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Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) on the Immune Response to the Pandemic Strain H1N1.

Abstract

BACKGROUND

Annual vaccination of children against seasonal influenza with trivalent inactivated influenza vaccine (TIV) has shown to be beneficial. However, this yearly practice may have unintended effect. Studies have shown that infection with wild type influenza A viruses can stimulate protective heterotypic immunity against unrelated or new influenza subtypes. We hypothesized that a consequence of yearly TIV vaccination is lack of induction of heterotypic immunity against the recent H1N1 pandemic.

METHODS

This was a retrospective case-control study. We reviewed the medical records of polymerase chain reaction-confirmed cases of 2009 H1N1 influenza infection in children 6 months to 18 years and a matched control group seen during the pandemic.

RESULTS

We identified 353 polymerase chain reaction-confirmed H1N1 cases and 396 matching control subjects. Among the H1N1 group, 202/353 (57%) cases received a total of 477 doses of seasonal TIV compared with 218/396 (55%) in the control group who received a total of 435 doses. Seasonal TIV uptake was significantly higher in the H1N1 group 477/548 (87%) than in the control group, 435/532 (81%) (P = .017).

CONCLUSION

Seasonal TIV uptake was significantly higher in H1N1-infected group. The finding suggests that the practice of yearly vaccination with TIV might have negatively affected the immune response against the novel pandemic H1N1 strain. Given the rarity of pandemic novel influenza viruses, and the high predictability of seasonal influenza occurrence, the practice of yearly influenza vaccination should be continued. However, the use of live attenuated intranasal vaccine, as opposed to TIV, may allow for the desirable development of a vigorous heterotypic immune response against future pandemics.

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  • Authors+Show Affiliations

    ,

    Wayne State University School of Medicine, Detroit, MI, USA Children's Hospital of Michigan, Detroit, MI, USA aamer@med.wayne.edu.

    ,

    Wayne State University School of Medicine, Detroit, MI, USA Children's Hospital of Michigan, Detroit, MI, USA.

    ,

    Wayne State University School of Medicine, Detroit, MI, USA.

    Wayne State University School of Medicine, Detroit, MI, USA Children's Hospital of Michigan, Detroit, MI, USA.

    Source

    Clinical pediatrics 55:3 2016 Mar pg 245-50

    MeSH

    Adolescent
    Case-Control Studies
    Child
    Child, Preschool
    Female
    Humans
    Immunization Schedule
    Infant
    Influenza A Virus, H1N1 Subtype
    Influenza Vaccines
    Influenza, Human
    Male
    Pandemics
    Retrospective Studies
    Vaccination
    Vaccines, Inactivated

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26159622

    Citation

    Amer, Ahdi, et al. "Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) On the Immune Response to the Pandemic Strain H1N1." Clinical Pediatrics, vol. 55, no. 3, 2016, pp. 245-50.
    Amer A, Fischer H, Li X, et al. Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) on the Immune Response to the Pandemic Strain H1N1. Clin Pediatr (Phila). 2016;55(3):245-50.
    Amer, A., Fischer, H., Li, X., & Asmar, B. (2016). Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) on the Immune Response to the Pandemic Strain H1N1. Clinical Pediatrics, 55(3), pp. 245-50. doi:10.1177/0009922815594357.
    Amer A, et al. Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) On the Immune Response to the Pandemic Strain H1N1. Clin Pediatr (Phila). 2016;55(3):245-50. PubMed PMID: 26159622.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Possible Impact of Yearly Childhood Vaccination With Trivalent Inactivated Influenza Vaccine (TIV) on the Immune Response to the Pandemic Strain H1N1. AU - Amer,Ahdi, AU - Fischer,Howard, AU - Li,Xiaoming, AU - Asmar,Basim, Y1 - 2015/07/09/ PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/6/21/medline KW - H1N1 pandemic strain KW - heterotypic immunity KW - live attenuated intranasal vaccine KW - seasonal influenza KW - trivalent inactivated influenza vaccine SP - 245 EP - 50 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 55 IS - 3 N2 - BACKGROUND: Annual vaccination of children against seasonal influenza with trivalent inactivated influenza vaccine (TIV) has shown to be beneficial. However, this yearly practice may have unintended effect. Studies have shown that infection with wild type influenza A viruses can stimulate protective heterotypic immunity against unrelated or new influenza subtypes. We hypothesized that a consequence of yearly TIV vaccination is lack of induction of heterotypic immunity against the recent H1N1 pandemic. METHODS: This was a retrospective case-control study. We reviewed the medical records of polymerase chain reaction-confirmed cases of 2009 H1N1 influenza infection in children 6 months to 18 years and a matched control group seen during the pandemic. RESULTS: We identified 353 polymerase chain reaction-confirmed H1N1 cases and 396 matching control subjects. Among the H1N1 group, 202/353 (57%) cases received a total of 477 doses of seasonal TIV compared with 218/396 (55%) in the control group who received a total of 435 doses. Seasonal TIV uptake was significantly higher in the H1N1 group 477/548 (87%) than in the control group, 435/532 (81%) (P = .017). CONCLUSION: Seasonal TIV uptake was significantly higher in H1N1-infected group. The finding suggests that the practice of yearly vaccination with TIV might have negatively affected the immune response against the novel pandemic H1N1 strain. Given the rarity of pandemic novel influenza viruses, and the high predictability of seasonal influenza occurrence, the practice of yearly influenza vaccination should be continued. However, the use of live attenuated intranasal vaccine, as opposed to TIV, may allow for the desirable development of a vigorous heterotypic immune response against future pandemics. SN - 1938-2707 UR - https://www.unboundmedicine.com/medline/citation/26159622/Possible_Impact_of_Yearly_Childhood_Vaccination_With_Trivalent_Inactivated_Influenza_Vaccine__TIV__on_the_Immune_Response_to_the_Pandemic_Strain_H1N1_ L2 - http://journals.sagepub.com/doi/full/10.1177/0009922815594357?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -