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Fish Oil and Osteoarthritis: Current Evidence.

Abstract

According to the 2005 US census, osteoarthritis (OA) was the leading cause of disability in the United States, affecting more than 50 million people. Current treatments are targeted at reducing symptoms of the inflammatory reaction that occurs after destruction of essential joint cartilage. However, these treatments do not prevent significant pain and activity restriction. We reviewed the literature to address claims that fish oil supplementation can prevent or decrease severity of OA. Our extensive search of databases covered all relevant terms related to omega-3-containing supplements and their effects on OA. We hypothesized there would be insufficient clinical studies to justify recommending supplementation to patients.Laboratory studies have shown that eicosapentaenoic acid and docosahexaenoic acid reduce proinflammatory mediators and increase joint lubrication in vitro. In addition, canine trials have shown clinically significant reductions in various symptom parameters. Results of human clinical trials have not been consistently significant. Well-designed clinical trials are needed to substantiate or refute the potential benefit of fish oils in OA treatment. Long-term studies are needed to assess the possibility of prevention. In addition, standardization of the fish oil industry is needed for consistency of therapy.

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  • Authors+Show Affiliations

    ,

    Mayo School of Graduate Medical Education, Rochester, MN. boe.chelsea@mayo.edu.

    Source

    MeSH

    Animals
    Cartilage, Articular
    Dietary Supplements
    Docosahexaenoic Acids
    Dogs
    Eicosapentaenoic Acid
    Evidence-Based Medicine
    Fish Oils
    Humans
    Osteoarthritis

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26161757

    Citation

    Boe, Chelsea, and C Thomas Vangsness. "Fish Oil and Osteoarthritis: Current Evidence." American Journal of Orthopedics (Belle Mead, N.J.), vol. 44, no. 7, 2015, pp. 302-5.
    Boe C, Vangsness CT. Fish Oil and Osteoarthritis: Current Evidence. Am J Orthop. 2015;44(7):302-5.
    Boe, C., & Vangsness, C. T. (2015). Fish Oil and Osteoarthritis: Current Evidence. American Journal of Orthopedics (Belle Mead, N.J.), 44(7), pp. 302-5.
    Boe C, Vangsness CT. Fish Oil and Osteoarthritis: Current Evidence. Am J Orthop. 2015;44(7):302-5. PubMed PMID: 26161757.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fish Oil and Osteoarthritis: Current Evidence. AU - Boe,Chelsea, AU - Vangsness,C Thomas, PY - 2015/7/11/entrez PY - 2015/7/15/pubmed PY - 2016/4/12/medline SP - 302 EP - 5 JF - American journal of orthopedics (Belle Mead, N.J.) JO - Am J. Orthop. VL - 44 IS - 7 N2 - According to the 2005 US census, osteoarthritis (OA) was the leading cause of disability in the United States, affecting more than 50 million people. Current treatments are targeted at reducing symptoms of the inflammatory reaction that occurs after destruction of essential joint cartilage. However, these treatments do not prevent significant pain and activity restriction. We reviewed the literature to address claims that fish oil supplementation can prevent or decrease severity of OA. Our extensive search of databases covered all relevant terms related to omega-3-containing supplements and their effects on OA. We hypothesized there would be insufficient clinical studies to justify recommending supplementation to patients.Laboratory studies have shown that eicosapentaenoic acid and docosahexaenoic acid reduce proinflammatory mediators and increase joint lubrication in vitro. In addition, canine trials have shown clinically significant reductions in various symptom parameters. Results of human clinical trials have not been consistently significant. Well-designed clinical trials are needed to substantiate or refute the potential benefit of fish oils in OA treatment. Long-term studies are needed to assess the possibility of prevention. In addition, standardization of the fish oil industry is needed for consistency of therapy. SN - 1934-3418 UR - https://www.unboundmedicine.com/medline/citation/26161757/full_citation L2 - http://www.amjorthopedics.com/the-publication/past-issue-single-view/fish-oil-and-osteoarthritis-current-evidence/0f24e75ea9d29852eeb71511c5da8a99.html DB - PRIME DP - Unbound Medicine ER -