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Mediterranean Diet and Risk of Dementia.

Abstract

Dementia is a major global health challenge, as its burden on society will increase with population aging. Given the lack of effective pharmaceutical treatment for common types of dementia including Alzheimer's disease and vascular dementia, research interest in lifestyle modifications that could prevent, postpone the clinical syndrome or decelerate progression of dementia is growing. Among the various dietary patterns that were tested for their effects on cognition, the traditional Mediterranean diet (MeDi) has shown promising results. This review aims to summarize the epidemiological evidence on the effects of MeDi on the prevention of dementia, presenting data from cross-sectional as well as longitudinal observational studies conducted both in Mediterranean and non-Mediterranean countries. These findings have been also reproduced in the context of one recent randomized-controlled clinical trial. Postulated mechanisms of action that may account for the potential protective effect of MeDi on cognitive impairment will be briefly discussed. Despite the fact that the link between MeDi and cognitive decline has been only explored for less than a decade, data on efficacy is rapidly increasing and allows optimism that MeDi could emerge as an alternative prophylactic treatment for dementia.

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  • Authors+Show Affiliations

    , , ,

    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Greece, 75, M. Asias Str., Athens 115 27, Greece. tpsaltop@med.uoa.gr.

    Source

    Current Alzheimer research 12:8 2015 pg 736-44

    MeSH

    Cognition Disorders
    Dementia
    Diet, Mediterranean
    Humans
    Life Style
    Randomized Controlled Trials as Topic
    Risk

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26159192

    Citation

    Safouris, Apostolos, et al. "Mediterranean Diet and Risk of Dementia." Current Alzheimer Research, vol. 12, no. 8, 2015, pp. 736-44.
    Safouris A, Tsivgoulis G, Sergentanis TN, et al. Mediterranean Diet and Risk of Dementia. Curr Alzheimer Res. 2015;12(8):736-44.
    Safouris, A., Tsivgoulis, G., Sergentanis, T. N., & Psaltopoulou, T. (2015). Mediterranean Diet and Risk of Dementia. Current Alzheimer Research, 12(8), pp. 736-44.
    Safouris A, et al. Mediterranean Diet and Risk of Dementia. Curr Alzheimer Res. 2015;12(8):736-44. PubMed PMID: 26159192.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Mediterranean Diet and Risk of Dementia. AU - Safouris,Apostolos, AU - Tsivgoulis,Georgios, AU - Sergentanis,Theodoros N, AU - Psaltopoulou,Theodora, PY - 2015/01/24/received PY - 2015/07/03/accepted PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/7/2/medline SP - 736 EP - 44 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 12 IS - 8 N2 - Dementia is a major global health challenge, as its burden on society will increase with population aging. Given the lack of effective pharmaceutical treatment for common types of dementia including Alzheimer's disease and vascular dementia, research interest in lifestyle modifications that could prevent, postpone the clinical syndrome or decelerate progression of dementia is growing. Among the various dietary patterns that were tested for their effects on cognition, the traditional Mediterranean diet (MeDi) has shown promising results. This review aims to summarize the epidemiological evidence on the effects of MeDi on the prevention of dementia, presenting data from cross-sectional as well as longitudinal observational studies conducted both in Mediterranean and non-Mediterranean countries. These findings have been also reproduced in the context of one recent randomized-controlled clinical trial. Postulated mechanisms of action that may account for the potential protective effect of MeDi on cognitive impairment will be briefly discussed. Despite the fact that the link between MeDi and cognitive decline has been only explored for less than a decade, data on efficacy is rapidly increasing and allows optimism that MeDi could emerge as an alternative prophylactic treatment for dementia. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/26159192/Mediterranean_Diet_and_Risk_of_Dementia_ L2 - http://www.eurekaselect.com/132992/article DB - PRIME DP - Unbound Medicine ER -