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Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial.
Eur J Nutr 2016; 55(4):1633-44EJ

Abstract

PURPOSE

Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status.

METHODS

Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids.

RESULTS

Complete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p < 0.001). In IG-R, levels of ALA and the ratio of ALA to LA in plasma and RBC (all p < 0.0001) as well as RBC-EPA (p < 0.0001) were higher than in CG, while DHA levels did not differ between IG-R and CG.

CONCLUSIONS

Regular fish consumption during complementary feeding enhances infant EPA and DHA status. The usage of rapeseed oil in small amounts concordant with EU-law for commercial meals enhances endogenic EPA-synthesis, but does not affect DHA status. Provision of oily fish with complementary feeds is advisable to prevent a decline of DHA status.

CLINICAL TRIAL REGISTRATION

www.clinicaltrials.gov , identifier: NCT01487889, title: Polyunsaturated fatty acids in child nutrition-a German multimodal optimisation study (PINGU).

Authors+Show Affiliations

Research Institute of Child Nutrition (FKE) Dortmund, University of Bonn, Heinstueck 11, 44225, Dortmund, Germany. libuda@fke-do.de.Research Institute of Child Nutrition (FKE) Dortmund, University of Bonn, Heinstueck 11, 44225, Dortmund, Germany.Research Institute of Child Nutrition (FKE) Dortmund, University of Bonn, Heinstueck 11, 44225, Dortmund, Germany.Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich Medical Centre, Munich, Germany.Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich Medical Centre, Munich, Germany.Department of Psychology, University of Potsdam, Potsdam, Germany.Pediatric Clinic Dortmund, Dortmund, Germany.Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munich, Munich, Germany.Pediatric Clinic Dortmund, Dortmund, Germany.Research Institute of Child Nutrition (FKE) Dortmund, University of Bonn, Heinstueck 11, 44225, Dortmund, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26169870

Citation

Libuda, Lars, et al. "Fatty Acid Supply With Complementary Foods and LC-PUFA Status in Healthy Infants: Results of a Randomised Controlled Trial." European Journal of Nutrition, vol. 55, no. 4, 2016, pp. 1633-44.
Libuda L, Mesch CM, Stimming M, et al. Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial. Eur J Nutr. 2016;55(4):1633-44.
Libuda, L., Mesch, C. M., Stimming, M., Demmelmair, H., Koletzko, B., Warschburger, P., ... Kersting, M. (2016). Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial. European Journal of Nutrition, 55(4), pp. 1633-44. doi:10.1007/s00394-015-0982-2.
Libuda L, et al. Fatty Acid Supply With Complementary Foods and LC-PUFA Status in Healthy Infants: Results of a Randomised Controlled Trial. Eur J Nutr. 2016;55(4):1633-44. PubMed PMID: 26169870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial. AU - Libuda,Lars, AU - Mesch,Christina M, AU - Stimming,Madlen, AU - Demmelmair,Hans, AU - Koletzko,Berthold, AU - Warschburger,Petra, AU - Blanke,Katharina, AU - Reischl,Eva, AU - Kalhoff,Hermann, AU - Kersting,Mathilde, Y1 - 2015/07/14/ PY - 2015/02/11/received PY - 2015/06/29/accepted PY - 2015/7/15/entrez PY - 2015/7/15/pubmed PY - 2017/3/23/medline KW - Alpha-linolenic acid KW - Complementary feeding KW - Complementary food KW - DHA KW - DHA status KW - Fish KW - Rapeseed oil SP - 1633 EP - 44 JF - European journal of nutrition JO - Eur J Nutr VL - 55 IS - 4 N2 - PURPOSE: Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status. METHODS: Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids. RESULTS: Complete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p < 0.001). In IG-R, levels of ALA and the ratio of ALA to LA in plasma and RBC (all p < 0.0001) as well as RBC-EPA (p < 0.0001) were higher than in CG, while DHA levels did not differ between IG-R and CG. CONCLUSIONS: Regular fish consumption during complementary feeding enhances infant EPA and DHA status. The usage of rapeseed oil in small amounts concordant with EU-law for commercial meals enhances endogenic EPA-synthesis, but does not affect DHA status. Provision of oily fish with complementary feeds is advisable to prevent a decline of DHA status. CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov , identifier: NCT01487889, title: Polyunsaturated fatty acids in child nutrition-a German multimodal optimisation study (PINGU). SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/26169870/Fatty_acid_supply_with_complementary_foods_and_LC_PUFA_status_in_healthy_infants:_results_of_a_randomised_controlled_trial_ L2 - https://dx.doi.org/10.1007/s00394-015-0982-2 DB - PRIME DP - Unbound Medicine ER -