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A crossover study comparing gabapentin and fluoxetine for the treatment of vasomotor symptoms among postmenopausal women.
Int J Gynaecol Obstet. 2015 Oct; 131(1):87-90.IJ

Abstract

OBJECTIVE

To compare the effectiveness of fluoxetine and gabapentin for treatment of vasomotor symptoms (VMS) after the menopause.

METHODS

Between March 2011 and March 2012, a randomized crossover study was performed at a center in Semnan, Iran, among postmenopausal women aged 45-57 years with hot flashes (≥2 per day for previous 4 months) for which they had received no previous treatment. Participants were divided into two groups with consecutive numbers assigned in order of recruitment. In the first treatment round (4 weeks), group A received 20mg/day fluoxetine and group B received 300 mg/day gabapentin. After a 2-week washout period, group A received gabapentin and group B received fluoxetine in a second round (4 weeks). Information about VMS was obtained with the Greene Climacteric Scale questionnaire. Participants and all investigators except one were masked to group assignment.

RESULTS

Data for 79 participants (39 in group A, 40 in group B) were analyzed. In both treatment rounds, gabapentin caused greater reductions in the severity of hot flashes than did fluoxetine (P<0.001 for both). After the first round of treatment, those who had received gabapentin reported greater reductions in the severity of night sweats (P<0.001).

CONCLUSION

Gabapentin at a dose of 300 mg/day is more effective for treatment of VMS among postmenopausal women than is 20 mg/day fluoxetine. Iranian Registry of Clinical Trials:IRCT2014092711019N3.

Authors+Show Affiliations

Research Center of Abnormal Uterine Bleeding, Semnan University of Medical Sciences, Semnan, Iran.Research Center of Abnormal Uterine Bleeding, Semnan University of Medical Sciences, Semnan, Iran.Research Center for Social Determinants of Health, Department of Community Medicine, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: r_ghorbani@semums.ac.ir.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26160608

Citation

Rahmanian, Mojgan, et al. "A Crossover Study Comparing Gabapentin and Fluoxetine for the Treatment of Vasomotor Symptoms Among Postmenopausal Women." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 131, no. 1, 2015, pp. 87-90.
Rahmanian M, Mohseni A, Ghorbani R. A crossover study comparing gabapentin and fluoxetine for the treatment of vasomotor symptoms among postmenopausal women. Int J Gynaecol Obstet. 2015;131(1):87-90.
Rahmanian, M., Mohseni, A., & Ghorbani, R. (2015). A crossover study comparing gabapentin and fluoxetine for the treatment of vasomotor symptoms among postmenopausal women. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 131(1), 87-90. https://doi.org/10.1016/j.ijgo.2015.04.042
Rahmanian M, Mohseni A, Ghorbani R. A Crossover Study Comparing Gabapentin and Fluoxetine for the Treatment of Vasomotor Symptoms Among Postmenopausal Women. Int J Gynaecol Obstet. 2015;131(1):87-90. PubMed PMID: 26160608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A crossover study comparing gabapentin and fluoxetine for the treatment of vasomotor symptoms among postmenopausal women. AU - Rahmanian,Mojgan, AU - Mohseni,Arash, AU - Ghorbani,Raheb, Y1 - 2015/06/30/ PY - 2014/11/29/received PY - 2015/03/31/revised PY - 2015/06/18/accepted PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/7/12/medline KW - Fluoxetine KW - Gabapentin KW - Hot flash KW - Night sweats KW - Vasomotor symptoms SP - 87 EP - 90 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 131 IS - 1 N2 - OBJECTIVE: To compare the effectiveness of fluoxetine and gabapentin for treatment of vasomotor symptoms (VMS) after the menopause. METHODS: Between March 2011 and March 2012, a randomized crossover study was performed at a center in Semnan, Iran, among postmenopausal women aged 45-57 years with hot flashes (≥2 per day for previous 4 months) for which they had received no previous treatment. Participants were divided into two groups with consecutive numbers assigned in order of recruitment. In the first treatment round (4 weeks), group A received 20mg/day fluoxetine and group B received 300 mg/day gabapentin. After a 2-week washout period, group A received gabapentin and group B received fluoxetine in a second round (4 weeks). Information about VMS was obtained with the Greene Climacteric Scale questionnaire. Participants and all investigators except one were masked to group assignment. RESULTS: Data for 79 participants (39 in group A, 40 in group B) were analyzed. In both treatment rounds, gabapentin caused greater reductions in the severity of hot flashes than did fluoxetine (P<0.001 for both). After the first round of treatment, those who had received gabapentin reported greater reductions in the severity of night sweats (P<0.001). CONCLUSION: Gabapentin at a dose of 300 mg/day is more effective for treatment of VMS among postmenopausal women than is 20 mg/day fluoxetine. Iranian Registry of Clinical Trials:IRCT2014092711019N3. SN - 1879-3479 UR - https://www.unboundmedicine.com/medline/citation/26160608/A_crossover_study_comparing_gabapentin_and_fluoxetine_for_the_treatment_of_vasomotor_symptoms_among_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-7292(15)00404-X DB - PRIME DP - Unbound Medicine ER -