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Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis.
Aging Male. 2015; 18(4):207-16.AM

Abstract

A significant amount of epidemiological evidences have underlined an emerging link between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement a (BPE). We aimed to assess the connections between LUTS and MetS with its components. Meta-analysis were conducted to determine the mean differences (MD) and confidence intervals of IPSS total score, IPSS-voiding, IPSS-storage and prostate volume (PV) in patients with or without MetS. Ln(odds-ratio) were calculated to estimate the risk of having moderate-to-severe LUTS (IPSS ≥ 8). Nineteen studies were identified as eligible for this systematic review, with a total of 18,476 participants, including 5554 (30.06%) with and 12,922 (69.94%) without MetS. Pooled analysis did not demonstrate significant MD of IPSS, IPSS-voiding and IPSS-storage in men with or without MetS but PV was significantly different (MD = 2.18; p = 0.03). Presence of MetS was not significantly associated with moderate-to-severe LUTS (odds ratio = 1.13; p = 0.53) and only altered serum triglycerides and diabetes were associated with this risk. The association between MetS and LUTS/BPE remain unclear and further observational studies in a population with metabolic disorders should be conducted in order to address it's potential role in determining LUTS/BPE.

Authors+Show Affiliations

a Department of Urology and.a Department of Urology and.a Department of Urology and.a Department of Urology and.a Department of Urology and.b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.b Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology, and Internal Medicine , University of Catania , Catania , Italy.a Department of Urology and.a Department of Urology and.a Department of Urology and.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26171768

Citation

Russo, Giorgio Ivan, et al. "Connections Between Lower Urinary Tract Symptoms Related to Benign Prostatic Enlargement and Metabolic Syndrome With Its Components: a Systematic Review and Meta-analysis." The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, vol. 18, no. 4, 2015, pp. 207-16.
Russo GI, Castelli T, Urzì D, et al. Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. Aging Male. 2015;18(4):207-16.
Russo, G. I., Castelli, T., Urzì, D., Privitera, S., Fragalà, E., La Vignera, S., Condorelli, R. A., Calogero, A. E., Favilla, V., Cimino, S., & Morgia, G. (2015). Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 18(4), 207-16. https://doi.org/10.3109/13685538.2015.1062980
Russo GI, et al. Connections Between Lower Urinary Tract Symptoms Related to Benign Prostatic Enlargement and Metabolic Syndrome With Its Components: a Systematic Review and Meta-analysis. Aging Male. 2015;18(4):207-16. PubMed PMID: 26171768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. AU - Russo,Giorgio Ivan, AU - Castelli,Tommaso, AU - Urzì,Daniele, AU - Privitera,Salvatore, AU - Fragalà,Eugenia, AU - La Vignera,Sandro, AU - Condorelli,Rosita A, AU - Calogero,Aldo E, AU - Favilla,Vincenzo, AU - Cimino,Sebastiano, AU - Morgia,Giuseppe, Y1 - 2015/07/14/ PY - 2015/7/15/entrez PY - 2015/7/15/pubmed PY - 2016/9/10/medline KW - Age KW - LUTS KW - benign prostatic enlargement KW - insulin resistance KW - metabolic syndrome KW - non-alcholic fatty liver disease KW - prostate KW - testosterone SP - 207 EP - 16 JF - The aging male : the official journal of the International Society for the Study of the Aging Male JO - Aging Male VL - 18 IS - 4 N2 - A significant amount of epidemiological evidences have underlined an emerging link between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement a (BPE). We aimed to assess the connections between LUTS and MetS with its components. Meta-analysis were conducted to determine the mean differences (MD) and confidence intervals of IPSS total score, IPSS-voiding, IPSS-storage and prostate volume (PV) in patients with or without MetS. Ln(odds-ratio) were calculated to estimate the risk of having moderate-to-severe LUTS (IPSS ≥ 8). Nineteen studies were identified as eligible for this systematic review, with a total of 18,476 participants, including 5554 (30.06%) with and 12,922 (69.94%) without MetS. Pooled analysis did not demonstrate significant MD of IPSS, IPSS-voiding and IPSS-storage in men with or without MetS but PV was significantly different (MD = 2.18; p = 0.03). Presence of MetS was not significantly associated with moderate-to-severe LUTS (odds ratio = 1.13; p = 0.53) and only altered serum triglycerides and diabetes were associated with this risk. The association between MetS and LUTS/BPE remain unclear and further observational studies in a population with metabolic disorders should be conducted in order to address it's potential role in determining LUTS/BPE. SN - 1473-0790 UR - https://www.unboundmedicine.com/medline/citation/26171768/Connections_between_lower_urinary_tract_symptoms_related_to_benign_prostatic_enlargement_and_metabolic_syndrome_with_its_components:_a_systematic_review_and_meta_analysis_ L2 - https://www.tandfonline.com/doi/full/10.3109/13685538.2015.1062980 DB - PRIME DP - Unbound Medicine ER -