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Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: The Possible Immune Privilege of Ectopic Endometrium.
Reprod Sci. 2016 Jan; 23(1):81-6.RS

Abstract

The Fas/Fas-Ligand system is an important mediator of apoptosis. We analyzed their expression in tissue specimens obtained from 33 women with severe endometriosis and 18 women without endometriosis. Immunostaining for Fas-Ligand in the eutopic endometrium was stronger in the epithelial cells of secretory phase, while the epithelial cells of endometriotic lesions showed a significantly stronger staining for Fas-Ligand independently from the menstrual phase (P < 0.01). Immunostaining for Fas in the eutopic endometrium showed a reduced staining during the proliferative phase, whereas it was strong in the secretory phase. The epithelial cells of the ectopic endometrium showed a reduced staining for Fas independently from the menstrual phase with respect to the eutopic tissue (P < 0.01). The reduced expression of Fas in the ectopic endometrium with the contemporary higher expression of Fas-Ligand in the corresponding cells suggests a possible immune privilege of this tissue.

Authors+Show Affiliations

Department of Urologic and Gynaecologic Science, University of Tor Vergata, Rome, Italy.Praxi Provita, Praxis DS, Rome, Italy claudia.valeri84@gmail.com.Department of Urologic and Gynaecologic Science, University of Sapienza, Rome, Italy.Praxi Provita, Praxis DS, Rome, Italy.Praxi Provita, Praxis DS, Rome, Italy Department of Urologic and Gynaecologic Science, University of Sapienza, Rome, Italy.Praxi Provita, Praxis DS, Rome, Italy Department of Urologic and Gynaecologic Science, University of Sapienza, Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26156853

Citation

Sbracia, Marco, et al. "Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: the Possible Immune Privilege of Ectopic Endometrium." Reproductive Sciences (Thousand Oaks, Calif.), vol. 23, no. 1, 2016, pp. 81-6.
Sbracia M, Valeri C, Antonini G, et al. Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: The Possible Immune Privilege of Ectopic Endometrium. Reprod Sci. 2016;23(1):81-6.
Sbracia, M., Valeri, C., Antonini, G., Biagiotti, G., Pacchiarotti, A., & Pacchiarotti, A. (2016). Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: The Possible Immune Privilege of Ectopic Endometrium. Reproductive Sciences (Thousand Oaks, Calif.), 23(1), 81-6. https://doi.org/10.1177/1933719115594019
Sbracia M, et al. Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: the Possible Immune Privilege of Ectopic Endometrium. Reprod Sci. 2016;23(1):81-6. PubMed PMID: 26156853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fas and Fas-Ligand in Eutopic and Ectopic Endometrium of Women With Endometriosis: The Possible Immune Privilege of Ectopic Endometrium. AU - Sbracia,Marco, AU - Valeri,Claudia, AU - Antonini,Gabriele, AU - Biagiotti,Giulio, AU - Pacchiarotti,Alessandro, AU - Pacchiarotti,Arianna, Y1 - 2015/07/07/ PY - 2015/7/10/entrez PY - 2015/7/15/pubmed PY - 2017/1/19/medline KW - Fas KW - Fas ligand KW - ectopic endometrium KW - endometriosis KW - eutopic endometrium SP - 81 EP - 6 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 23 IS - 1 N2 - The Fas/Fas-Ligand system is an important mediator of apoptosis. We analyzed their expression in tissue specimens obtained from 33 women with severe endometriosis and 18 women without endometriosis. Immunostaining for Fas-Ligand in the eutopic endometrium was stronger in the epithelial cells of secretory phase, while the epithelial cells of endometriotic lesions showed a significantly stronger staining for Fas-Ligand independently from the menstrual phase (P < 0.01). Immunostaining for Fas in the eutopic endometrium showed a reduced staining during the proliferative phase, whereas it was strong in the secretory phase. The epithelial cells of the ectopic endometrium showed a reduced staining for Fas independently from the menstrual phase with respect to the eutopic tissue (P < 0.01). The reduced expression of Fas in the ectopic endometrium with the contemporary higher expression of Fas-Ligand in the corresponding cells suggests a possible immune privilege of this tissue. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/26156853/Fas_and_Fas_Ligand_in_Eutopic_and_Ectopic_Endometrium_of_Women_With_Endometriosis:_The_Possible_Immune_Privilege_of_Ectopic_Endometrium_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719115594019?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -