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Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease).
J Neurol Neurosurg Psychiatry. 1989 Dec; 52(12):1337-44.JN

Abstract

Formalin-fixed brain slices from four cases of subcortical arteriosclerotic encephalopathy in which a firm diagnosis could be made both clinically and pathologically have been studied by magnetic resonance imaging (MRI). The slices were subsequently embedded in paraffin-wax or celloidin and sections were cut in the same plane as the MRI slices. There was a good correlation between the extent and severity of the abnormal MRI signal and the pathological changes. Areas of diffuse MRI abnormality corresponded with areas of axonal and myelin loss with gliosis, and small "lacune"-like lesions corresponded with lacunar infarcts histologically. Sparing of the subcortical U-fibres was seen histologically and on MRI. The abnormal signal probably originates from increased tissue water attributable to gliosis and an expanded extracellular space.

Authors+Show Affiliations

Maida Vale Hospital for Nervous Diseases, London, England.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2614428

Citation

Révész, T, et al. "Pathological Findings Correlated With Magnetic Resonance Imaging in Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease)." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 52, no. 12, 1989, pp. 1337-44.
Révész T, Hawkins CP, du Boulay EP, et al. Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). J Neurol Neurosurg Psychiatry. 1989;52(12):1337-44.
Révész, T., Hawkins, C. P., du Boulay, E. P., Barnard, R. O., & McDonald, W. I. (1989). Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). Journal of Neurology, Neurosurgery, and Psychiatry, 52(12), 1337-44.
Révész T, et al. Pathological Findings Correlated With Magnetic Resonance Imaging in Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease). J Neurol Neurosurg Psychiatry. 1989;52(12):1337-44. PubMed PMID: 2614428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). AU - Révész,T, AU - Hawkins,C P, AU - du Boulay,E P, AU - Barnard,R O, AU - McDonald,W I, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 1337 EP - 44 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatry VL - 52 IS - 12 N2 - Formalin-fixed brain slices from four cases of subcortical arteriosclerotic encephalopathy in which a firm diagnosis could be made both clinically and pathologically have been studied by magnetic resonance imaging (MRI). The slices were subsequently embedded in paraffin-wax or celloidin and sections were cut in the same plane as the MRI slices. There was a good correlation between the extent and severity of the abnormal MRI signal and the pathological changes. Areas of diffuse MRI abnormality corresponded with areas of axonal and myelin loss with gliosis, and small "lacune"-like lesions corresponded with lacunar infarcts histologically. Sparing of the subcortical U-fibres was seen histologically and on MRI. The abnormal signal probably originates from increased tissue water attributable to gliosis and an expanded extracellular space. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/2614428/Pathological_findings_correlated_with_magnetic_resonance_imaging_in_subcortical_arteriosclerotic_encephalopathy__Binswanger's_disease__ L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=2614428 DB - PRIME DP - Unbound Medicine ER -