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Clinical significance of serum follistatin levels in the diagnosis of ovarian endometrioma and benign ovarian cysts.
Taiwan J Obstet Gynecol. 2015 Jun; 54(3):236-9.TJ

Abstract

OBJECTIVE

To determine the clinical significance of serum follistatin levels in women with an ovarian endometrioma.

MATERIALS AND METHODS

This is a prospective study of 89 women, 56 with an ovarian endometrioma (endometrioma group) and 33 with a benign ovarian cyst (control group) who underwent laparoscopic excision. Age, parity, body mass index, serum CA-125, serum CA 19-9, and serum follistatin levels were determined for all participants and evaluated as potential prognostic factors prior to laparoscopic cystectomy.

RESULTS

There were no significant differences in demographic factors between the endometrioma group and the control group. However, serum follistatin levels were significantly higher in the endometrioma group (9350 ± 895 pg/mL vs. control group 725 ± 72 pg/mL, p < 0.05). The optimal diagnostic cut-off values (sensitivity and specificity) of CA-125, CA 19-9, and follistatin for ovarian endometrioma were 23.2 IU/mL (82.14% and 72.73%), 30.14 IU/mL (45.28% and 87.50%), and 2350 pg/mL (53.7% and 60.61%), respectively.

CONCLUSION

Despite the increased serum follistatin levels in patients with ovarian endometrioma, CA-125 was determined to be a more sensitive and specific marker than follistatin for the diagnosis of ovarian endometrioma and endometriosis.

Authors+Show Affiliations

Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey. Electronic address: dronurtopcu@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26166333

Citation

Ant, Ömer, et al. "Clinical Significance of Serum Follistatin Levels in the Diagnosis of Ovarian Endometrioma and Benign Ovarian Cysts." Taiwanese Journal of Obstetrics & Gynecology, vol. 54, no. 3, 2015, pp. 236-9.
Ant Ö, Özakşit G, Güzel Aİ, et al. Clinical significance of serum follistatin levels in the diagnosis of ovarian endometrioma and benign ovarian cysts. Taiwan J Obstet Gynecol. 2015;54(3):236-9.
Ant, Ö., Özakşit, G., Güzel, A. İ., Cavkaytar, S., Kaba, M., & Topçu, H. O. (2015). Clinical significance of serum follistatin levels in the diagnosis of ovarian endometrioma and benign ovarian cysts. Taiwanese Journal of Obstetrics & Gynecology, 54(3), 236-9. https://doi.org/10.1016/j.tjog.2014.03.010
Ant Ö, et al. Clinical Significance of Serum Follistatin Levels in the Diagnosis of Ovarian Endometrioma and Benign Ovarian Cysts. Taiwan J Obstet Gynecol. 2015;54(3):236-9. PubMed PMID: 26166333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of serum follistatin levels in the diagnosis of ovarian endometrioma and benign ovarian cysts. AU - Ant,Ömer, AU - Özakşit,Gülnur, AU - Güzel,Ali İrfan, AU - Cavkaytar,Sabri, AU - Kaba,Metin, AU - Topçu,Hasan Onur, PY - 2014/03/17/accepted PY - 2015/7/14/entrez PY - 2015/7/15/pubmed PY - 2016/4/14/medline KW - CA 19-9 KW - CA-125 KW - diagnostic marker KW - endometriosis KW - follistatin SP - 236 EP - 9 JF - Taiwanese journal of obstetrics & gynecology JO - Taiwan J Obstet Gynecol VL - 54 IS - 3 N2 - OBJECTIVE: To determine the clinical significance of serum follistatin levels in women with an ovarian endometrioma. MATERIALS AND METHODS: This is a prospective study of 89 women, 56 with an ovarian endometrioma (endometrioma group) and 33 with a benign ovarian cyst (control group) who underwent laparoscopic excision. Age, parity, body mass index, serum CA-125, serum CA 19-9, and serum follistatin levels were determined for all participants and evaluated as potential prognostic factors prior to laparoscopic cystectomy. RESULTS: There were no significant differences in demographic factors between the endometrioma group and the control group. However, serum follistatin levels were significantly higher in the endometrioma group (9350 ± 895 pg/mL vs. control group 725 ± 72 pg/mL, p < 0.05). The optimal diagnostic cut-off values (sensitivity and specificity) of CA-125, CA 19-9, and follistatin for ovarian endometrioma were 23.2 IU/mL (82.14% and 72.73%), 30.14 IU/mL (45.28% and 87.50%), and 2350 pg/mL (53.7% and 60.61%), respectively. CONCLUSION: Despite the increased serum follistatin levels in patients with ovarian endometrioma, CA-125 was determined to be a more sensitive and specific marker than follistatin for the diagnosis of ovarian endometrioma and endometriosis. SN - 1875-6263 UR - https://www.unboundmedicine.com/medline/citation/26166333/Clinical_significance_of_serum_follistatin_levels_in_the_diagnosis_of_ovarian_endometrioma_and_benign_ovarian_cysts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1028-4559(15)00071-6 DB - PRIME DP - Unbound Medicine ER -