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Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias.
Respir Med. 2015 Aug; 109(8):1063-8.RM

Abstract

INTRODUCTION

Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) has important therapeutic and prognostic implications and would be greatly aided by reliable diagnostic biomarkers as IPF has sometimes overlapping features with other interstitial lung diseases (ILD).

OBJECTIVES

To explore the value of serum metalloproteinases (MMP) 1 and 7 levels in the differential diagnosis of IPF with other ILD.

METHODS

MMP-1/7 serum levels were measured using Luminex xMAP technology in 139 patients- 47 IPF, 36 non-IPF Usual Interstitial Pneumonia (UIP), 14 idiopathic Nonspecific Interstitial Pneumonia (iNSIP), 29 secondary NSIP (secNSIP), 13 stage IV sarcoidosis- and 20 healthy controls, and compared using the Mann-Whitney U test.

RESULTS

MMP-1 was significantly higher in IPF than non-IPF UIP (P = .042) and sarcoidosis (P = .027). MMP-7 was significantly higher in IPF than controls (P < .001), non-IPF UIP (P = .003), secNSIP (P < .001), and sarcoidosis (P < .001). The Area Under the Curve for IPF versus other ILD was 0.63 (95%CI, 0.53-0.73) for MMP-1, 0.73 (95%CI, 0.65-0.81) for MMP-7, and 0.74 (95%CI, 0.66-0.82) for MMP-1/MMP-7 combined. Sensitivity and specificity for MMP-7 cutoff = 3.91 ng/mL was 72.3% and 66.3%, respectively, Positive Predictive Values = 52.3% and Negative Predictive Values = 82.4%.

CONCLUSIONS

MMP-1 and particularly MMP-7 serum levels were significantly higher in IPF than in non-IPF UIP, the main entity in differential diagnosis. The value of these biomarkers as additional tools in a multidisciplinary approach to IPF diagnosis needs to be considered and further explored.

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Authors+Show Affiliations

Morais A
Pneumology Department, Centro Hospitalar São João, Faculdade de Medicina, Universidade do Porto, Portugal. Electronic address: antonio.morais16@outlook.com.
Beltrão M
Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculdade de Medicina, Universidade do Porto, Portugal.
Sokhatska O
Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculdade de Medicina, Universidade do Porto, Portugal.
Costa D
Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculdade de Medicina, Portugal; EPIUnit-Institute of Public Health, Universidade do Porto, Portugal.
Melo N
Pneumology Department, Centro Hospitalar São João, Faculdade de Medicina, Universidade do Porto, Portugal.
Mota P
Pneumology Department, Centro Hospitalar São João, Faculdade de Medicina, Universidade do Porto, Portugal.
Marques A
Pneumology Department, Centro Hospitalar São João, Faculdade de Medicina, Universidade do Porto, Portugal.
Delgado L
Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculdade de Medicina, Universidade do Porto, Portugal; Centre for Research in Health Technologies and Information Systems (CINTESIS), University of Porto, Portugal.

MeSH

AgedBiomarkersDiagnosis, DifferentialEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansIdiopathic Interstitial PneumoniasIdiopathic Pulmonary FibrosisMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 7Middle AgedPredictive Value of TestsPrognosisReproducibility of ResultsRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26174192

Citation

Morais, António, et al. "Serum Metalloproteinases 1 and 7 in the Diagnosis of Idiopathic Pulmonary Fibrosis and Other Interstitial Pneumonias." Respiratory Medicine, vol. 109, no. 8, 2015, pp. 1063-8.
Morais A, Beltrão M, Sokhatska O, et al. Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias. Respir Med. 2015;109(8):1063-8.
Morais, A., Beltrão, M., Sokhatska, O., Costa, D., Melo, N., Mota, P., Marques, A., & Delgado, L. (2015). Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias. Respiratory Medicine, 109(8), 1063-8. https://doi.org/10.1016/j.rmed.2015.06.003
Morais A, et al. Serum Metalloproteinases 1 and 7 in the Diagnosis of Idiopathic Pulmonary Fibrosis and Other Interstitial Pneumonias. Respir Med. 2015;109(8):1063-8. PubMed PMID: 26174192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias. AU - Morais,António, AU - Beltrão,Marília, AU - Sokhatska,Oksana, AU - Costa,Diogo, AU - Melo,Natalia, AU - Mota,Patricia, AU - Marques,Agostinho, AU - Delgado,Luís, Y1 - 2015/06/12/ PY - 2015/04/09/received PY - 2015/06/08/revised PY - 2015/06/08/accepted PY - 2015/7/16/entrez PY - 2015/7/16/pubmed PY - 2016/5/4/medline KW - Idiopathic interstitial pneumonias KW - Idiopathic pulmonary fibrosis KW - Metalloproteinase 1 KW - Metalloproteinase 7 KW - Metalloproteinases KW - Sarcoidosis SP - 1063 EP - 8 JF - Respiratory medicine JO - Respir Med VL - 109 IS - 8 N2 - INTRODUCTION: Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) has important therapeutic and prognostic implications and would be greatly aided by reliable diagnostic biomarkers as IPF has sometimes overlapping features with other interstitial lung diseases (ILD). OBJECTIVES: To explore the value of serum metalloproteinases (MMP) 1 and 7 levels in the differential diagnosis of IPF with other ILD. METHODS: MMP-1/7 serum levels were measured using Luminex xMAP technology in 139 patients- 47 IPF, 36 non-IPF Usual Interstitial Pneumonia (UIP), 14 idiopathic Nonspecific Interstitial Pneumonia (iNSIP), 29 secondary NSIP (secNSIP), 13 stage IV sarcoidosis- and 20 healthy controls, and compared using the Mann-Whitney U test. RESULTS: MMP-1 was significantly higher in IPF than non-IPF UIP (P = .042) and sarcoidosis (P = .027). MMP-7 was significantly higher in IPF than controls (P < .001), non-IPF UIP (P = .003), secNSIP (P < .001), and sarcoidosis (P < .001). The Area Under the Curve for IPF versus other ILD was 0.63 (95%CI, 0.53-0.73) for MMP-1, 0.73 (95%CI, 0.65-0.81) for MMP-7, and 0.74 (95%CI, 0.66-0.82) for MMP-1/MMP-7 combined. Sensitivity and specificity for MMP-7 cutoff = 3.91 ng/mL was 72.3% and 66.3%, respectively, Positive Predictive Values = 52.3% and Negative Predictive Values = 82.4%. CONCLUSIONS: MMP-1 and particularly MMP-7 serum levels were significantly higher in IPF than in non-IPF UIP, the main entity in differential diagnosis. The value of these biomarkers as additional tools in a multidisciplinary approach to IPF diagnosis needs to be considered and further explored. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/26174192/Serum_metalloproteinases_1_and_7_in_the_diagnosis_of_idiopathic_pulmonary_fibrosis_and_other_interstitial_pneumonias_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(15)30007-X DB - PRIME DP - Unbound Medicine ER -