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Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men.
J Appl Physiol (1985). 2015 Sep 01; 119(5):475-86.JA

Abstract

The study was a randomized placebo-controlled trial investigating mechanisms by which chronic β2-adrenergic stimulation enhances muscle force and power output during maximal cycle ergometer exercise in young men. Eighteen trained men were assigned to an experimental group [oral terbutaline 5 mg/30 kg body weight (bw) twice daily (TER); n = 9] or a control group [placebo (PLA); n = 9] for a 4-wk intervention. No changes were observed with the intervention in PLA. Isometric muscle force of the quadriceps increased (P ≤ 0.01) by 97 ± 29 N (means ± SE) with the intervention in TER compared with PLA. Peak and mean power output during 30 s of maximal cycling increased (P ≤ 0.01) by 32 ± 8 and 25 ± 9 W, respectively, with the intervention in TER compared with PLA. Maximal oxygen consumption (V̇o2max) and time to fatigue during incremental cycling did not change with the intervention. Lean body mass increased by 1.95 ± 0.8 kg (P ≤ 0.05) with the intervention in TER compared with PLA. Change in single fiber cross-sectional area of myosin heavy chain (MHC) I (1,205 ± 558 μm(2); P ≤ 0.01) and MHC II fibers (1,277 ± 595 μm(2); P ≤ 0.05) of the vastus lateralis muscle was higher for TER than PLA with the intervention, whereas no changes were observed in MHC isoform distribution. Expression of muscle proteins involved in growth, ion handling, lactate production, and clearance increased (P ≤ 0.05) with the intervention in TER compared with PLA, with no change in oxidative enzymes. Our observations suggest that muscle hypertrophy is the primary mechanism underlying enhancements in muscle force and peak power during maximal cycling induced by chronic β2-adrenergic stimulation in humans.

Authors+Show Affiliations

Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark; Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark;Department of Sports Science and Biomechanics, University of Southern Denmark, Odense, Denmark; and Swedish Winter Sports Research Centre, Mid Sweden University, Sundsvall, Sweden.Department of Respiratory Research, Bispebjerg University Hospital, Copenhagen, Denmark;Department of Nutrition, Exercise and Sports, Section of Integrated Physiology, University of Copenhagen, Copenhagen, Denmark; jbangsbo@nexs.ku.dk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26159759

Citation

Hostrup, Morten, et al. "Mechanisms Underlying Enhancements in Muscle Force and Power Output During Maximal Cycle Ergometer Exercise Induced By Chronic Β2-adrenergic Stimulation in Men." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 119, no. 5, 2015, pp. 475-86.
Hostrup M, Kalsen A, Onslev J, et al. Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. J Appl Physiol. 2015;119(5):475-86.
Hostrup, M., Kalsen, A., Onslev, J., Jessen, S., Haase, C., Habib, S., Ørtenblad, N., Backer, V., & Bangsbo, J. (2015). Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. Journal of Applied Physiology (Bethesda, Md. : 1985), 119(5), 475-86. https://doi.org/10.1152/japplphysiol.00319.2015
Hostrup M, et al. Mechanisms Underlying Enhancements in Muscle Force and Power Output During Maximal Cycle Ergometer Exercise Induced By Chronic Β2-adrenergic Stimulation in Men. J Appl Physiol. 2015 Sep 1;119(5):475-86. PubMed PMID: 26159759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. AU - Hostrup,Morten, AU - Kalsen,Anders, AU - Onslev,Johan, AU - Jessen,Søren, AU - Haase,Christoffer, AU - Habib,Sajad, AU - Ørtenblad,Niels, AU - Backer,Vibeke, AU - Bangsbo,Jens, Y1 - 2015/07/09/ PY - 2015/04/17/received PY - 2015/07/07/accepted PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/6/4/medline KW - Ca2+ handling KW - beta-adrenoceptor KW - contractile properties KW - doping KW - muscle growth SP - 475 EP - 86 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 119 IS - 5 N2 - The study was a randomized placebo-controlled trial investigating mechanisms by which chronic β2-adrenergic stimulation enhances muscle force and power output during maximal cycle ergometer exercise in young men. Eighteen trained men were assigned to an experimental group [oral terbutaline 5 mg/30 kg body weight (bw) twice daily (TER); n = 9] or a control group [placebo (PLA); n = 9] for a 4-wk intervention. No changes were observed with the intervention in PLA. Isometric muscle force of the quadriceps increased (P ≤ 0.01) by 97 ± 29 N (means ± SE) with the intervention in TER compared with PLA. Peak and mean power output during 30 s of maximal cycling increased (P ≤ 0.01) by 32 ± 8 and 25 ± 9 W, respectively, with the intervention in TER compared with PLA. Maximal oxygen consumption (V̇o2max) and time to fatigue during incremental cycling did not change with the intervention. Lean body mass increased by 1.95 ± 0.8 kg (P ≤ 0.05) with the intervention in TER compared with PLA. Change in single fiber cross-sectional area of myosin heavy chain (MHC) I (1,205 ± 558 μm(2); P ≤ 0.01) and MHC II fibers (1,277 ± 595 μm(2); P ≤ 0.05) of the vastus lateralis muscle was higher for TER than PLA with the intervention, whereas no changes were observed in MHC isoform distribution. Expression of muscle proteins involved in growth, ion handling, lactate production, and clearance increased (P ≤ 0.05) with the intervention in TER compared with PLA, with no change in oxidative enzymes. Our observations suggest that muscle hypertrophy is the primary mechanism underlying enhancements in muscle force and peak power during maximal cycling induced by chronic β2-adrenergic stimulation in humans. SN - 1522-1601 UR - https://www.unboundmedicine.com/medline/citation/26159759/Mechanisms_underlying_enhancements_in_muscle_force_and_power_output_during_maximal_cycle_ergometer_exercise_induced_by_chronic_β2_adrenergic_stimulation_in_men_ L2 - http://www.physiology.org/doi/full/10.1152/japplphysiol.00319.2015?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -