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Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1.
Eur J Vasc Endovasc Surg. 2015 Sep; 50(3):360-7.EJ

Abstract

OBJECTIVES

The aim was to study the association between venous disorders and leg symptoms in the population based cross sectional Bonn Vein Study 1 (BVS1).

METHODS

A total of 1,350 men and 1,722 women aged 18-79 years were enrolled into BVS1. Chronic venous insufficiency (CVI), varicose veins (VVs), and clinical classes (C-classes/CEAP [Clinical, Etiological, Anatomical, and Pathophysiological]) were determined by clinical and duplex investigation. Leg symptoms (heaviness, tightness, swelling, pain after standing or sitting, pain while walking, muscle cramps, itching, and restless legs) were assessed in a standardized interview. For 2,624 subjects (48.7% male) with complete information on venous disorders, relevant characteristics and information on at least one leg symptom, multivariate logistic regression analysis was performed.

RESULTS

More women (929/63.0%) reported at least one leg symptom within the last 4 weeks than men (560/48.7%). Prevalence of reported symptoms increased with age (45.4% of the 18-29 year olds, 73.9% of the 70-79 year olds). Leg symptoms were more frequent in obese and underweight subjects. As confirmed by clinical and duplex examination 22.6% had VV and 15.8% had CVI. VV (OR: 1.4; CI: 1.1-1.7) and CVI (OR: 1.8; CI: 1.3-2.3) were significantly associated with reporting at least one leg symptom. In particular, there was a positive association of VV and CVI with itching, feeling of heaviness, tightness, swelling, and pain after standing or sitting. C2-C6 showed a statistically significant association with feeling of heaviness, tightness, swelling, and itching, while for pain on walking and muscle cramps this was shifted towards C classes C3-C6 and C3-C4, respectively.

CONCLUSIONS

Venous disorders show significant associations with several leg symptoms. Itching, feeling of heaviness, or tightness seem to be more closely related than other symptoms. The associations between C classes and symptoms seem to be restricted to classes C2 or higher.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wrona M
Department of Dermatology, University of Bonn, Germany.
Jöckel KH
Institute of Medical Informatics, Biometry und Epidemiology, University of Essen, Germany.
Pannier F
Department of Dermatology, University of Cologne, & Private Practice, Bonn, Germany.
Bock E
Institute of Medical Informatics, Biometry und Epidemiology, University of Essen, Germany.
Hoffmann B
Medical Faculty, Deanery of the Medical School, Heinrich-Heine University of Düsseldorf, Germany; IUF Leibniz Research Institute for Environmental Medicine, Heinrich-Heine University of Düsseldorf, Germany.
Rabe E
Department of Dermatology, University of Bonn, Germany. Electronic address: Eberhard.Rabe@ukb.uni-bonn.de.

MeSH

AdolescentAdultAgedChronic DiseaseComorbidityCross-Sectional StudiesFemaleGermanyHumansLogistic ModelsLower ExtremityMaleMiddle AgedMultivariate AnalysisOdds RatioPain MeasurementPrevalencePrognosisRisk FactorsTime FactorsUltrasonography, Doppler, DuplexVaricose VeinsVenous InsufficiencyYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26141786

Citation

Wrona, M, et al. "Association of Venous Disorders With Leg Symptoms: Results From the Bonn Vein Study 1." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 50, no. 3, 2015, pp. 360-7.
Wrona M, Jöckel KH, Pannier F, et al. Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360-7.
Wrona, M., Jöckel, K. H., Pannier, F., Bock, E., Hoffmann, B., & Rabe, E. (2015). Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 50(3), 360-7. https://doi.org/10.1016/j.ejvs.2015.05.013
Wrona M, et al. Association of Venous Disorders With Leg Symptoms: Results From the Bonn Vein Study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360-7. PubMed PMID: 26141786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. AU - Wrona,M, AU - Jöckel,K-H, AU - Pannier,F, AU - Bock,E, AU - Hoffmann,B, AU - Rabe,E, Y1 - 2015/06/30/ PY - 2015/03/03/received PY - 2015/05/13/accepted PY - 2015/7/5/entrez PY - 2015/7/5/pubmed PY - 2015/11/17/medline KW - CEAP KW - Chronic venous insufficiency KW - Symptoms KW - Varicose veins KW - Venous disorders SP - 360 EP - 7 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 50 IS - 3 N2 - OBJECTIVES: The aim was to study the association between venous disorders and leg symptoms in the population based cross sectional Bonn Vein Study 1 (BVS1). METHODS: A total of 1,350 men and 1,722 women aged 18-79 years were enrolled into BVS1. Chronic venous insufficiency (CVI), varicose veins (VVs), and clinical classes (C-classes/CEAP [Clinical, Etiological, Anatomical, and Pathophysiological]) were determined by clinical and duplex investigation. Leg symptoms (heaviness, tightness, swelling, pain after standing or sitting, pain while walking, muscle cramps, itching, and restless legs) were assessed in a standardized interview. For 2,624 subjects (48.7% male) with complete information on venous disorders, relevant characteristics and information on at least one leg symptom, multivariate logistic regression analysis was performed. RESULTS: More women (929/63.0%) reported at least one leg symptom within the last 4 weeks than men (560/48.7%). Prevalence of reported symptoms increased with age (45.4% of the 18-29 year olds, 73.9% of the 70-79 year olds). Leg symptoms were more frequent in obese and underweight subjects. As confirmed by clinical and duplex examination 22.6% had VV and 15.8% had CVI. VV (OR: 1.4; CI: 1.1-1.7) and CVI (OR: 1.8; CI: 1.3-2.3) were significantly associated with reporting at least one leg symptom. In particular, there was a positive association of VV and CVI with itching, feeling of heaviness, tightness, swelling, and pain after standing or sitting. C2-C6 showed a statistically significant association with feeling of heaviness, tightness, swelling, and itching, while for pain on walking and muscle cramps this was shifted towards C classes C3-C6 and C3-C4, respectively. CONCLUSIONS: Venous disorders show significant associations with several leg symptoms. Itching, feeling of heaviness, or tightness seem to be more closely related than other symptoms. The associations between C classes and symptoms seem to be restricted to classes C2 or higher. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/26141786/Association_of_Venous_Disorders_with_Leg_Symptoms:_Results_from_the_Bonn_Vein_Study_1_ DB - PRIME DP - Unbound Medicine ER -