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Accuracy of anorectal manometry in the diagnosis of Hirschsprung's disease.
J Pediatr Gastroenterol Nutr. 1989 Oct; 9(3):342-6.JP

Abstract

The value of anorectal manometry as a diagnostic tool for Hirschsprung's disease (HD) was assessed in 50 children presenting with chronic constipation. Anorectal manometric studies and rectal biopsy were performed on all children. Biopsy specimens were stained with hematoxylin and eosin and serial sections were examined for ganglion cells. Forty-five children had concordant manometric and histologic results, 15 of whom were positive for HD and 30 negative. In five children, the results were discordant. Using histologic aganglionosis as the reference point for the final diagnosis of HD, the overall accuracy of anorectal manometry as a discriminative test was 90.0%. The sensitivity, specificity, and positive and negative predictive values of manometric studies for the diagnosis of HD were 0.79, 0.97, 0.94, and 0.88, respectively. Factors responsible for the inaccuracies of manometric studies are discussed.

Authors+Show Affiliations

Department of Paediatrics, National University of Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2614621

Citation

Low, P S., et al. "Accuracy of Anorectal Manometry in the Diagnosis of Hirschsprung's Disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 9, no. 3, 1989, pp. 342-6.
Low PS, Quak SH, Prabhakaran K, et al. Accuracy of anorectal manometry in the diagnosis of Hirschsprung's disease. J Pediatr Gastroenterol Nutr. 1989;9(3):342-6.
Low, P. S., Quak, S. H., Prabhakaran, K., Joseph, V. T., Chiang, G. S., & Aiyathurai, E. J. (1989). Accuracy of anorectal manometry in the diagnosis of Hirschsprung's disease. Journal of Pediatric Gastroenterology and Nutrition, 9(3), 342-6.
Low PS, et al. Accuracy of Anorectal Manometry in the Diagnosis of Hirschsprung's Disease. J Pediatr Gastroenterol Nutr. 1989;9(3):342-6. PubMed PMID: 2614621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accuracy of anorectal manometry in the diagnosis of Hirschsprung's disease. AU - Low,P S, AU - Quak,S H, AU - Prabhakaran,K, AU - Joseph,V T, AU - Chiang,G S, AU - Aiyathurai,E J, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 342 EP - 6 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 9 IS - 3 N2 - The value of anorectal manometry as a diagnostic tool for Hirschsprung's disease (HD) was assessed in 50 children presenting with chronic constipation. Anorectal manometric studies and rectal biopsy were performed on all children. Biopsy specimens were stained with hematoxylin and eosin and serial sections were examined for ganglion cells. Forty-five children had concordant manometric and histologic results, 15 of whom were positive for HD and 30 negative. In five children, the results were discordant. Using histologic aganglionosis as the reference point for the final diagnosis of HD, the overall accuracy of anorectal manometry as a discriminative test was 90.0%. The sensitivity, specificity, and positive and negative predictive values of manometric studies for the diagnosis of HD were 0.79, 0.97, 0.94, and 0.88, respectively. Factors responsible for the inaccuracies of manometric studies are discussed. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/2614621/Accuracy_of_anorectal_manometry_in_the_diagnosis_of_Hirschsprung's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2614621.ui DB - PRIME DP - Unbound Medicine ER -