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Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1.

Abstract

OBJECTIVES

The aim was to study the association between venous disorders and leg symptoms in the population based cross sectional Bonn Vein Study 1 (BVS1).

METHODS

A total of 1,350 men and 1,722 women aged 18-79 years were enrolled into BVS1. Chronic venous insufficiency (CVI), varicose veins (VVs), and clinical classes (C-classes/CEAP [Clinical, Etiological, Anatomical, and Pathophysiological]) were determined by clinical and duplex investigation. Leg symptoms (heaviness, tightness, swelling, pain after standing or sitting, pain while walking, muscle cramps, itching, and restless legs) were assessed in a standardized interview. For 2,624 subjects (48.7% male) with complete information on venous disorders, relevant characteristics and information on at least one leg symptom, multivariate logistic regression analysis was performed.

RESULTS

More women (929/63.0%) reported at least one leg symptom within the last 4 weeks than men (560/48.7%). Prevalence of reported symptoms increased with age (45.4% of the 18-29 year olds, 73.9% of the 70-79 year olds). Leg symptoms were more frequent in obese and underweight subjects. As confirmed by clinical and duplex examination 22.6% had VV and 15.8% had CVI. VV (OR: 1.4; CI: 1.1-1.7) and CVI (OR: 1.8; CI: 1.3-2.3) were significantly associated with reporting at least one leg symptom. In particular, there was a positive association of VV and CVI with itching, feeling of heaviness, tightness, swelling, and pain after standing or sitting. C2-C6 showed a statistically significant association with feeling of heaviness, tightness, swelling, and itching, while for pain on walking and muscle cramps this was shifted towards C classes C3-C6 and C3-C4, respectively.

CONCLUSIONS

Venous disorders show significant associations with several leg symptoms. Itching, feeling of heaviness, or tightness seem to be more closely related than other symptoms. The associations between C classes and symptoms seem to be restricted to classes C2 or higher.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, University of Bonn, Germany.

    ,

    Institute of Medical Informatics, Biometry und Epidemiology, University of Essen, Germany.

    ,

    Department of Dermatology, University of Cologne, & Private Practice, Bonn, Germany.

    ,

    Institute of Medical Informatics, Biometry und Epidemiology, University of Essen, Germany.

    ,

    Medical Faculty, Deanery of the Medical School, Heinrich-Heine University of Düsseldorf, Germany; IUF Leibniz Research Institute for Environmental Medicine, Heinrich-Heine University of Düsseldorf, Germany.

    Department of Dermatology, University of Bonn, Germany. Electronic address: Eberhard.Rabe@ukb.uni-bonn.de.

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Chronic Disease
    Comorbidity
    Cross-Sectional Studies
    Female
    Germany
    Humans
    Logistic Models
    Lower Extremity
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Pain Measurement
    Prevalence
    Prognosis
    Risk Factors
    Time Factors
    Ultrasonography, Doppler, Duplex
    Varicose Veins
    Venous Insufficiency
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26141786

    Citation

    Wrona, M, et al. "Association of Venous Disorders With Leg Symptoms: Results From the Bonn Vein Study 1." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 50, no. 3, 2015, pp. 360-7.
    Wrona M, Jöckel KH, Pannier F, et al. Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360-7.
    Wrona, M., Jöckel, K. H., Pannier, F., Bock, E., Hoffmann, B., & Rabe, E. (2015). Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 50(3), pp. 360-7. doi:10.1016/j.ejvs.2015.05.013.
    Wrona M, et al. Association of Venous Disorders With Leg Symptoms: Results From the Bonn Vein Study 1. Eur J Vasc Endovasc Surg. 2015;50(3):360-7. PubMed PMID: 26141786.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. AU - Wrona,M, AU - Jöckel,K-H, AU - Pannier,F, AU - Bock,E, AU - Hoffmann,B, AU - Rabe,E, Y1 - 2015/06/30/ PY - 2015/03/03/received PY - 2015/05/13/accepted PY - 2015/7/5/entrez PY - 2015/7/5/pubmed PY - 2015/11/17/medline KW - CEAP KW - Chronic venous insufficiency KW - Symptoms KW - Varicose veins KW - Venous disorders SP - 360 EP - 7 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 50 IS - 3 N2 - OBJECTIVES: The aim was to study the association between venous disorders and leg symptoms in the population based cross sectional Bonn Vein Study 1 (BVS1). METHODS: A total of 1,350 men and 1,722 women aged 18-79 years were enrolled into BVS1. Chronic venous insufficiency (CVI), varicose veins (VVs), and clinical classes (C-classes/CEAP [Clinical, Etiological, Anatomical, and Pathophysiological]) were determined by clinical and duplex investigation. Leg symptoms (heaviness, tightness, swelling, pain after standing or sitting, pain while walking, muscle cramps, itching, and restless legs) were assessed in a standardized interview. For 2,624 subjects (48.7% male) with complete information on venous disorders, relevant characteristics and information on at least one leg symptom, multivariate logistic regression analysis was performed. RESULTS: More women (929/63.0%) reported at least one leg symptom within the last 4 weeks than men (560/48.7%). Prevalence of reported symptoms increased with age (45.4% of the 18-29 year olds, 73.9% of the 70-79 year olds). Leg symptoms were more frequent in obese and underweight subjects. As confirmed by clinical and duplex examination 22.6% had VV and 15.8% had CVI. VV (OR: 1.4; CI: 1.1-1.7) and CVI (OR: 1.8; CI: 1.3-2.3) were significantly associated with reporting at least one leg symptom. In particular, there was a positive association of VV and CVI with itching, feeling of heaviness, tightness, swelling, and pain after standing or sitting. C2-C6 showed a statistically significant association with feeling of heaviness, tightness, swelling, and itching, while for pain on walking and muscle cramps this was shifted towards C classes C3-C6 and C3-C4, respectively. CONCLUSIONS: Venous disorders show significant associations with several leg symptoms. Itching, feeling of heaviness, or tightness seem to be more closely related than other symptoms. The associations between C classes and symptoms seem to be restricted to classes C2 or higher. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/26141786/Association_of_Venous_Disorders_with_Leg_Symptoms:_Results_from_the_Bonn_Vein_Study_1_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(15)00333-0 DB - PRIME DP - Unbound Medicine ER -