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Fish, n - 3 polyunsaturated fatty acids and n - 6 polyunsaturated fatty acids intake and breast cancer risk: The Japan Public Health Center-based prospective study.
Int J Cancer 2015; 137(12):2915-26IJ

Abstract

Limited and inconsistent studies exist on the association between the intake of fish, n - 3 polyunsaturated fatty acids (PUFA) and n - 6 PUFA and breast cancer. Fish and n - 3 PUFA support various body functions and are thought to reduce the carcinogenesis risk while n - 6 PUFA may have a positive association with cancer risk. We examined the association between intake of fish, n - 3 PUFA [including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA)] and n - 6 PUFA and breast cancer with subanalyses on estrogen (ER) and progesterone receptor (PR) status. We investigated 38,234 Japanese women aged 45-74 years from the Japan Public Health Center-based prospective study (JPHC study), and during 14.1 years of follow-up time, 556 breast cancer cases were newly diagnosed. Breast cancer risk was not associated with the intake of total fish, n - 3 PUFA and n - 6 PUFA when analyzed in totality through multivariable Cox proportional hazards regression models with age as the time scale. Intake of total n - 6 was positively associated with the development of ER+PR+ tumors [multivariable-adjusted HR Q4 vs. Q1 = 2.94 (95% CI: 1.26-6.89; ptrend = 0.02)]. Intake of EPA was associated with a decreased breast cancer risk for ER+PR+ tumors [multivariable-adjusted HR Q2 vs. Q1 = 0.47 (95% CI: 0.25-0.89; ptrend =0.47)]. While the overall association between the intake of total fish, n - 3 PUFA and n - 6 PUFA and breast cancer risk is null, for ER+PR+ tumors, a positive association was seen between n - 6 intake and breast cancer, and a marginally significant inverse association was observed for EPA intake.

Authors+Show Affiliations

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.AXA Department of Health and Human Security, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.AXA Department of Health and Human Security, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.AXA Department of Health and Human Security, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.Department of Nutrition Management, Sagami Women's University, Kanagawa Prefecture, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26147326

Citation

Kiyabu, Grace Y., et al. "Fish, N - 3 Polyunsaturated Fatty Acids and N - 6 Polyunsaturated Fatty Acids Intake and Breast Cancer Risk: the Japan Public Health Center-based Prospective Study." International Journal of Cancer, vol. 137, no. 12, 2015, pp. 2915-26.
Kiyabu GY, Inoue M, Saito E, et al. Fish, n - 3 polyunsaturated fatty acids and n - 6 polyunsaturated fatty acids intake and breast cancer risk: The Japan Public Health Center-based prospective study. Int J Cancer. 2015;137(12):2915-26.
Kiyabu, G. Y., Inoue, M., Saito, E., Abe, S. K., Sawada, N., Ishihara, J., ... Tsugane, S. (2015). Fish, n - 3 polyunsaturated fatty acids and n - 6 polyunsaturated fatty acids intake and breast cancer risk: The Japan Public Health Center-based prospective study. International Journal of Cancer, 137(12), pp. 2915-26. doi:10.1002/ijc.29672.
Kiyabu GY, et al. Fish, N - 3 Polyunsaturated Fatty Acids and N - 6 Polyunsaturated Fatty Acids Intake and Breast Cancer Risk: the Japan Public Health Center-based Prospective Study. Int J Cancer. 2015 Dec 15;137(12):2915-26. PubMed PMID: 26147326.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish, n - 3 polyunsaturated fatty acids and n - 6 polyunsaturated fatty acids intake and breast cancer risk: The Japan Public Health Center-based prospective study. AU - Kiyabu,Grace Y, AU - Inoue,Manami, AU - Saito,Eiko, AU - Abe,Sarah K, AU - Sawada,Norie, AU - Ishihara,Junko, AU - Iwasaki,Motoki, AU - Yamaji,Taiki, AU - Shimazu,Taichi, AU - Sasazuki,Shizuka, AU - Shibuya,Kenji, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2015/07/28/ PY - 2015/04/02/received PY - 2015/06/25/accepted PY - 2015/7/7/entrez PY - 2015/7/7/pubmed PY - 2016/1/26/medline KW - breast cancer KW - diet KW - fatty acids KW - fish KW - receptor SP - 2915 EP - 26 JF - International journal of cancer JO - Int. J. Cancer VL - 137 IS - 12 N2 - Limited and inconsistent studies exist on the association between the intake of fish, n - 3 polyunsaturated fatty acids (PUFA) and n - 6 PUFA and breast cancer. Fish and n - 3 PUFA support various body functions and are thought to reduce the carcinogenesis risk while n - 6 PUFA may have a positive association with cancer risk. We examined the association between intake of fish, n - 3 PUFA [including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA)] and n - 6 PUFA and breast cancer with subanalyses on estrogen (ER) and progesterone receptor (PR) status. We investigated 38,234 Japanese women aged 45-74 years from the Japan Public Health Center-based prospective study (JPHC study), and during 14.1 years of follow-up time, 556 breast cancer cases were newly diagnosed. Breast cancer risk was not associated with the intake of total fish, n - 3 PUFA and n - 6 PUFA when analyzed in totality through multivariable Cox proportional hazards regression models with age as the time scale. Intake of total n - 6 was positively associated with the development of ER+PR+ tumors [multivariable-adjusted HR Q4 vs. Q1 = 2.94 (95% CI: 1.26-6.89; ptrend = 0.02)]. Intake of EPA was associated with a decreased breast cancer risk for ER+PR+ tumors [multivariable-adjusted HR Q2 vs. Q1 = 0.47 (95% CI: 0.25-0.89; ptrend =0.47)]. While the overall association between the intake of total fish, n - 3 PUFA and n - 6 PUFA and breast cancer risk is null, for ER+PR+ tumors, a positive association was seen between n - 6 intake and breast cancer, and a marginally significant inverse association was observed for EPA intake. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26147326/Fish_n___3_polyunsaturated_fatty_acids_and_n___6_polyunsaturated_fatty_acids_intake_and_breast_cancer_risk:_The_Japan_Public_Health_Center_based_prospective_study_ L2 - https://doi.org/10.1002/ijc.29672 DB - PRIME DP - Unbound Medicine ER -