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Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study.
Ann Saudi Med 2015 Jan-Feb; 35(1):19-22AS

Abstract

BACKGROUND

Despite the extensive reporting of pediatric ulcerative colitis (UC) from industrialized developed countries, reports from developing countries are limited to small-case series from single centers. The objective of our large multicenter study was to determine the clinical, laboratory, endoscopic characteristics of UC in children from a developing country, Saudi Arabia.

DESIGN AND SETTINGS

A retrospective study of children diagnosed with UC under the age of 18 years during the period from 2003 to 2012.

METHODS

Patients enrolled from 15 medical centers from different regions in Saudi Arabia. A unified database collection form specifically designed for this study was completed by all participating centers.

RESULTS

A total of 188 children were diagnosed with UC during the study period (97 males [51.6%] and 91 females [48.4%]). The mean age at diagnosis was 9.1 years, and the mean duration of symptoms before diagnosis was 8.7 months. Consanguinity was present in 57 cases (32.6%), and the family history of inflammatory bowel disease (IBD) was noted in 16 cases (9%). The most common clinical presentation was blood in stool (90%), followed by diarrhea (86%) and abdominal pain (62%). Laboratory investigations revealed elevated erythrocyte sedimentation rate (82%), anemia (75%), thrombocytosis (72%), and hypoalbuminemia (33%). The extent of the disease was pan colonic in 46.1%, and confined to left side of colon and rectum in 23% and 9.6% of the cases, respectively.

CONCLUSION

This demographically pediatric IBD retrospective study revealed age-related variation in the distribution of IBD. Clinical presentation, with a high prevalence of positive consanguinity and positive family history, was noted in young patients with UC. The data from this study indicate that UC is increasingly recognized in Saudi Arabia and show many similarities to data from North America and Europe.

Authors+Show Affiliations

Dr. Khalid AlSaleem, MBC 58 Department of Pediatrics,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211,, Saudi Arabia, T: 966505445487, ksaleem@kfshrc.edu.sa.No affiliation info availableNo affiliation info availableDr. Khalid AlSaleem, MBC 58 Department of Pediatrics,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211,, Saudi Arabia, T: 966505445487, ksaleem@kfshrc.edu.sa.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26142933

Citation

AlSaleem, Khalid, et al. "Characteristics of Pediatric Ulcerative Colitis in Saudi Arabia: a Multicenter National Study." Annals of Saudi Medicine, vol. 35, no. 1, 2015, pp. 19-22.
AlSaleem K, El Mouzan MI, Saadah OI, et al. Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. Ann Saudi Med. 2015;35(1):19-22.
AlSaleem, K., El Mouzan, M. I., Saadah, O. I., AlSaleem, B., Al-Hussaini, A., Hassosa, M., ... El Edreesi, M. (2015). Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. Annals of Saudi Medicine, 35(1), pp. 19-22. doi:10.5144/0256-4947.2015.19.
AlSaleem K, et al. Characteristics of Pediatric Ulcerative Colitis in Saudi Arabia: a Multicenter National Study. Ann Saudi Med. 2015;35(1):19-22. PubMed PMID: 26142933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. AU - AlSaleem,Khalid, AU - El Mouzan,Mohammad Issa, AU - Saadah,Omar I, AU - AlSaleem,Bader, AU - Al-Hussaini,Abdulrahman, AU - Hassosa,Mohammed, AU - Ali,Al-Mehaidib, AU - Banemai,Mohammed Othman, AU - Halaby,Hana, AU - El Edreesi,Mohammed, PY - 2015/7/6/entrez PY - 2015/7/6/pubmed PY - 2016/3/24/medline SP - 19 EP - 22 JF - Annals of Saudi medicine JO - Ann Saudi Med VL - 35 IS - 1 N2 - BACKGROUND: Despite the extensive reporting of pediatric ulcerative colitis (UC) from industrialized developed countries, reports from developing countries are limited to small-case series from single centers. The objective of our large multicenter study was to determine the clinical, laboratory, endoscopic characteristics of UC in children from a developing country, Saudi Arabia. DESIGN AND SETTINGS: A retrospective study of children diagnosed with UC under the age of 18 years during the period from 2003 to 2012. METHODS: Patients enrolled from 15 medical centers from different regions in Saudi Arabia. A unified database collection form specifically designed for this study was completed by all participating centers. RESULTS: A total of 188 children were diagnosed with UC during the study period (97 males [51.6%] and 91 females [48.4%]). The mean age at diagnosis was 9.1 years, and the mean duration of symptoms before diagnosis was 8.7 months. Consanguinity was present in 57 cases (32.6%), and the family history of inflammatory bowel disease (IBD) was noted in 16 cases (9%). The most common clinical presentation was blood in stool (90%), followed by diarrhea (86%) and abdominal pain (62%). Laboratory investigations revealed elevated erythrocyte sedimentation rate (82%), anemia (75%), thrombocytosis (72%), and hypoalbuminemia (33%). The extent of the disease was pan colonic in 46.1%, and confined to left side of colon and rectum in 23% and 9.6% of the cases, respectively. CONCLUSION: This demographically pediatric IBD retrospective study revealed age-related variation in the distribution of IBD. Clinical presentation, with a high prevalence of positive consanguinity and positive family history, was noted in young patients with UC. The data from this study indicate that UC is increasingly recognized in Saudi Arabia and show many similarities to data from North America and Europe. SN - 0975-4466 UR - https://www.unboundmedicine.com/medline/citation/26142933/Characteristics_of_pediatric_ulcerative_colitis_in_Saudi_Arabia:_a_multicenter_national_study_ L2 - http://www.annsaudimed.net/pdf/35/1/19 DB - PRIME DP - Unbound Medicine ER -