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The effect of endoscopic olfactory cleft polyp removal on olfaction.
Am J Rhinol Allergy. 2015 Jul-Aug; 29(4):309-13.AJ

Abstract

BACKGROUND

The presence of olfactory cleft polyps in chronic rhinosinusitis with nasal polyposis is well documented, but the effect of endoscopic olfactory cleft polyp surgery on olfaction, versus observation, has not been well studied. This analysis assessed if microdebridement of olfactory cleft polyps yields significant objective smell improvements in those with anosmia or hyposmia.

METHODS

A randomized prospective single-blinded study was performed on patients undergoing bilateral endoscopic sinus surgery with profound bilateral nasal polyposis, excluding those younger than 18 years or without olfactory polyps. A preoperative University of Pennsylvania Smell Identification Test (UPSIT), visual analog scale (VAS), and sinonasal outcomes 20 score (SNOT-20), and a follow-up at 6 months was performed. Two cohorts were created, including one with cleft polyp removal (group A) and one with cleft polyps left in place (group B).

RESULTS

There were 10 patients in group A and 7 in group B. By using the Wilcoxon signed rank test, the two groups were individually analyzed for changes in the preoperative UPSIT, VAS, and SNOT-20 versus the 6-month test results. In group A, the improvement in the UPSIT, VAS, and SNOT-20 were statistically significant at p < 0.05. For group B only the improvement in the VAS was statistically significant, at p < 0.05. There was a statistically significant difference in clinical smell improvement between group A and B at 6 months (p = 0.00512).

CONCLUSIONS

Evidence exists that olfactory cleft polyp surgery improves olfactory function outcomes. Long-term data beyond 6 months is needed to further validate these early promising outcomes.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26163252

Citation

Kuperan, Arjuna B., et al. "The Effect of Endoscopic Olfactory Cleft Polyp Removal On Olfaction." American Journal of Rhinology & Allergy, vol. 29, no. 4, 2015, pp. 309-13.
Kuperan AB, Lieberman SM, Jourdy DN, et al. The effect of endoscopic olfactory cleft polyp removal on olfaction. Am J Rhinol Allergy. 2015;29(4):309-13.
Kuperan, A. B., Lieberman, S. M., Jourdy, D. N., Al-Bar, M. H., Goldstein, B. J., & Casiano, R. R. (2015). The effect of endoscopic olfactory cleft polyp removal on olfaction. American Journal of Rhinology & Allergy, 29(4), 309-13. https://doi.org/10.2500/ajra.2015.29.4191
Kuperan AB, et al. The Effect of Endoscopic Olfactory Cleft Polyp Removal On Olfaction. Am J Rhinol Allergy. 2015 Jul-Aug;29(4):309-13. PubMed PMID: 26163252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of endoscopic olfactory cleft polyp removal on olfaction. AU - Kuperan,Arjuna B, AU - Lieberman,Seth M, AU - Jourdy,Deya N, AU - Al-Bar,Mohammad H, AU - Goldstein,Bradley J, AU - Casiano,Roy R, PY - 2015/7/12/entrez PY - 2015/7/15/pubmed PY - 2016/5/12/medline SP - 309 EP - 13 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 29 IS - 4 N2 - BACKGROUND: The presence of olfactory cleft polyps in chronic rhinosinusitis with nasal polyposis is well documented, but the effect of endoscopic olfactory cleft polyp surgery on olfaction, versus observation, has not been well studied. This analysis assessed if microdebridement of olfactory cleft polyps yields significant objective smell improvements in those with anosmia or hyposmia. METHODS: A randomized prospective single-blinded study was performed on patients undergoing bilateral endoscopic sinus surgery with profound bilateral nasal polyposis, excluding those younger than 18 years or without olfactory polyps. A preoperative University of Pennsylvania Smell Identification Test (UPSIT), visual analog scale (VAS), and sinonasal outcomes 20 score (SNOT-20), and a follow-up at 6 months was performed. Two cohorts were created, including one with cleft polyp removal (group A) and one with cleft polyps left in place (group B). RESULTS: There were 10 patients in group A and 7 in group B. By using the Wilcoxon signed rank test, the two groups were individually analyzed for changes in the preoperative UPSIT, VAS, and SNOT-20 versus the 6-month test results. In group A, the improvement in the UPSIT, VAS, and SNOT-20 were statistically significant at p < 0.05. For group B only the improvement in the VAS was statistically significant, at p < 0.05. There was a statistically significant difference in clinical smell improvement between group A and B at 6 months (p = 0.00512). CONCLUSIONS: Evidence exists that olfactory cleft polyp surgery improves olfactory function outcomes. Long-term data beyond 6 months is needed to further validate these early promising outcomes. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/26163252/The_effect_of_endoscopic_olfactory_cleft_polyp_removal_on_olfaction_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2015.29.4191?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -