Tags

Type your tag names separated by a space and hit enter

Azole susceptibility of Malassezia pachydermatis and Malassezia furfur and tentative epidemiological cut-off values.
Med Mycol. 2015 Sep; 53(7):743-8.MM

Abstract

This study aims to determine the minimal inhibitory concentration (MIC) distribution and the epidemiological cut-off values (ECVs) of Malassezia pachydermatis and Malassezia furfur isolates for fluconazole (FLZ), itraconazole (ITZ), posaconazole (POS), and voriconazole (VOR). A total of 62 M. pachydermatis strains from dogs with dermatitis and 78 M. furfur strains from humans with bloodstream infections (BSI) were tested by a modified broth microdilution Clinical and Laboratory Standards Institute (CLSI) method. ITZ and POS displayed lower MICs than VOR and FLZ, regardless of the Malassezia species. The MIC data for azoles of M. pachydermatis were four two-fold dilutions lower than those of M. furfur. Based on the ECVs, about 94% of Malassezia strains might be categorized within susceptible population for all azoles, except for FLZ, and azole cross-resistance was detected in association with FLZ in M. pachydermatis but not in M. furfur.The study proposes, for the first time, tentative azole ECVs for M. pachydermatis and M. furfur for monitoring the emergence of isolates with decreased susceptibilities and shows that the azole MIC distribution varied according to the Malassezia species tested, thus suggesting the usefulness of determining the susceptibility profile for effective treatment of each species.

Authors+Show Affiliations

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari "Aldo Moro", Italy claudia.cafarchia@uniba.it.Dipartimento di Medicina Veterinaria, Università degli Studi di Bari "Aldo Moro", Italy.Dipartimento di Medicina Veterinaria, Università degli Studi di Bari "Aldo Moro", Italy.Dipartimento di Medicina Veterinaria, Università degli Studi di Bari "Aldo Moro", Italy.Dipartimento di Medicina Veterinaria, Università degli Studi di Bari "Aldo Moro", Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26162472

Citation

Cafarchia, Claudia, et al. "Azole Susceptibility of Malassezia Pachydermatis and Malassezia Furfur and Tentative Epidemiological Cut-off Values." Medical Mycology, vol. 53, no. 7, 2015, pp. 743-8.
Cafarchia C, Iatta R, Immediato D, et al. Azole susceptibility of Malassezia pachydermatis and Malassezia furfur and tentative epidemiological cut-off values. Med Mycol. 2015;53(7):743-8.
Cafarchia, C., Iatta, R., Immediato, D., Puttilli, M. R., & Otranto, D. (2015). Azole susceptibility of Malassezia pachydermatis and Malassezia furfur and tentative epidemiological cut-off values. Medical Mycology, 53(7), 743-8. https://doi.org/10.1093/mmy/myv049
Cafarchia C, et al. Azole Susceptibility of Malassezia Pachydermatis and Malassezia Furfur and Tentative Epidemiological Cut-off Values. Med Mycol. 2015;53(7):743-8. PubMed PMID: 26162472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Azole susceptibility of Malassezia pachydermatis and Malassezia furfur and tentative epidemiological cut-off values. AU - Cafarchia,Claudia, AU - Iatta,Roberta, AU - Immediato,Davide, AU - Puttilli,Maria Rita, AU - Otranto,Domenico, Y1 - 2015/07/10/ PY - 2015/05/22/accepted PY - 2015/04/30/received PY - 2015/7/12/entrez PY - 2015/7/15/pubmed PY - 2016/5/24/medline KW - Azole susceptibility KW - Malassezia furfur KW - Malassezia pachydermatis KW - bloodstream infections KW - epidemiological cut-off values KW - skin SP - 743 EP - 8 JF - Medical mycology JO - Med. Mycol. VL - 53 IS - 7 N2 - This study aims to determine the minimal inhibitory concentration (MIC) distribution and the epidemiological cut-off values (ECVs) of Malassezia pachydermatis and Malassezia furfur isolates for fluconazole (FLZ), itraconazole (ITZ), posaconazole (POS), and voriconazole (VOR). A total of 62 M. pachydermatis strains from dogs with dermatitis and 78 M. furfur strains from humans with bloodstream infections (BSI) were tested by a modified broth microdilution Clinical and Laboratory Standards Institute (CLSI) method. ITZ and POS displayed lower MICs than VOR and FLZ, regardless of the Malassezia species. The MIC data for azoles of M. pachydermatis were four two-fold dilutions lower than those of M. furfur. Based on the ECVs, about 94% of Malassezia strains might be categorized within susceptible population for all azoles, except for FLZ, and azole cross-resistance was detected in association with FLZ in M. pachydermatis but not in M. furfur.The study proposes, for the first time, tentative azole ECVs for M. pachydermatis and M. furfur for monitoring the emergence of isolates with decreased susceptibilities and shows that the azole MIC distribution varied according to the Malassezia species tested, thus suggesting the usefulness of determining the susceptibility profile for effective treatment of each species. SN - 1460-2709 UR - https://www.unboundmedicine.com/medline/citation/26162472/Azole_susceptibility_of_Malassezia_pachydermatis_and_Malassezia_furfur_and_tentative_epidemiological_cut_off_values_ L2 - https://academic.oup.com/mmy/article-lookup/doi/10.1093/mmy/myv049 DB - PRIME DP - Unbound Medicine ER -