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Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.
World J Gastroenterol 2015; 21(24):7577-83WJ

Abstract

AIM

To investigate the efficacy and safety profile of pancreatic duct (PD) stent placement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).

METHODS

We performed a search of MEDLINE, EMBASE, and Cochrane Library to identify randomized controlled clinical trials of prophylactic PD stent placement after ERCP. RevMan 5 software provided by Cochrane was used for the heterogeneity and efficacy analyses, and a meta-analysis was performed for the data that showed homogeneity. Categorical data are presented as relative risks and 95% confidence intervals (CIs), and measurement data are presented as weighted mean differences and 95%CIs.

RESULTS

The incidence rates of severe pancreatitis, operation failure, complications and patient pain severity were analyzed. Data on pancreatitis incidence were reported in 14 of 15 trials. There was no significant heterogeneity between the trials (I(2) = 0%, P = 0.93). In the stent group, 49 of the 1233 patients suffered from PEP, compared to 133 of the 1277 patients in the no-stent group. The results of this meta-analysis indicate that it may be possible to prevent PEP by placing a PD stent.

CONCLUSION

PD stent placement can reduce postoperative hyperamylasemia and might be an effective and safe option to prevent PEP if the operation indications are well controlled.

Authors+Show Affiliations

Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.Jin-He Fan, Jun-Bo Qian, Ya-Min Wang, Cheng-Jin Zhao, Department of Gastroenterology, Nantong First People's Hospital, Nantong 226001, Jiangsu Province, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26140006

Citation

Fan, Jin-He, et al. "Updated Meta-analysis of Pancreatic Stent Placement in Preventing Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis." World Journal of Gastroenterology, vol. 21, no. 24, 2015, pp. 7577-83.
Fan JH, Qian JB, Wang YM, et al. Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastroenterol. 2015;21(24):7577-83.
Fan, J. H., Qian, J. B., Wang, Y. M., Shi, R. H., & Zhao, C. J. (2015). Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis. World Journal of Gastroenterology, 21(24), pp. 7577-83. doi:10.3748/wjg.v21.i24.7577.
Fan JH, et al. Updated Meta-analysis of Pancreatic Stent Placement in Preventing Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis. World J Gastroenterol. 2015 Jun 28;21(24):7577-83. PubMed PMID: 26140006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Updated meta-analysis of pancreatic stent placement in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis. AU - Fan,Jin-He, AU - Qian,Jun-Bo, AU - Wang,Ya-Min, AU - Shi,Rui-Hua, AU - Zhao,Cheng-Jin, PY - 2014/05/29/received PY - 2014/09/19/revised PY - 2015/01/21/accepted PY - 2015/7/4/entrez PY - 2015/7/4/pubmed PY - 2016/3/17/medline KW - Endoscopic retrograde cholangiopancreatography KW - Pancreatic stent placement KW - Pancreatitis KW - Post-endoscopic retrograde cholangiopancreatography pancreatitis SP - 7577 EP - 83 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 21 IS - 24 N2 - AIM: To investigate the efficacy and safety profile of pancreatic duct (PD) stent placement for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). METHODS: We performed a search of MEDLINE, EMBASE, and Cochrane Library to identify randomized controlled clinical trials of prophylactic PD stent placement after ERCP. RevMan 5 software provided by Cochrane was used for the heterogeneity and efficacy analyses, and a meta-analysis was performed for the data that showed homogeneity. Categorical data are presented as relative risks and 95% confidence intervals (CIs), and measurement data are presented as weighted mean differences and 95%CIs. RESULTS: The incidence rates of severe pancreatitis, operation failure, complications and patient pain severity were analyzed. Data on pancreatitis incidence were reported in 14 of 15 trials. There was no significant heterogeneity between the trials (I(2) = 0%, P = 0.93). In the stent group, 49 of the 1233 patients suffered from PEP, compared to 133 of the 1277 patients in the no-stent group. The results of this meta-analysis indicate that it may be possible to prevent PEP by placing a PD stent. CONCLUSION: PD stent placement can reduce postoperative hyperamylasemia and might be an effective and safe option to prevent PEP if the operation indications are well controlled. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26140006/Updated_meta_analysis_of_pancreatic_stent_placement_in_preventing_post_endoscopic_retrograde_cholangiopancreatography_pancreatitis_ L2 - http://www.wjgnet.com/1007-9327/full/v21/i24/7577.htm DB - PRIME DP - Unbound Medicine ER -