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Exogenous and endogenous determinants of vitamin K status in cystic fibrosis.
Sci Rep 2015; 5:12000SR

Abstract

Cystic fibrosis (CF) patients are at high risk for vitamin K deficiency. The effects of vitamin K supplementation are very ambiguous. Therefore, we aimed to define the determinants of vitamin K deficiency in a large cohort of supplemented - 146 (86.9%) and non-supplemented - 22 (13.1%) CF patients. Vitamin K status was assessed using prothrombin inducted by vitamin K absence (PIVKA-II) and undercarboxylated osteocalcin (u-OC). The pathological PIVKA-II concentration (≥ 2 ng/ml) and abnormal percentage of osteocalcin (≥ 20%) were found in 72 (42.8%) and 60 (35.7%) subjects, respectively. We found that liver involvement, diabetes, and glucocorticoid therapy were potential risk factors for vitamin K deficiency. Pathological concentrations of PIVKA-II occurred more frequently in patients with pancreatic insufficiency and those who have two severe mutations in both alleles of the CFTR gene. Pathological percentage of u-OC was found more frequently in adult CF patients and those not receiving vitamin K. However, it seems that there are no good predictive factors of vitamin K deficiency in CF patients in everyday clinical care. Early vitamin K supplementation in CF patients seems to be warranted. It is impossible to clearly determine the supplementation dose. Therefore, constant monitoring of vitamin K status seems to be justified.

Authors+Show Affiliations

Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.Department of Pneumology and Cystic Fibrosis, Institute of Tuberculosis and Lung Diseases, Rabka, Poland.National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland.Department of Informatics and Statistics, Poznan University of Medical Sciences, Poznan, Poland.Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26160248

Citation

Krzyżanowska, Patrycja, et al. "Exogenous and Endogenous Determinants of Vitamin K Status in Cystic Fibrosis." Scientific Reports, vol. 5, 2015, p. 12000.
Krzyżanowska P, Pogorzelski A, Skorupa W, et al. Exogenous and endogenous determinants of vitamin K status in cystic fibrosis. Sci Rep. 2015;5:12000.
Krzyżanowska, P., Pogorzelski, A., Skorupa, W., Moczko, J., Grebowiec, P., & Walkowiak, J. (2015). Exogenous and endogenous determinants of vitamin K status in cystic fibrosis. Scientific Reports, 5, p. 12000. doi:10.1038/srep12000.
Krzyżanowska P, et al. Exogenous and Endogenous Determinants of Vitamin K Status in Cystic Fibrosis. Sci Rep. 2015 Jul 10;5:12000. PubMed PMID: 26160248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exogenous and endogenous determinants of vitamin K status in cystic fibrosis. AU - Krzyżanowska,Patrycja, AU - Pogorzelski,Andrzej, AU - Skorupa,Wojciech, AU - Moczko,Jerzy, AU - Grebowiec,Philip, AU - Walkowiak,Jarosław, Y1 - 2015/07/10/ PY - 2015/01/09/received PY - 2015/05/13/accepted PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/8/2/medline SP - 12000 EP - 12000 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Cystic fibrosis (CF) patients are at high risk for vitamin K deficiency. The effects of vitamin K supplementation are very ambiguous. Therefore, we aimed to define the determinants of vitamin K deficiency in a large cohort of supplemented - 146 (86.9%) and non-supplemented - 22 (13.1%) CF patients. Vitamin K status was assessed using prothrombin inducted by vitamin K absence (PIVKA-II) and undercarboxylated osteocalcin (u-OC). The pathological PIVKA-II concentration (≥ 2 ng/ml) and abnormal percentage of osteocalcin (≥ 20%) were found in 72 (42.8%) and 60 (35.7%) subjects, respectively. We found that liver involvement, diabetes, and glucocorticoid therapy were potential risk factors for vitamin K deficiency. Pathological concentrations of PIVKA-II occurred more frequently in patients with pancreatic insufficiency and those who have two severe mutations in both alleles of the CFTR gene. Pathological percentage of u-OC was found more frequently in adult CF patients and those not receiving vitamin K. However, it seems that there are no good predictive factors of vitamin K deficiency in CF patients in everyday clinical care. Early vitamin K supplementation in CF patients seems to be warranted. It is impossible to clearly determine the supplementation dose. Therefore, constant monitoring of vitamin K status seems to be justified. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26160248/Exogenous_and_endogenous_determinants_of_vitamin_K_status_in_cystic_fibrosis_ L2 - http://dx.doi.org/10.1038/srep12000 DB - PRIME DP - Unbound Medicine ER -