Abstract
Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various therapeutic approaches are being used to improve the cholinergic neurotransmission, but their role in AD pathogenesis is still unknown. Although, an increase in tau protein concentration in CSF has been described in AD, but several issues remains unclear. Extensive and accurate analysis of CSF could be helpful to define presence of tau proteins in physiological conditions, or released during the progression of neurodegenerative disease. The amyloid cascade hypothesis postulates that the neurodegeneration in AD caused by abnormal accumulation of amyloid beta (Aβ) plaques in various areas of the brain. The amyloid hypothesis has continued to gain support over the last two decades, particularly from genetic studies. Therefore, current research progress in several areas of therapies shall provide an effective treatment to cure this devastating disease. This review critically evaluates general biochemical and physiological functions of Aβ directed therapeutics and their relevance.
TY - JOUR
T1 - Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease.
AU - Barage,Sagar H,
AU - Sonawane,Kailas D,
Y1 - 2015/07/02/
PY - 2014/09/10/received
PY - 2015/06/24/revised
PY - 2015/06/24/accepted
PY - 2015/7/8/entrez
PY - 2015/7/8/pubmed
PY - 2016/5/11/medline
KW - AD genetics
KW - Alzheimer's disease
KW - Amyloid based therapies
KW - Amyloid cascade hypothesis
KW - Aβ degrading enzyme
KW - Neuropeptides
SP - 1
EP - 18
JF - Neuropeptides
JO - Neuropeptides
VL - 52
N2 - Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various therapeutic approaches are being used to improve the cholinergic neurotransmission, but their role in AD pathogenesis is still unknown. Although, an increase in tau protein concentration in CSF has been described in AD, but several issues remains unclear. Extensive and accurate analysis of CSF could be helpful to define presence of tau proteins in physiological conditions, or released during the progression of neurodegenerative disease. The amyloid cascade hypothesis postulates that the neurodegeneration in AD caused by abnormal accumulation of amyloid beta (Aβ) plaques in various areas of the brain. The amyloid hypothesis has continued to gain support over the last two decades, particularly from genetic studies. Therefore, current research progress in several areas of therapies shall provide an effective treatment to cure this devastating disease. This review critically evaluates general biochemical and physiological functions of Aβ directed therapeutics and their relevance.
SN - 1532-2785
UR - https://www.unboundmedicine.com/medline/citation/26149638/Amyloid_cascade_hypothesis:_Pathogenesis_and_therapeutic_strategies_in_Alzheimer's_disease_
DB - PRIME
DP - Unbound Medicine
ER -
