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Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project.
Br J Dermatol 2015; 173(5):1175-82BJ

Abstract

BACKGROUND

There is a well-known association between atopic dermatitis (AD) and hand eczema but less is known about how age at onset, persistence and severity of AD influence the risk of developing hand eczema.

OBJECTIVES

To examine the role of AD in the occurrence of hand eczema in adolescence. In addition, associations between asthma and rhinoconjunctivitis, sensitization to common airborne and food allergens, and hand eczema were studied.

METHODS

From the population-based birth cohort BAMSE, 2927 adolescents who had been followed up repeatedly concerning allergy-related disease were included. Questionnaires identified adolescents with hand eczema at 16 years, and their blood was analysed for specific IgE.

RESULTS

A total of 152 (5·2%) adolescents had hand eczema at the age of 16 years. Many of these adolescents had a history of AD (n = 111; 73·0%) and asthma and/or rhinitis (n = 83; 54·6%), respectively. Children with AD (aged 0-16 years) had more than threefold increased odds ratios (OR) for having hand eczema; those with persistent or severe AD had a crude OR of 6·1 [95% confidence interval (CI) 4·0-9·1] and 5·3 (95% CI 2·9-9·6), respectively.

CONCLUSIONS

We confirm a strong association between AD during childhood and hand eczema in adolescence. Children with persistent or more severe AD are at greater risk of developing hand eczema. Asthma and/or rhinoconjunctivitis, positive specific IgE or age at onset of AD are not associated with hand eczema in adolescence.

Authors+Show Affiliations

Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.Karolinska Institutet and Karolinska University Hospital, Dermatology Unit, Department of Medicine, Stockholm, Sweden.Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden. South General Hospital, Sachs' Children and Youth Hospital, Stockholm, Sweden.Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden. South General Hospital, Sachs' Children and Youth Hospital, Stockholm, Sweden. South General Hospital, Department of Clinical Science and Education, Stockholm, Sweden.Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26152456

Citation

Grönhagen, C, et al. "Hand Eczema and Atopic Dermatitis in Adolescents: a Prospective Cohort Study From the BAMSE Project." The British Journal of Dermatology, vol. 173, no. 5, 2015, pp. 1175-82.
Grönhagen C, Lidén C, Wahlgren CF, et al. Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project. Br J Dermatol. 2015;173(5):1175-82.
Grönhagen, C., Lidén, C., Wahlgren, C. F., Ballardini, N., Bergström, A., Kull, I., & Meding, B. (2015). Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project. The British Journal of Dermatology, 173(5), pp. 1175-82. doi:10.1111/bjd.14019.
Grönhagen C, et al. Hand Eczema and Atopic Dermatitis in Adolescents: a Prospective Cohort Study From the BAMSE Project. Br J Dermatol. 2015;173(5):1175-82. PubMed PMID: 26152456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hand eczema and atopic dermatitis in adolescents: a prospective cohort study from the BAMSE project. AU - Grönhagen,C, AU - Lidén,C, AU - Wahlgren,C-F, AU - Ballardini,N, AU - Bergström,A, AU - Kull,I, AU - Meding,B, Y1 - 2015/10/21/ PY - 2015/06/29/accepted PY - 2015/7/9/entrez PY - 2015/7/15/pubmed PY - 2016/10/19/medline SP - 1175 EP - 82 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 173 IS - 5 N2 - BACKGROUND: There is a well-known association between atopic dermatitis (AD) and hand eczema but less is known about how age at onset, persistence and severity of AD influence the risk of developing hand eczema. OBJECTIVES: To examine the role of AD in the occurrence of hand eczema in adolescence. In addition, associations between asthma and rhinoconjunctivitis, sensitization to common airborne and food allergens, and hand eczema were studied. METHODS: From the population-based birth cohort BAMSE, 2927 adolescents who had been followed up repeatedly concerning allergy-related disease were included. Questionnaires identified adolescents with hand eczema at 16 years, and their blood was analysed for specific IgE. RESULTS: A total of 152 (5·2%) adolescents had hand eczema at the age of 16 years. Many of these adolescents had a history of AD (n = 111; 73·0%) and asthma and/or rhinitis (n = 83; 54·6%), respectively. Children with AD (aged 0-16 years) had more than threefold increased odds ratios (OR) for having hand eczema; those with persistent or severe AD had a crude OR of 6·1 [95% confidence interval (CI) 4·0-9·1] and 5·3 (95% CI 2·9-9·6), respectively. CONCLUSIONS: We confirm a strong association between AD during childhood and hand eczema in adolescence. Children with persistent or more severe AD are at greater risk of developing hand eczema. Asthma and/or rhinoconjunctivitis, positive specific IgE or age at onset of AD are not associated with hand eczema in adolescence. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/26152456/Hand_eczema_and_atopic_dermatitis_in_adolescents:_a_prospective_cohort_study_from_the_BAMSE_project_ L2 - https://doi.org/10.1111/bjd.14019 DB - PRIME DP - Unbound Medicine ER -