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Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition.
Neurosci Lett. 2015 Aug 18; 602:120-5.NL

Abstract

PTEN is a dual specificity phosphatase and is implicated in inflammation and apoptosis of cerebral ischemia and reperfusion (I/R) injury. Bisperoxovanadium (Bpv), a specific inhibitor of PTEN's phosphatase activity, has demonstrated powerful neuroprotective properties. We investigated the neuroprotective roles of Bpv in the rat model of middle cerebral artery occlusion (MCAO) cerebral I/R injury, and explored the modulation of inflammatory mediators and PI3K/Akt/GSK-3β pathways by Bpv. Our results showed that treatment with Bpv (0.2 mg/kg/day) significantly decreased neurological deficit scores at 7 days after MCAO and infarct volume at 4 days after MCAO. The IL-10 concentration was increased and TNF-α concentration was decreased in the ischemic boundary zone of the cerebral cortex at 4 days after MCAO by Bpv. Furthermore, Bpv (0.2 mg/kg/day) treatment significantly reduced PTEN mRNA and protein levels and increased PI3K, Akt and p-GSK-3β proteins expression in the ischemic boundary zone of the cerebral cortex at 4 days after MCAO. In conclusions, Bpv treatment demonstrates neuroprotective effects on cerebral ischemia and reperfusion injury of ischemic stroke rats and is associated with its modulation of inflammatory mediator production and up-regulation of PTEN downstream proteins PI3K, Akt and p-GSK-3β.

Authors+Show Affiliations

Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China.Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China. Electronic address: haodljs@163.com.Department of Neurology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, PR China.Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China.Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China.Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China.Department of Neurology, Wujin Hospital Affiliated to Jiangsu University, Changzhou 213002, Jiangsu, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26141612

Citation

Mao, Lun-Lin, et al. "Neuroprotective Effects of Bisperoxovanadium On Cerebral Ischemia By Inflammation Inhibition." Neuroscience Letters, vol. 602, 2015, pp. 120-5.
Mao LL, Hao DL, Mao XW, et al. Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition. Neurosci Lett. 2015;602:120-5.
Mao, L. L., Hao, D. L., Mao, X. W., Xu, Y. F., Huang, T. T., Wu, B. N., & Wang, L. H. (2015). Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition. Neuroscience Letters, 602, 120-5. https://doi.org/10.1016/j.neulet.2015.06.040
Mao LL, et al. Neuroprotective Effects of Bisperoxovanadium On Cerebral Ischemia By Inflammation Inhibition. Neurosci Lett. 2015 Aug 18;602:120-5. PubMed PMID: 26141612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition. AU - Mao,Lun-Lin, AU - Hao,Dong-Lin, AU - Mao,Xiao-Wei, AU - Xu,Yuan-Feng, AU - Huang,Ting-Ting, AU - Wu,Bo-Na, AU - Wang,Li-Hui, Y1 - 2015/06/30/ PY - 2015/04/27/received PY - 2015/06/12/revised PY - 2015/06/22/accepted PY - 2015/7/5/entrez PY - 2015/7/5/pubmed PY - 2015/10/29/medline KW - (GSK-3β) KW - Akt KW - Bisperoxovanadium (Bpv) KW - Glycogen synthase kinase 3β KW - Ischemic stroke KW - Middle cerebral artery occlusion (MCAO) KW - Phosphatidylinositol 3-kinase (PI3K) SP - 120 EP - 5 JF - Neuroscience letters JO - Neurosci Lett VL - 602 N2 - PTEN is a dual specificity phosphatase and is implicated in inflammation and apoptosis of cerebral ischemia and reperfusion (I/R) injury. Bisperoxovanadium (Bpv), a specific inhibitor of PTEN's phosphatase activity, has demonstrated powerful neuroprotective properties. We investigated the neuroprotective roles of Bpv in the rat model of middle cerebral artery occlusion (MCAO) cerebral I/R injury, and explored the modulation of inflammatory mediators and PI3K/Akt/GSK-3β pathways by Bpv. Our results showed that treatment with Bpv (0.2 mg/kg/day) significantly decreased neurological deficit scores at 7 days after MCAO and infarct volume at 4 days after MCAO. The IL-10 concentration was increased and TNF-α concentration was decreased in the ischemic boundary zone of the cerebral cortex at 4 days after MCAO by Bpv. Furthermore, Bpv (0.2 mg/kg/day) treatment significantly reduced PTEN mRNA and protein levels and increased PI3K, Akt and p-GSK-3β proteins expression in the ischemic boundary zone of the cerebral cortex at 4 days after MCAO. In conclusions, Bpv treatment demonstrates neuroprotective effects on cerebral ischemia and reperfusion injury of ischemic stroke rats and is associated with its modulation of inflammatory mediator production and up-regulation of PTEN downstream proteins PI3K, Akt and p-GSK-3β. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/26141612/Neuroprotective_effects_of_bisperoxovanadium_on_cerebral_ischemia_by_inflammation_inhibition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(15)30005-7 DB - PRIME DP - Unbound Medicine ER -