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Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature.

Abstract

A comparative experiment with Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) postsmolts was conducted over 35 days to provide insight into how growth, respiration, energy metabolism and the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) system are regulated at elevated sea temperatures. Rainbow trout grew better than Atlantic salmon, and did not show reduced growth at 19 °C. Rainbow trout kept at 19 °C had increased blood hemoglobin concentration compared to rainbow trout kept at 13 °C, while salmon did not show the same hemoglobin response due to increased temperature. Both species showed reduced length growth and decreased muscle glycogen stores at 19 °C. Circulating IGF-1 concentration was higher in rainbow trout than in Atlantic salmon, but was not affected by temperature in either species. Plasma IGF-binding protein 1b (IGFBP-1b) concentration was reduced in Atlantic salmon reared at 19 °C after 15 days but increased in rainbow trout at 19 °C after 35 days. The igfbp1b mRNA level in liver showed a positive correlation to plasma concentrations of glucose and IGFBP-1b, suggesting involvement of this binding protein in carbohydrate metabolism at 19 °C. At this temperature muscle igfbp1a mRNA was down-regulated in both species. The muscle expression of this binding protein correlated negatively with muscle igf1 and length growth. The plasma IGFBP-1b concentration and igfbp1b and igfbp1a expression suggests reduced muscle igf1 signaling at elevated temperature leading to glucose allostasis, and that time course is species specific due to higher thermal tolerance in rainbow trout.

Authors+Show Affiliations

National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Nordnes, N-5817 Bergen, Norway. Electronic address: ernst.hevroy@ewos.com.University of Arkansas, Department of Biological Science, SCEN 601, Fayetteville, AR 72701 USA.National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Nordnes, N-5817 Bergen, Norway.Institute of Marine Research, Matre Research Station, N-5984 Matredal Norway.Hokkaido University, Faculty of Fisheries Sciences, 3-1-1 Minato, Hakodate, Hokkaido 041-8611 Japan.Institute of Marine Research, Matre Research Station, N-5984 Matredal Norway.National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Nordnes, N-5817 Bergen, Norway; University of Bergen, Department of Biology, Bergen Norway; Skretting Aquaculture Research Center, PO Box 48, N-4001 Stavanger Norway.National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Nordnes, N-5817 Bergen, Norway.National Institute of Nutrition and Seafood Research (NIFES), PO Box 2029, Nordnes, N-5817 Bergen, Norway.Hokkaido University, Faculty of Fisheries Sciences, 3-1-1 Minato, Hakodate, Hokkaido 041-8611 Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26144599

Citation

Hevrøy, Ernst M., et al. "Role of the GH-IGF-1 System in Atlantic Salmon and Rainbow Trout Postsmolts at Elevated Water Temperature." Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, vol. 188, 2015, pp. 127-38.
Hevrøy EM, Tipsmark CK, Remø SC, et al. Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature. Comp Biochem Physiol, Part A Mol Integr Physiol. 2015;188:127-38.
Hevrøy, E. M., Tipsmark, C. K., Remø, S. C., Hansen, T., Fukuda, M., Torgersen, T., ... Shimizu, M. (2015). Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 188, pp. 127-38. doi:10.1016/j.cbpa.2015.06.030.
Hevrøy EM, et al. Role of the GH-IGF-1 System in Atlantic Salmon and Rainbow Trout Postsmolts at Elevated Water Temperature. Comp Biochem Physiol, Part A Mol Integr Physiol. 2015;188:127-38. PubMed PMID: 26144599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the GH-IGF-1 system in Atlantic salmon and rainbow trout postsmolts at elevated water temperature. AU - Hevrøy,Ernst M, AU - Tipsmark,Christian K, AU - Remø,Sofie C, AU - Hansen,Tom, AU - Fukuda,Miki, AU - Torgersen,Thomas, AU - Vikeså,Vibeke, AU - Olsvik,Pål A, AU - Waagbø,Rune, AU - Shimizu,Munetaka, Y1 - 2015/07/03/ PY - 2015/01/27/received PY - 2015/06/24/revised PY - 2015/06/24/accepted PY - 2015/7/7/entrez PY - 2015/7/7/pubmed PY - 2016/6/1/medline KW - Climate KW - GH-IGF system KW - Hemoglobin KW - IGFBP-1 KW - Oxygen consumption KW - Salmonids SP - 127 EP - 38 JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology JO - Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. VL - 188 N2 - A comparative experiment with Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) postsmolts was conducted over 35 days to provide insight into how growth, respiration, energy metabolism and the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) system are regulated at elevated sea temperatures. Rainbow trout grew better than Atlantic salmon, and did not show reduced growth at 19 °C. Rainbow trout kept at 19 °C had increased blood hemoglobin concentration compared to rainbow trout kept at 13 °C, while salmon did not show the same hemoglobin response due to increased temperature. Both species showed reduced length growth and decreased muscle glycogen stores at 19 °C. Circulating IGF-1 concentration was higher in rainbow trout than in Atlantic salmon, but was not affected by temperature in either species. Plasma IGF-binding protein 1b (IGFBP-1b) concentration was reduced in Atlantic salmon reared at 19 °C after 15 days but increased in rainbow trout at 19 °C after 35 days. The igfbp1b mRNA level in liver showed a positive correlation to plasma concentrations of glucose and IGFBP-1b, suggesting involvement of this binding protein in carbohydrate metabolism at 19 °C. At this temperature muscle igfbp1a mRNA was down-regulated in both species. The muscle expression of this binding protein correlated negatively with muscle igf1 and length growth. The plasma IGFBP-1b concentration and igfbp1b and igfbp1a expression suggests reduced muscle igf1 signaling at elevated temperature leading to glucose allostasis, and that time course is species specific due to higher thermal tolerance in rainbow trout. SN - 1531-4332 UR - https://www.unboundmedicine.com/medline/citation/26144599/Role_of_the_GH_IGF_1_system_in_Atlantic_salmon_and_rainbow_trout_postsmolts_at_elevated_water_temperature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1095-6433(15)00191-9 DB - PRIME DP - Unbound Medicine ER -