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The levels of trace elements and heavy metals in patients with acute migraine headache.
J Pak Med Assoc 2015; 65(7):694-7JP

Abstract

OBJECTIVE

To compare the levels of trace elements and heavy metal in patients with acute migraine and healthy controls.

METHODS

The prospective study was conducted at Yuzuncu Yil University, Turkey, from May to July 2013, and comprised migraine patients and an equal number of healthy controls. International Headache Society classification was used for diagnosing migraine. Serum copper, zinc, lead, iron, cadmium, cobalt, manganese, and magnesium levels were measured in both groups. Metal concentrations were assessed by atomic absorption spectrophotometry. SPSS 13 was used for statistical analysis.

RESULTS

There were 25 migraine patients with an average age of 36.4±8.9 years and 25 healthy controls with a mean age of 42.4±9.5 years. Cadmium, iron, manganese and lead levels were significantly elevated in the patients compared to the controls (p<0.05 each), while copper, magnesium and zinc were decreased and cobalt demonstrated no change.

CONCLUSIONS

Trace elements and heavy metals may have a role in the genesis of considerable oxidative stress in patients with acute migraine headache.

Authors+Show Affiliations

Department of Emergency Medicine, Yuzuncu Yil University, School of Medicine, Van, Turkey.Anesteshiology, Van Region Training and Research Hospital, Van, Turkey.Department of Emergency Medicine, Yuzuncu Yil University, School of Medicine, Van, Turkey.Department of Neurosurgery, Yuzuncu Yil University, School of Medicine, Van, Turkey.Department of Neurosurgery, Dokuz Eylul University, School of Medicine, Izmir Turkey.Neurosurgery, Van Region Training and Research Hospital, Van, Turkey.Department of Neurology, Yuzuncu Yil University, School of Medicine, Van, Turkey.Department of Chemistry, Yuzuncu Yil University, School of Medicine, Van, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26160074

Citation

Gonullu, Hayriye, et al. "The Levels of Trace Elements and Heavy Metals in Patients With Acute Migraine Headache." JPMA. the Journal of the Pakistan Medical Association, vol. 65, no. 7, 2015, pp. 694-7.
Gonullu H, Gonullu E, Karadas S, et al. The levels of trace elements and heavy metals in patients with acute migraine headache. J Pak Med Assoc. 2015;65(7):694-7.
Gonullu, H., Gonullu, E., Karadas, S., Arslan, M., Kalemci, O., Aycan, A., ... Demir, H. (2015). The levels of trace elements and heavy metals in patients with acute migraine headache. JPMA. the Journal of the Pakistan Medical Association, 65(7), pp. 694-7.
Gonullu H, et al. The Levels of Trace Elements and Heavy Metals in Patients With Acute Migraine Headache. J Pak Med Assoc. 2015;65(7):694-7. PubMed PMID: 26160074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The levels of trace elements and heavy metals in patients with acute migraine headache. AU - Gonullu,Hayriye, AU - Gonullu,Edip, AU - Karadas,Sevdegul, AU - Arslan,Mehmet, AU - Kalemci,Orhan, AU - Aycan,Abdurrahman, AU - Sayin,Refah, AU - Demir,Halit, PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2015/12/30/medline KW - Acute migraine attack, Trace elements, Heavy metals. SP - 694 EP - 7 JF - JPMA. The Journal of the Pakistan Medical Association JO - J Pak Med Assoc VL - 65 IS - 7 N2 - OBJECTIVE: To compare the levels of trace elements and heavy metal in patients with acute migraine and healthy controls. METHODS: The prospective study was conducted at Yuzuncu Yil University, Turkey, from May to July 2013, and comprised migraine patients and an equal number of healthy controls. International Headache Society classification was used for diagnosing migraine. Serum copper, zinc, lead, iron, cadmium, cobalt, manganese, and magnesium levels were measured in both groups. Metal concentrations were assessed by atomic absorption spectrophotometry. SPSS 13 was used for statistical analysis. RESULTS: There were 25 migraine patients with an average age of 36.4±8.9 years and 25 healthy controls with a mean age of 42.4±9.5 years. Cadmium, iron, manganese and lead levels were significantly elevated in the patients compared to the controls (p<0.05 each), while copper, magnesium and zinc were decreased and cobalt demonstrated no change. CONCLUSIONS: Trace elements and heavy metals may have a role in the genesis of considerable oxidative stress in patients with acute migraine headache. SN - 0030-9982 UR - https://www.unboundmedicine.com/medline/citation/26160074/The_levels_of_trace_elements_and_heavy_metals_in_patients_with_acute_migraine_headache_ L2 - http://jpma.org.pk/full_article-text.php?article_id=7394 DB - PRIME DP - Unbound Medicine ER -