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Physiological Roles of Hydrogen Sulfide and Polysulfides.
Handb Exp Pharmacol. 2015; 230:61-81.HE

Abstract

Hydrogen sulfide (H2S) has been recognized as a signaling molecule as well as a cytoprotective molecule. H2S modulates neurotransmission, regulates vascular tone, protects various tissues and organs, regulates inflammation, induces angiogenesis, and detects cellular oxygen levels. H2S is produced from L-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT). Recently, a novel pathway for the production of H2S from D-cysteine was identified, involving D-amino acid oxidase (DAO) together with 3MST. Sulfuration (also called sulfhydration), which adds sulfur atoms to the cysteine residues of target proteins to modify protein activity, has been extensively studied as a mode of H2S action. Recently, hydrogen polysulfides (H2Sn, where n=3-7; n=2 is termed as persulfide) have been found to sulfurate target proteins in the brain, including transient receptor potential ankyrin 1 (TRPA1) channels, Kelch-like ECH-associating protein 1 (Keap1), and phosphatase and tensin homolog (PTEN), much more potently than H2S. The physiological stimuli that trigger the production of H2S and polysulfides, and the mechanisms maintaining their local levels, remain unknown. Understanding the regulation of H2Sn (including H2S) production, and the specific stimuli that induce their release, will provide new insight into the biology of H2S and will provide novel avenues for therapeutic development in diseases involving H2S-related substances.

Authors+Show Affiliations

National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan, kimura@ncnp.go.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26162829

Citation

Kimura, Hideo. "Physiological Roles of Hydrogen Sulfide and Polysulfides." Handbook of Experimental Pharmacology, vol. 230, 2015, pp. 61-81.
Kimura H. Physiological Roles of Hydrogen Sulfide and Polysulfides. Handb Exp Pharmacol. 2015;230:61-81.
Kimura, H. (2015). Physiological Roles of Hydrogen Sulfide and Polysulfides. Handbook of Experimental Pharmacology, 230, 61-81. https://doi.org/10.1007/978-3-319-18144-8_3
Kimura H. Physiological Roles of Hydrogen Sulfide and Polysulfides. Handb Exp Pharmacol. 2015;230:61-81. PubMed PMID: 26162829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological Roles of Hydrogen Sulfide and Polysulfides. A1 - Kimura,Hideo, PY - 2015/7/12/entrez PY - 2015/7/15/pubmed PY - 2015/11/10/medline SP - 61 EP - 81 JF - Handbook of experimental pharmacology JO - Handb Exp Pharmacol VL - 230 N2 - Hydrogen sulfide (H2S) has been recognized as a signaling molecule as well as a cytoprotective molecule. H2S modulates neurotransmission, regulates vascular tone, protects various tissues and organs, regulates inflammation, induces angiogenesis, and detects cellular oxygen levels. H2S is produced from L-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT). Recently, a novel pathway for the production of H2S from D-cysteine was identified, involving D-amino acid oxidase (DAO) together with 3MST. Sulfuration (also called sulfhydration), which adds sulfur atoms to the cysteine residues of target proteins to modify protein activity, has been extensively studied as a mode of H2S action. Recently, hydrogen polysulfides (H2Sn, where n=3-7; n=2 is termed as persulfide) have been found to sulfurate target proteins in the brain, including transient receptor potential ankyrin 1 (TRPA1) channels, Kelch-like ECH-associating protein 1 (Keap1), and phosphatase and tensin homolog (PTEN), much more potently than H2S. The physiological stimuli that trigger the production of H2S and polysulfides, and the mechanisms maintaining their local levels, remain unknown. Understanding the regulation of H2Sn (including H2S) production, and the specific stimuli that induce their release, will provide new insight into the biology of H2S and will provide novel avenues for therapeutic development in diseases involving H2S-related substances. SN - 0171-2004 UR - https://www.unboundmedicine.com/medline/citation/26162829/Physiological_Roles_of_Hydrogen_Sulfide_and_Polysulfides_ L2 - https://dx.doi.org/10.1007/978-3-319-18144-8_3 DB - PRIME DP - Unbound Medicine ER -