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Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study.
BMC Nephrol. 2015 Jul 07; 16:96.BN

Abstract

BACKGROUND

Chronic kidney disease (CKD) is a major threat to the health of people of African ancestry. We assessed the prevalence and risk factors of CKD among adults in urban Cameroon.

METHODS

This was a cross-sectional study of two months duration (March to April 2013) conducted at the Cité des Palmiers health district in the Littoral region of Cameroon. A multistage cluster sampling approach was applied. Estimated glomerular filtration rate (eGFR) was based on the Cockcroft-Gault (CG), the four-variable Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Logistic regression models were used to investigate the predictors of CKD.

RESULTS

In the 500 participants with a mean age of 45.3 ± 13.2 years included, we observed a high prevalence of overweight and obesity (60.4 %), hypertension (38.6 %) and diabetes (2.8 %). The mean eGFR was 93.7 ± 24.9, 97.8 ± 24.9 and 99.2 ± 31.4 ml/min respectively with the MDRD, CG and CKD-EPI equations. The prevalence of albuminuria was 7.2 % while the prevalence of decreased GFR (eGFR < 60 ml/min) and CKD (any albuminuria and/or eGFR < 60 ml/min) was 4.4 and 11 % with MDRD, 5.4 and 14.2 % with CG, and 8.8 and 10 % with CKD-EPI. In age and sex adjusted logistic regression models, advanced age, known hypertension and diabetes mellitus, increasing body mass index and overweight/obesity were the predictors of albuminuria, decreased GFR and CKD according to various estimators.

CONCLUSION

There is a high prevalence of CKD in urban adults Cameroonian, driven essentially by the commonest risk factors for CKD.

Authors+Show Affiliations

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University Teaching Hospital of Yaoundé, University of Yaoundé 1, Yaoundé, Cameroon. francoiskaze@yahoo.fr.Department of Internal Medicine, Faculty of Medicine and Pharmaceutical Sciences, Douala General Hospital, University of Douala, Douala, Cameroon. patricehalle@yahoo.fr.Higher Institute of Health Sciences, Bangangté, Cameroon. mopahermine@yahoo.fr.Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé General Hospital, University of Yaoundé 1, Yaoundé, Cameroon. maglo09@hotmail.com.Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, Douala General Hospital, University of Yaoundé 1, Yaoundé, Cameroon. mendjouf@yahoo.fr.Department of Biochemistry and Physiologic Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon. jngogang@yahoo.fr.South African Medical Research Council, University of Cape Town, Cape Town, South Africa. apkengne@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26149764

Citation

Kaze, Francois Folefack, et al. "Prevalence and Risk Factors of Chronic Kidney Disease in Urban Adult Cameroonians According to Three Common Estimators of the Glomerular Filtration Rate: a Cross-sectional Study." BMC Nephrology, vol. 16, 2015, p. 96.
Kaze FF, Halle MP, Mopa HT, et al. Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. BMC Nephrol. 2015;16:96.
Kaze, F. F., Halle, M. P., Mopa, H. T., Ashuntantang, G., Fouda, H., Ngogang, J., & Kengne, A. P. (2015). Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. BMC Nephrology, 16, 96. https://doi.org/10.1186/s12882-015-0102-9
Kaze FF, et al. Prevalence and Risk Factors of Chronic Kidney Disease in Urban Adult Cameroonians According to Three Common Estimators of the Glomerular Filtration Rate: a Cross-sectional Study. BMC Nephrol. 2015 Jul 7;16:96. PubMed PMID: 26149764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and risk factors of chronic kidney disease in urban adult Cameroonians according to three common estimators of the glomerular filtration rate: a cross-sectional study. AU - Kaze,Francois Folefack, AU - Halle,Marie-Patrice, AU - Mopa,Hermine Tchuendem, AU - Ashuntantang,Gloria, AU - Fouda,Hermine, AU - Ngogang,Jeanne, AU - Kengne,Andre-Pascal, Y1 - 2015/07/07/ PY - 2014/12/14/received PY - 2015/06/28/accepted PY - 2015/7/8/entrez PY - 2015/7/8/pubmed PY - 2016/3/16/medline SP - 96 EP - 96 JF - BMC nephrology JO - BMC Nephrol VL - 16 N2 - BACKGROUND: Chronic kidney disease (CKD) is a major threat to the health of people of African ancestry. We assessed the prevalence and risk factors of CKD among adults in urban Cameroon. METHODS: This was a cross-sectional study of two months duration (March to April 2013) conducted at the Cité des Palmiers health district in the Littoral region of Cameroon. A multistage cluster sampling approach was applied. Estimated glomerular filtration rate (eGFR) was based on the Cockcroft-Gault (CG), the four-variable Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Logistic regression models were used to investigate the predictors of CKD. RESULTS: In the 500 participants with a mean age of 45.3 ± 13.2 years included, we observed a high prevalence of overweight and obesity (60.4 %), hypertension (38.6 %) and diabetes (2.8 %). The mean eGFR was 93.7 ± 24.9, 97.8 ± 24.9 and 99.2 ± 31.4 ml/min respectively with the MDRD, CG and CKD-EPI equations. The prevalence of albuminuria was 7.2 % while the prevalence of decreased GFR (eGFR < 60 ml/min) and CKD (any albuminuria and/or eGFR < 60 ml/min) was 4.4 and 11 % with MDRD, 5.4 and 14.2 % with CG, and 8.8 and 10 % with CKD-EPI. In age and sex adjusted logistic regression models, advanced age, known hypertension and diabetes mellitus, increasing body mass index and overweight/obesity were the predictors of albuminuria, decreased GFR and CKD according to various estimators. CONCLUSION: There is a high prevalence of CKD in urban adults Cameroonian, driven essentially by the commonest risk factors for CKD. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/26149764/Prevalence_and_risk_factors_of_chronic_kidney_disease_in_urban_adult_Cameroonians_according_to_three_common_estimators_of_the_glomerular_filtration_rate:_a_cross_sectional_study_ L2 - https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0102-9 DB - PRIME DP - Unbound Medicine ER -