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Chronic fatigue syndrome and circulating cytokines: A systematic review.
Brain Behav Immun. 2015 Nov; 50:186-195.BB

Abstract

There has been much interest in the role of the immune system in the pathophysiology of chronic fatigue syndrome (CFS), as CFS may develop following an infection and cytokines are known to induce acute sickness behaviour, with similar symptoms to CFS. Using the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a search was conducted on PubMed, Web of Science, Embase and PsycINFO, for CFS related-terms in combination with cytokine-related terms. Cases had to meet established criteria for CFS and be compared with healthy controls. Papers retrieved were assessed for both inclusionary criteria and quality. 38 papers met the inclusionary criteria. The quality of the studies varied. 77 serum or plasma cytokines were measured without immune stimulation. Cases of CFS had significantly elevated concentrations of transforming growth factor-beta (TGF-β) in five out of eight (63%) studies. No other cytokines were present in abnormal concentrations in the majority of studies, although insufficient data were available for some cytokines. Following physical exercise there were no differences in circulating cytokine levels between cases and controls and exercise made no difference to already elevated TGF-β concentrations. The finding of elevated TGF-β concentration, at biologically relevant levels, needs further exploration, but circulating cytokines do not seem to explain the core characteristic of post-exertional fatigue.

Authors+Show Affiliations

Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom.East London Foundation NHS Trust, London, United Kingdom.Barts Health Trust, London, United Kingdom.Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom. Electronic address: p.d.white@qmul.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26148446

Citation

Blundell, S, et al. "Chronic Fatigue Syndrome and Circulating Cytokines: a Systematic Review." Brain, Behavior, and Immunity, vol. 50, 2015, pp. 186-195.
Blundell S, Ray KK, Buckland M, et al. Chronic fatigue syndrome and circulating cytokines: A systematic review. Brain Behav Immun. 2015;50:186-195.
Blundell, S., Ray, K. K., Buckland, M., & White, P. D. (2015). Chronic fatigue syndrome and circulating cytokines: A systematic review. Brain, Behavior, and Immunity, 50, 186-195. https://doi.org/10.1016/j.bbi.2015.07.004
Blundell S, et al. Chronic Fatigue Syndrome and Circulating Cytokines: a Systematic Review. Brain Behav Immun. 2015;50:186-195. PubMed PMID: 26148446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic fatigue syndrome and circulating cytokines: A systematic review. AU - Blundell,S, AU - Ray,K K, AU - Buckland,M, AU - White,P D, Y1 - 2015/07/03/ PY - 2015/03/13/received PY - 2015/06/11/revised PY - 2015/07/02/accepted PY - 2015/7/8/entrez PY - 2015/7/8/pubmed PY - 2016/8/16/medline KW - Chemokine KW - Chronic fatigue syndrome KW - Cytokine KW - Immune system KW - Myalgic encephalomyelitis KW - Pathophysiology KW - Systematic review KW - Transforming growth factor-beta SP - 186 EP - 195 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 50 N2 - There has been much interest in the role of the immune system in the pathophysiology of chronic fatigue syndrome (CFS), as CFS may develop following an infection and cytokines are known to induce acute sickness behaviour, with similar symptoms to CFS. Using the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a search was conducted on PubMed, Web of Science, Embase and PsycINFO, for CFS related-terms in combination with cytokine-related terms. Cases had to meet established criteria for CFS and be compared with healthy controls. Papers retrieved were assessed for both inclusionary criteria and quality. 38 papers met the inclusionary criteria. The quality of the studies varied. 77 serum or plasma cytokines were measured without immune stimulation. Cases of CFS had significantly elevated concentrations of transforming growth factor-beta (TGF-β) in five out of eight (63%) studies. No other cytokines were present in abnormal concentrations in the majority of studies, although insufficient data were available for some cytokines. Following physical exercise there were no differences in circulating cytokine levels between cases and controls and exercise made no difference to already elevated TGF-β concentrations. The finding of elevated TGF-β concentration, at biologically relevant levels, needs further exploration, but circulating cytokines do not seem to explain the core characteristic of post-exertional fatigue. SN - 1090-2139 UR - https://www.unboundmedicine.com/medline/citation/26148446/Chronic_fatigue_syndrome_and_circulating_cytokines:_A_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(15)00238-X DB - PRIME DP - Unbound Medicine ER -