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PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients.
Sci Rep. 2015 Jul 03; 5:11901.SR

Abstract

The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs738409 GG genotype carriage were 7.8% (44/563), 15.8% (58/367) and 19.3% (17/88) in patients with no (liver fat content < 5%), mild (5-33%) and moderate/severe (> 66%) hepatic steatosis, respectively (trend P < 0.001). Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557-3.515, P < 0.001). Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001). PNPLA3 genetic variants had minimal effects on hepatic steatosis among overweight or obese patients. Compared to patients with BMI < 24 kg/m(2)/non-GG genotype, those with BMI >24 kg/m(2)/GG genotype were more likely to have hepatic steatosis (OR/CI:3.87/2.292-6.524, P < 0.001). In conclusions, both PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients. However, the genetic effect was mainly restricted to non-obese patients.

Authors+Show Affiliations

Graguate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Department of Occupational Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Division of Gastroenterology and Hepatology, Chi-Mei Medical Center, Liouying, Tainan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan. Department of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.Division of General Surgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Faculty of Internal Medicine, School of Medicine, College of Medicine, and Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan. Institute of Biomedical Sciences, National Sun Yat-Sen University.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26139292

Citation

Huang, Chung-Feng, et al. "PNPLA3 Genetic Variants Determine Hepatic Steatosis in Non-obese Chronic Hepatitis C Patients." Scientific Reports, vol. 5, 2015, p. 11901.
Huang CF, Chen JJ, Yeh ML, et al. PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients. Sci Rep. 2015;5:11901.
Huang, C. F., Chen, J. J., Yeh, M. L., Huang, C. I., Hsieh, M. Y., Yang, H. L., Dai, C. Y., Huang, J. F., Lin, Z. Y., Chen, S. C., Chuang, W. L., Chen, Y. L., & Yu, M. L. (2015). PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients. Scientific Reports, 5, 11901. https://doi.org/10.1038/srep11901
Huang CF, et al. PNPLA3 Genetic Variants Determine Hepatic Steatosis in Non-obese Chronic Hepatitis C Patients. Sci Rep. 2015 Jul 3;5:11901. PubMed PMID: 26139292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients. AU - Huang,Chung-Feng, AU - Chen,Jyh-Jou, AU - Yeh,Ming-Lun, AU - Huang,Ching-I, AU - Hsieh,Ming-Yen, AU - Yang,Hua-Ling, AU - Dai,Chia-Yen, AU - Huang,Jee-Fu, AU - Lin,Zu-Yau, AU - Chen,Shinn-Cherng, AU - Chuang,Wan-Long, AU - Chen,Yao-Li, AU - Yu,Ming-Lung, Y1 - 2015/07/03/ PY - 2015/04/08/received PY - 2015/06/08/accepted PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2016/8/5/medline SP - 11901 EP - 11901 JF - Scientific reports JO - Sci Rep VL - 5 N2 - The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs738409 GG genotype carriage were 7.8% (44/563), 15.8% (58/367) and 19.3% (17/88) in patients with no (liver fat content < 5%), mild (5-33%) and moderate/severe (> 66%) hepatic steatosis, respectively (trend P < 0.001). Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557-3.515, P < 0.001). Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824-6.500, P < 0.001). PNPLA3 genetic variants had minimal effects on hepatic steatosis among overweight or obese patients. Compared to patients with BMI < 24 kg/m(2)/non-GG genotype, those with BMI >24 kg/m(2)/GG genotype were more likely to have hepatic steatosis (OR/CI:3.87/2.292-6.524, P < 0.001). In conclusions, both PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients. However, the genetic effect was mainly restricted to non-obese patients. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26139292/PNPLA3_genetic_variants_determine_hepatic_steatosis_in_non_obese_chronic_hepatitis_C_patients_ L2 - http://dx.doi.org/10.1038/srep11901 DB - PRIME DP - Unbound Medicine ER -