RA, de Carvalho PR, et al. Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks. J Matern Fetal Neonatal Med. 2016;29(7):1108-12.
Esteves, J. S., de Sá, R. A., de Carvalho, P. R., & Coca Velarde, L. G. (2016). Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(7), 1108-12. https://doi.org/10.3109/14767058.2015.1035643
Esteves JS, et al. Neonatal Outcome in Women With Preterm Premature Rupture of Membranes (PPROM) Between 18 and 26 Weeks. J Matern Fetal Neonatal Med. 2016;29(7):1108-12. PubMed PMID: 26138545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal outcome in women with preterm premature rupture of membranes (PPROM) between 18 and 26 weeks. AU - Esteves,Juliana Silva, AU - de Sá,Renato Augusto Moreira, AU - de Carvalho,Paulo Roberto Nassar, AU - Coca Velarde,Luis Guillermo, Y1 - 2015/07/03/ PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2016/12/15/medline KW - Adverse neonatal outcomes KW - pre-viable rupture of membranes KW - predictors KW - single pregnancy SP - 1108 EP - 12 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 29 IS - 7 N2 - OBJECTIVE: The aim of this study was to identify adverse neonatal outcomes and identifies the predictors of adverse neonatal outcomes in premature rupture of membranes before 26 weeks. METHODS: Data were collected between January 2005 and December 2011 from all pregnant women who presented preterm premature rupture of membranes (PPROM) between 18 and 26 complete weeks of gestation and were admitted to one of three Brazilian institutes. The adverse outcomes included mortality or the development of a severe morbidity during the length of stay in the neonatal intensive care unit (NICU). The descriptive statistics of the population were reported. A multiple logistic regression was performed for each predictor of neonatal adverse outcomes. The area under the receiver operating characteristics curves for the birth weight was calculated. RESULTS: Composite adverse outcomes during the NICU stay occurred in 82.1% (n = 23) of the cases and included 33 (54%) neonatal deaths, 19 (67.8%) cases of retinopathy of prematurity (ROP), 13 (46.4%) cases of pulmonary hypoplasia (BPD), 8 (28.5%) cases of periventricular-intraventricular hemorrhage (PIH) and 3 (10.7%) cases of periventricular leukomalacia (PVL). Only 17.8% (n = 5) of the neonates survived without morbidity. The area under the curve for the birth weight was 0.90 (95% IC: 0.81-0.98) for the prediction of mortality. CONCLUSIONS: PPROM before 26 weeks has a high morbidity and mortality, and the significant predictors of neonatal mortality and adverse outcomes were antibiotic prophylaxis, latency period, GA at birth and birth weight. Nevertheless, the only independent significant predictor of survival rate was birth weight. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/26138545/Neonatal_outcome_in_women_with_preterm_premature_rupture_of_membranes__PPROM__between_18_and_26_weeks_ L2 - https://www.tandfonline.com/doi/full/10.3109/14767058.2015.1035643 DB - PRIME DP - Unbound Medicine ER -