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Anticancer Effect of Lycopene in Gastric Carcinogenesis.

Abstract

Gastric cancer ranks as the most common cancer and the second leading cause of cancer-related death in the world. Risk factors of gastric carcinogenesis include oxidative stress, DNA damage, Helicobacter pylori infection, bad eating habits, and smoking. Since oxidative stress is related to DNA damage, smoking, and H. pylori infection, scavenging of reactive oxygen species may be beneficial for prevention of gastric carcinogenesis. Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity. It shows a potential anticancer activity and reduces gastric cancer incidence. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

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  • Authors+Show Affiliations

    ,

    Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

    Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.

    Source

    Journal of cancer prevention 20:2 2015 Jun pg 92-6

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26151041

    Citation

    Kim, Mi Jung, and Hyeyoung Kim. "Anticancer Effect of Lycopene in Gastric Carcinogenesis." Journal of Cancer Prevention, vol. 20, no. 2, 2015, pp. 92-6.
    Kim MJ, Kim H. Anticancer Effect of Lycopene in Gastric Carcinogenesis. J Cancer Prev. 2015;20(2):92-6.
    Kim, M. J., & Kim, H. (2015). Anticancer Effect of Lycopene in Gastric Carcinogenesis. Journal of Cancer Prevention, 20(2), pp. 92-6. doi:10.15430/JCP.2015.20.2.92.
    Kim MJ, Kim H. Anticancer Effect of Lycopene in Gastric Carcinogenesis. J Cancer Prev. 2015;20(2):92-6. PubMed PMID: 26151041.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anticancer Effect of Lycopene in Gastric Carcinogenesis. AU - Kim,Mi Jung, AU - Kim,Hyeyoung, PY - 2015/05/18/received PY - 2015/06/20/revised PY - 2015/06/20/accepted PY - 2015/7/8/entrez PY - 2015/7/8/pubmed PY - 2015/7/8/medline KW - Anticancer effect KW - Gastric carcinogenesis KW - Lycopene SP - 92 EP - 6 JF - Journal of cancer prevention JO - J Cancer Prev VL - 20 IS - 2 N2 - Gastric cancer ranks as the most common cancer and the second leading cause of cancer-related death in the world. Risk factors of gastric carcinogenesis include oxidative stress, DNA damage, Helicobacter pylori infection, bad eating habits, and smoking. Since oxidative stress is related to DNA damage, smoking, and H. pylori infection, scavenging of reactive oxygen species may be beneficial for prevention of gastric carcinogenesis. Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity. It shows a potential anticancer activity and reduces gastric cancer incidence. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies. SN - 2288-3649 UR - https://www.unboundmedicine.com/medline/citation/26151041/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26151041/ DB - PRIME DP - Unbound Medicine ER -