Abstract
BACKGROUND
The sebaceous gland and the follicular bulge region have important role in biology of the hair. They initiate destruction of the hair follicle both in human and animal models in certain conditions. The morphometric feature of the sebaceous gland is not well understood so as the distribution of the bulge stem cells in pathological conditions of male pattern hair loss or androgenic alopecia (AGA).
OBJECTIVES
The authors perform morphometric analysis of the sebaceous gland in AGA patients and also study distribution of the follicular stem cells in the bulge region in these populations.
METHODS
Two hundred and fifty cases of glass slide specimen from Japanese patients with male pattern hair loss were reviewed. Among these, 23 cases of the longitudinal (vertical) sections of the scalp skin with diagnosis of AGA were found and analyzed for the morphometric characteristics. Each sebaceous gland area was measured using NIH imagej system and statistically analyzed. For the identification of the follicular bulge region, an immunohistochemistry using anticytokeratin 15 (C8/144B clone) was carried out in the cases of AGA.
RESULTS
The sebaceous gland area of the AGA group was noticeably increased, while the size of each sebaceous gland remains unchanged. It has more lobules in the hair follicular unit in the AGA population. In the immunohistochemistry, the follicular stem cells are present in the bulge regions in cases of AGA.
CONCLUSIONS
The overgrowth (multilobulation) of the sebaceous gland and relative preservation of the follicular stem cells suggest that the changes in the sebaceous gland could be an important factor in the pathology of AGA.
TY - JOUR
T1 - Changes in the sebaceous gland in patients with male pattern hair loss (androgenic alopecia).
AU - Kure,Katsuhiro,
AU - Isago,Tsukasa,
AU - Hirayama,Takeshi,
Y1 - 2015/07/03/
PY - 2015/04/09/accepted
PY - 2015/7/7/entrez
PY - 2015/7/7/pubmed
PY - 2016/6/9/medline
KW - androgenic alopecia
KW - follicular stem cell
KW - immunohistochemistry
KW - male pattern hair loss
KW - sebaceous gland
SP - 178
EP - 84
JF - Journal of cosmetic dermatology
JO - J Cosmet Dermatol
VL - 14
IS - 3
N2 - BACKGROUND: The sebaceous gland and the follicular bulge region have important role in biology of the hair. They initiate destruction of the hair follicle both in human and animal models in certain conditions. The morphometric feature of the sebaceous gland is not well understood so as the distribution of the bulge stem cells in pathological conditions of male pattern hair loss or androgenic alopecia (AGA). OBJECTIVES: The authors perform morphometric analysis of the sebaceous gland in AGA patients and also study distribution of the follicular stem cells in the bulge region in these populations. METHODS: Two hundred and fifty cases of glass slide specimen from Japanese patients with male pattern hair loss were reviewed. Among these, 23 cases of the longitudinal (vertical) sections of the scalp skin with diagnosis of AGA were found and analyzed for the morphometric characteristics. Each sebaceous gland area was measured using NIH imagej system and statistically analyzed. For the identification of the follicular bulge region, an immunohistochemistry using anticytokeratin 15 (C8/144B clone) was carried out in the cases of AGA. RESULTS: The sebaceous gland area of the AGA group was noticeably increased, while the size of each sebaceous gland remains unchanged. It has more lobules in the hair follicular unit in the AGA population. In the immunohistochemistry, the follicular stem cells are present in the bulge regions in cases of AGA. CONCLUSIONS: The overgrowth (multilobulation) of the sebaceous gland and relative preservation of the follicular stem cells suggest that the changes in the sebaceous gland could be an important factor in the pathology of AGA.
SN - 1473-2165
UR - https://www.unboundmedicine.com/medline/citation/26147300/Changes_in_the_sebaceous_gland_in_patients_with_male_pattern_hair_loss__androgenic_alopecia__
DB - PRIME
DP - Unbound Medicine
ER -
