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Clinical outcomes of primary surgical treatment for acquired vulvar lymphangioma circumscriptum.
Arch Gynecol Obstet. 2016 Jan; 293(1):157-162.AG

Abstract

OBJECTIVE

To assess the clinical outcomes of surgical treatment for acquired vulvar lymphangioma circumscriptum in patients who received radical surgery and/or adjuvant radiation therapy for cervical cancer.

METHODS

A retrospective chart review of eight patients was performed to assess the demographic information, chief complaints, treatment modality for cervical cancer, location, and primary treatment modality for vulvar LC, postoperative changes in symptoms, and/or signs, the development of local recurrence and the outcome of patients.

RESULTS

All eight patients were previously diagnosed with cervical cancer FIGO clinical stage IA to IIA and received surgery, radiation therapy, or concurrent chemoradiation therapy. Microscopic examination revealed multiple, dilated, D2-40-positive dermal vascular channels containing eosinophilic proteinaceous material, consistent with LC. Most chief complaints showed considerable improvements on assessment at the outpatient clinic after the primary surgery. No patient showed aggravation of symptoms. Two patients developed local recurrences. One patient developed recurrence on the opposite side 13 months after local excision. We performed a second wide local excision. Another patient developed recurrence 47 months after the primary surgery. Since the lesion was very small and localized, we decided to manage it conservatively, but monitor it very closely. The remaining six patients remained free of recurrence.

CONCLUSION

It is not easy for gynecologists to have an initial clinical diagnosis of LC, because there are a number of diseases that exhibit similar clinical manifestation to that of vulvar LC. Even if it is diagnosed correctly, local recurrence often occurs. Relevant symptoms associated with LC are not only distressing, but also affect patients' quality of life. Based on our data, we propose that surgical treatment could provide a more long-lasting answer compared to other treatment modalities, since it is beneficial in terms of clinical outcomes. In the future, a long-term follow-up investigation is required to assess the prognosis and to compare the efficacy and side effects of each modality.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea. jhlee.hwang@samsung.com.Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea. garden.lee@samsung.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26156111

Citation

Yoon, Gun, et al. "Clinical Outcomes of Primary Surgical Treatment for Acquired Vulvar Lymphangioma Circumscriptum." Archives of Gynecology and Obstetrics, vol. 293, no. 1, 2016, pp. 157-162.
Yoon G, Kim HS, Lee YY, et al. Clinical outcomes of primary surgical treatment for acquired vulvar lymphangioma circumscriptum. Arch Gynecol Obstet. 2016;293(1):157-162.
Yoon, G., Kim, H. S., Lee, Y. Y., Kim, T. J., Choi, C. H., Kim, B. G., Bae, D. S., Hwang, J. H., & Lee, J. W. (2016). Clinical outcomes of primary surgical treatment for acquired vulvar lymphangioma circumscriptum. Archives of Gynecology and Obstetrics, 293(1), 157-162. https://doi.org/10.1007/s00404-015-3801-3
Yoon G, et al. Clinical Outcomes of Primary Surgical Treatment for Acquired Vulvar Lymphangioma Circumscriptum. Arch Gynecol Obstet. 2016;293(1):157-162. PubMed PMID: 26156111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical outcomes of primary surgical treatment for acquired vulvar lymphangioma circumscriptum. AU - Yoon,Gun, AU - Kim,Hyun-Soo, AU - Lee,Yoo-Young, AU - Kim,Tae-Joong, AU - Choi,Chel-Hun, AU - Kim,Byoung-Gie, AU - Bae,Duk-Soo, AU - Hwang,Ji Hye, AU - Lee,Jeong-Won, Y1 - 2015/07/09/ PY - 2015/03/12/received PY - 2015/06/17/accepted PY - 2015/7/10/entrez PY - 2015/7/15/pubmed PY - 2016/7/16/medline KW - Cervical cancer KW - Lymphangioma circumscriptum KW - Radiation therapy KW - Radical hysterectomy KW - Surgery KW - Vulva SP - 157 EP - 162 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 293 IS - 1 N2 - OBJECTIVE: To assess the clinical outcomes of surgical treatment for acquired vulvar lymphangioma circumscriptum in patients who received radical surgery and/or adjuvant radiation therapy for cervical cancer. METHODS: A retrospective chart review of eight patients was performed to assess the demographic information, chief complaints, treatment modality for cervical cancer, location, and primary treatment modality for vulvar LC, postoperative changes in symptoms, and/or signs, the development of local recurrence and the outcome of patients. RESULTS: All eight patients were previously diagnosed with cervical cancer FIGO clinical stage IA to IIA and received surgery, radiation therapy, or concurrent chemoradiation therapy. Microscopic examination revealed multiple, dilated, D2-40-positive dermal vascular channels containing eosinophilic proteinaceous material, consistent with LC. Most chief complaints showed considerable improvements on assessment at the outpatient clinic after the primary surgery. No patient showed aggravation of symptoms. Two patients developed local recurrences. One patient developed recurrence on the opposite side 13 months after local excision. We performed a second wide local excision. Another patient developed recurrence 47 months after the primary surgery. Since the lesion was very small and localized, we decided to manage it conservatively, but monitor it very closely. The remaining six patients remained free of recurrence. CONCLUSION: It is not easy for gynecologists to have an initial clinical diagnosis of LC, because there are a number of diseases that exhibit similar clinical manifestation to that of vulvar LC. Even if it is diagnosed correctly, local recurrence often occurs. Relevant symptoms associated with LC are not only distressing, but also affect patients' quality of life. Based on our data, we propose that surgical treatment could provide a more long-lasting answer compared to other treatment modalities, since it is beneficial in terms of clinical outcomes. In the future, a long-term follow-up investigation is required to assess the prognosis and to compare the efficacy and side effects of each modality. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/26156111/Clinical_outcomes_of_primary_surgical_treatment_for_acquired_vulvar_lymphangioma_circumscriptum_ L2 - https://dx.doi.org/10.1007/s00404-015-3801-3 DB - PRIME DP - Unbound Medicine ER -