Tags

Type your tag names separated by a space and hit enter

Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India.
Public Health Nutr. 2016 Apr; 19(5):861-71.PH

Abstract

OBJECTIVE

In India, national databases indicate anaemia prevalence of 80 % among 6-35-month-old children and 58 % among 36-59-month-old children. The present study aimed to characterise anaemia and the associated factors among infants and pre-schoolers living in rural India.

DESIGN

Multivariate logistic regression analysis of data collected prior to an intervention trial. Fe-deficiency with anaemia (IDA), Fe deficiency with no anaemia (IDNA) and anaemia without Fe deficiency were defined. Serum ferritin, soluble transferrin receptor (sTfR) and sTfR/log ferritin index were used to indicate Fe status.

SETTING

Twenty-six villages of Nalgonda district, Telangana, India. Data were collected in community sites. Participants Four hundred and seventy-six infants (aged 6-12 months), 316 pre-schoolers (aged 29-56 months) and their mothers.

RESULTS

Prevalence of anaemia among infants and pre-schoolers was 66·4 and 47·8 %, prevalence of IDA was 52·2 and 42·1 %, prevalence of IDNA was 22·2 and 29·8 %, prevalence of anaemia without Fe deficiency was 14·2 and 5·7 %. Among infants, anaemia was positively associated with maternal anaemia (OR=3·31; 95 % CI 2·10, 5·23; P<0·001), and sTfR/log ferritin index (OR=2·21; 95 % CI 1·39, 3·54; P=0·001). Among pre-schoolers, anaemia was positively associated with maternal anaemia (OR=3·77; 95 % CI 1·94, 7·30; P<0·001), sTfR/log ferritin index (OR=5·29; 95 % CI 2·67, 10·50; P<0·001), high C-reactive protein (OR=4·39; 95 % CI 1·91, 10·06, P<0·001) and young age (29-35 months: OR=1·92; 05 % CI 1·18, 3·13, P=0·009).

CONCLUSIONS

Anaemia prevalence continues to be high among infants and pre-schoolers in rural India. Based on sTfR/ferritin index, Fe deficiency is a major factor associated with anaemia. Anaemia is also associated with inflammation among pre-schoolers and with maternal anaemia among infants and pre-schoolers, illustrating the importance of understanding the aetiology of anaemia in designing effective control strategies.

Authors+Show Affiliations

1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.2Behavioural Sciences,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.3Biostatistics,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.4Clinical Studies,National Institute of Nutrition,Indian Council of Medical Research,Hyderabad,Telangana,India.1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.1Division of Micronutrient Research,National Institute of Nutrition,Indian Council of Medical Research,Jamai-Osmania PO, Tarnaka,Hyderabad - 500 007,Telangana,India.5Department of International Health,Johns Hopkins Bloomberg School of Public Health,Baltimore,MD,USA.6Department of Pediatrics,University of Maryland School of Medicine,Baltimore,MD,USA.7Micronutrient Initiative,Ottawa,Ontario,Canada.8The Mathile Institute for the Advancement of Human Nutrition,Dayton,OH,USA.6Department of Pediatrics,University of Maryland School of Medicine,Baltimore,MD,USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26139153

Citation

Nair, Krishnapillai Madhavan, et al. "Characterisation of Anaemia and Associated Factors Among Infants and Pre-schoolers From Rural India." Public Health Nutrition, vol. 19, no. 5, 2016, pp. 861-71.
Nair KM, Fernandez-Rao S, Nagalla B, et al. Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India. Public Health Nutr. 2016;19(5):861-71.
Nair, K. M., Fernandez-Rao, S., Nagalla, B., Kankipati, R. V., Punjal, R., Augustine, L. F., Hurley, K. M., Tilton, N., Harding, K. B., Reinhart, G., & Black, M. M. (2016). Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India. Public Health Nutrition, 19(5), 861-71. https://doi.org/10.1017/S1368980015002050
Nair KM, et al. Characterisation of Anaemia and Associated Factors Among Infants and Pre-schoolers From Rural India. Public Health Nutr. 2016;19(5):861-71. PubMed PMID: 26139153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterisation of anaemia and associated factors among infants and pre-schoolers from rural India. AU - Nair,Krishnapillai Madhavan, AU - Fernandez-Rao,Sylvia, AU - Nagalla,Balakrishna, AU - Kankipati,Radhakrishna Vijaya, AU - Punjal,Ravinder, AU - Augustine,Little Flower, AU - Hurley,Kristen M, AU - Tilton,Nicholas, AU - Harding,Kimberly B, AU - Reinhart,Greg, AU - Black,Maureen M, Y1 - 2015/07/03/ PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2016/12/24/medline KW - Anaemia KW - India KW - Infants KW - Pre-schoolers KW - Risk factors KW - sTfR/log ferritin index SP - 861 EP - 71 JF - Public health nutrition JO - Public Health Nutr VL - 19 IS - 5 N2 - OBJECTIVE: In India, national databases indicate anaemia prevalence of 80 % among 6-35-month-old children and 58 % among 36-59-month-old children. The present study aimed to characterise anaemia and the associated factors among infants and pre-schoolers living in rural India. DESIGN: Multivariate logistic regression analysis of data collected prior to an intervention trial. Fe-deficiency with anaemia (IDA), Fe deficiency with no anaemia (IDNA) and anaemia without Fe deficiency were defined. Serum ferritin, soluble transferrin receptor (sTfR) and sTfR/log ferritin index were used to indicate Fe status. SETTING: Twenty-six villages of Nalgonda district, Telangana, India. Data were collected in community sites. Participants Four hundred and seventy-six infants (aged 6-12 months), 316 pre-schoolers (aged 29-56 months) and their mothers. RESULTS: Prevalence of anaemia among infants and pre-schoolers was 66·4 and 47·8 %, prevalence of IDA was 52·2 and 42·1 %, prevalence of IDNA was 22·2 and 29·8 %, prevalence of anaemia without Fe deficiency was 14·2 and 5·7 %. Among infants, anaemia was positively associated with maternal anaemia (OR=3·31; 95 % CI 2·10, 5·23; P<0·001), and sTfR/log ferritin index (OR=2·21; 95 % CI 1·39, 3·54; P=0·001). Among pre-schoolers, anaemia was positively associated with maternal anaemia (OR=3·77; 95 % CI 1·94, 7·30; P<0·001), sTfR/log ferritin index (OR=5·29; 95 % CI 2·67, 10·50; P<0·001), high C-reactive protein (OR=4·39; 95 % CI 1·91, 10·06, P<0·001) and young age (29-35 months: OR=1·92; 05 % CI 1·18, 3·13, P=0·009). CONCLUSIONS: Anaemia prevalence continues to be high among infants and pre-schoolers in rural India. Based on sTfR/ferritin index, Fe deficiency is a major factor associated with anaemia. Anaemia is also associated with inflammation among pre-schoolers and with maternal anaemia among infants and pre-schoolers, illustrating the importance of understanding the aetiology of anaemia in designing effective control strategies. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/26139153/Characterisation_of_anaemia_and_associated_factors_among_infants_and_pre_schoolers_from_rural_India_ L2 - https://www.cambridge.org/core/product/identifier/S1368980015002050/type/journal_article DB - PRIME DP - Unbound Medicine ER -