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Simultaneous identification of amphetamine and methamphetamine using solid-phase extraction and gas chromatography/nitrogen phosphorous detection or gas chromatography/mass spectrometry.
J Anal Toxicol. 1989 Sep-Oct; 13(5):293-5.JA

Abstract

A method for the simultaneous detection and quantitation of amphetamine and methamphetamine in urine is described. Using solid-phase extraction, amphetamine, methamphetamine, and n-propylamphetamine (internal standard) are extracted from urine samples. Drugs in their free form are identified using gas chromatography/nitrogen-phosphorous detection (GC/NPD), whereas their heptafluorobutyric anhydride derivatives are detected by gas chromatography/mass spectrometry (GC/MS) in the selected ion monitoring (SIM) mode. Limits of detection for both amphetamine and methamphetamine are approximately 35 ng/mL. The procedure is simple, rapid, and suitable for a large number of specimens (25 or more).

Authors+Show Affiliations

Los Angeles County Sheriff's Department, Scientific Services Bureau, California 90057-2494.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2615339

Citation

Taylor, R W., et al. "Simultaneous Identification of Amphetamine and Methamphetamine Using Solid-phase Extraction and Gas Chromatography/nitrogen Phosphorous Detection or Gas Chromatography/mass Spectrometry." Journal of Analytical Toxicology, vol. 13, no. 5, 1989, pp. 293-5.
Taylor RW, Le SD, Philip S, et al. Simultaneous identification of amphetamine and methamphetamine using solid-phase extraction and gas chromatography/nitrogen phosphorous detection or gas chromatography/mass spectrometry. J Anal Toxicol. 1989;13(5):293-5.
Taylor, R. W., Le, S. D., Philip, S., & Jain, N. C. (1989). Simultaneous identification of amphetamine and methamphetamine using solid-phase extraction and gas chromatography/nitrogen phosphorous detection or gas chromatography/mass spectrometry. Journal of Analytical Toxicology, 13(5), 293-5.
Taylor RW, et al. Simultaneous Identification of Amphetamine and Methamphetamine Using Solid-phase Extraction and Gas Chromatography/nitrogen Phosphorous Detection or Gas Chromatography/mass Spectrometry. J Anal Toxicol. 1989 Sep-Oct;13(5):293-5. PubMed PMID: 2615339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous identification of amphetamine and methamphetamine using solid-phase extraction and gas chromatography/nitrogen phosphorous detection or gas chromatography/mass spectrometry. AU - Taylor,R W, AU - Le,S D, AU - Philip,S, AU - Jain,N C, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 293 EP - 5 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 13 IS - 5 N2 - A method for the simultaneous detection and quantitation of amphetamine and methamphetamine in urine is described. Using solid-phase extraction, amphetamine, methamphetamine, and n-propylamphetamine (internal standard) are extracted from urine samples. Drugs in their free form are identified using gas chromatography/nitrogen-phosphorous detection (GC/NPD), whereas their heptafluorobutyric anhydride derivatives are detected by gas chromatography/mass spectrometry (GC/MS) in the selected ion monitoring (SIM) mode. Limits of detection for both amphetamine and methamphetamine are approximately 35 ng/mL. The procedure is simple, rapid, and suitable for a large number of specimens (25 or more). SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/2615339/Simultaneous_identification_of_amphetamine_and_methamphetamine_using_solid_phase_extraction_and_gas_chromatography/nitrogen_phosphorous_detection_or_gas_chromatography/mass_spectrometry_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/13.5.293 DB - PRIME DP - Unbound Medicine ER -