Tags

Type your tag names separated by a space and hit enter

Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis.
Eur J Pharmacol 2016; 785:165-173EJ

Abstract

Omega-3 polyunsaturated fatty acids are essential for health and are known to possess anti-inflammatory properties, improving cardiovascular health as well as benefiting inflammatory diseases. Indeed, dietary supplementation with omega-3 polyunsaturated fatty acids has proved efficacious in reducing joint pain, morning stiffness and nonsteroidal anti-inflammatory drugs usage in rheumatoid arthritis patients. However, the mechanisms by which omega-3 polyunsaturated fatty acids exert their beneficial effects have not been fully explored. Seminal discoveries by Serhan and colleagues have unveiled a novel class of bioactive lipid mediators that are enzymatically biosynthesized in vivo from omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), termed resolvins, protectins and maresins. These bioactive pro-resolving lipid mediators provide further rationale for the beneficial effects of fish-oil enriched diets. These endogenous lipid mediators are spatiotemporally biosynthesized to actively regulate resolution by acting on specific G protein-coupled receptors (GPCRs) to initiate anti-inflammatory and pro-resolving signals that terminate inflammation. In this review, we will discuss the mechanism of actions of these molecules, including their analgesic and bone-sparing properties making them ideal therapeutic agonists for the treatment of inflammatory diseases such as rheumatoid arthritis.

Authors+Show Affiliations

The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom.The William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom. Electronic address: l.v.norling@qmul.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26165764

Citation

Souza, Patricia R., and Lucy V. Norling. "Implications for Eicosapentaenoic Acid- and Docosahexaenoic Acid-derived Resolvins as Therapeutics for Arthritis." European Journal of Pharmacology, vol. 785, 2016, pp. 165-173.
Souza PR, Norling LV. Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. Eur J Pharmacol. 2016;785:165-173.
Souza, P. R., & Norling, L. V. (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. European Journal of Pharmacology, 785, pp. 165-173. doi:10.1016/j.ejphar.2015.05.072.
Souza PR, Norling LV. Implications for Eicosapentaenoic Acid- and Docosahexaenoic Acid-derived Resolvins as Therapeutics for Arthritis. Eur J Pharmacol. 2016 Aug 15;785:165-173. PubMed PMID: 26165764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. AU - Souza,Patricia R, AU - Norling,Lucy V, Y1 - 2015/07/09/ PY - 2015/01/30/received PY - 2015/04/16/revised PY - 2015/05/11/accepted PY - 2015/7/14/entrez PY - 2015/7/15/pubmed PY - 2017/2/28/medline KW - Arthritis KW - Inflammation KW - Omega-3 KW - Resolution KW - Resolvins SP - 165 EP - 173 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 785 N2 - Omega-3 polyunsaturated fatty acids are essential for health and are known to possess anti-inflammatory properties, improving cardiovascular health as well as benefiting inflammatory diseases. Indeed, dietary supplementation with omega-3 polyunsaturated fatty acids has proved efficacious in reducing joint pain, morning stiffness and nonsteroidal anti-inflammatory drugs usage in rheumatoid arthritis patients. However, the mechanisms by which omega-3 polyunsaturated fatty acids exert their beneficial effects have not been fully explored. Seminal discoveries by Serhan and colleagues have unveiled a novel class of bioactive lipid mediators that are enzymatically biosynthesized in vivo from omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), termed resolvins, protectins and maresins. These bioactive pro-resolving lipid mediators provide further rationale for the beneficial effects of fish-oil enriched diets. These endogenous lipid mediators are spatiotemporally biosynthesized to actively regulate resolution by acting on specific G protein-coupled receptors (GPCRs) to initiate anti-inflammatory and pro-resolving signals that terminate inflammation. In this review, we will discuss the mechanism of actions of these molecules, including their analgesic and bone-sparing properties making them ideal therapeutic agonists for the treatment of inflammatory diseases such as rheumatoid arthritis. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/26165764/Implications_for_eicosapentaenoic_acid__and_docosahexaenoic_acid_derived_resolvins_as_therapeutics_for_arthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(15)30148-5 DB - PRIME DP - Unbound Medicine ER -