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Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors.
Hormones (Athens). 2015 Apr-Jun; 14(2):251-7.H

Abstract

OBJECTIVE

The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension).

DESIGN

Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS.

RESULTS

Levels of TNF-α, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively).

CONCLUSION

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major CV risk factors.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Barcellos CR
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
Rocha MP
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
Hayashida SA
Gynecology Unit, University of Sao Paulo, School of Medicine, Brazil.
Dantas WS
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
Dos Reis Vieira Yance V
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.
Marcondes JA
Endocrinlogy Unit, University of Sao Paulo, School of Medicine, Brazil.

MeSH

AdolescentAdultBiomarkersBody Mass IndexC-Reactive ProteinFemaleHumansInflammationInsulin ResistanceInterleukin-6ObesityPolycystic Ovary SyndromeTumor Necrosis Factor-alphaYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26158655

Citation

Barcellos, Cristiano Roberto, et al. "Obesity, but Not Polycystic Ovary Syndrome, Affects Circulating Markers of Low-grade Inflammation in Young Women Without Major Cardiovascular Risk Factors." Hormones (Athens, Greece), vol. 14, no. 2, 2015, pp. 251-7.
Barcellos CR, Rocha MP, Hayashida SA, et al. Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors. Hormones (Athens). 2015;14(2):251-7.
Barcellos, C. R., Rocha, M. P., Hayashida, S. A., Dantas, W. S., Dos Reis Vieira Yance, V., & Marcondes, J. A. (2015). Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors. Hormones (Athens, Greece), 14(2), 251-7. https://doi.org/10.14310/horm.2002.1584
Barcellos CR, et al. Obesity, but Not Polycystic Ovary Syndrome, Affects Circulating Markers of Low-grade Inflammation in Young Women Without Major Cardiovascular Risk Factors. Hormones (Athens). 2015 Apr-Jun;14(2):251-7. PubMed PMID: 26158655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors. AU - Barcellos,Cristiano Roberto, AU - Rocha,Michelle Patrocínio, AU - Hayashida,Sylvia Asaka, AU - Dantas,Wagner Silva, AU - Dos Reis Vieira Yance,Viviane, AU - Marcondes,José Antonio, PY - 2015/7/10/entrez PY - 2015/7/15/pubmed PY - 2016/4/7/medline SP - 251 EP - 7 JF - Hormones (Athens, Greece) JO - Hormones (Athens) VL - 14 IS - 2 N2 - OBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension). DESIGN: Twenty-five young women with PCOS and 23 eumenorrheic women without major CV risk factors and matched for body mass index (BMI) were studied. They were subdivided according to BMI and PCOS status and comparisons were made between the PCOS and Control groups, regardless of BMI, and between the Obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-α, IL-6 and hsCRP were similar between the PCOS group and the Control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hsCRP were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). CONCLUSION: Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major CV risk factors. SN - 2520-8721 UR - https://www.unboundmedicine.com/medline/citation/26158655/Obesity_but_not_polycystic_ovary_syndrome_affects_circulating_markers_of_low_grade_inflammation_in_young_women_without_major_cardiovascular_risk_factors_ DB - PRIME DP - Unbound Medicine ER -