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Correlation between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients with pNO Esophageal Squamous Cell Carcinomas.
Hepatogastroenterology. 2014 May; 61(131):671-7.H

Abstract

BACKGROUND/AIMS

The purpose of this study was to investigate the correlation between vascular endothelial growth factor C expression and lymph node micrometastasis and prognosis in patients with pN0 esophageal squamous cell carcinoma.

METHODOLOGY

A total of 528 lymph nodes obtained from the 87 patients with pN0 esophageal squamous cell carcinoma who underwent Ivor-Lewis esophagectomy were reevaluated by reverse transcriptasepolymerase chain reaction to detect mucin 1 mRNA. Vascular endothelial growth factor C mRNA was detected in esophageal cancer issues also by re-evaluated by reverse transcriptasepolymerase chain reaction.

RESULTS

Vascular endothelial growth factor C mRNA expression was correlated with tumor invasion (P < 0.01) and lymphatic invasion (P = 0.000). In univariate analysis by log-rank test, the 5-year survival rate in patients after operation was significantly associated with tumor invasion (P = 0.026), mucin 1 mRNA expression (P = 0.000) and vascular endothelial growth factor C mRNA expression (P = 0.020). The results of Cox regression multivariate analysis confirmed that tumor invasion status and mucin 1 mRNA expression were the independent relevant factors.

CONCLUSION

Expression of vascular endothelial growth factor C is related to tumor invasion and lymphatic invasion and is not related to lymph node micrometastasis in patients with pN0 esophageal squamous cell carcinoma.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26176055

Citation

Sun, Zlhi-Gang, et al. "Correlation Between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients With pNO Esophageal Squamous Cell Carcinomas." Hepato-gastroenterology, vol. 61, no. 131, 2014, pp. 671-7.
Sun ZG, Liu XY, Zhang M, et al. Correlation between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients with pNO Esophageal Squamous Cell Carcinomas. Hepatogastroenterology. 2014;61(131):671-7.
Sun, Z. G., Liu, X. Y., Zhang, M., & Wang, Z. (2014). Correlation between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients with pNO Esophageal Squamous Cell Carcinomas. Hepato-gastroenterology, 61(131), 671-7.
Sun ZG, et al. Correlation Between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients With pNO Esophageal Squamous Cell Carcinomas. Hepatogastroenterology. 2014;61(131):671-7. PubMed PMID: 26176055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between Vascular Endothelial Growth Factor C Expressior and Lymph Node Micrometastasis and Prognosis in Patients with pNO Esophageal Squamous Cell Carcinomas. AU - Sun,Zlhi-Gang, AU - Liu,Xiang-Yan, AU - Zhang,Min, AU - Wang,Zhou, PY - 2015/7/16/entrez PY - 2014/5/1/pubmed PY - 2015/8/13/medline SP - 671 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 61 IS - 131 N2 - BACKGROUND/AIMS: The purpose of this study was to investigate the correlation between vascular endothelial growth factor C expression and lymph node micrometastasis and prognosis in patients with pN0 esophageal squamous cell carcinoma. METHODOLOGY: A total of 528 lymph nodes obtained from the 87 patients with pN0 esophageal squamous cell carcinoma who underwent Ivor-Lewis esophagectomy were reevaluated by reverse transcriptasepolymerase chain reaction to detect mucin 1 mRNA. Vascular endothelial growth factor C mRNA was detected in esophageal cancer issues also by re-evaluated by reverse transcriptasepolymerase chain reaction. RESULTS: Vascular endothelial growth factor C mRNA expression was correlated with tumor invasion (P < 0.01) and lymphatic invasion (P = 0.000). In univariate analysis by log-rank test, the 5-year survival rate in patients after operation was significantly associated with tumor invasion (P = 0.026), mucin 1 mRNA expression (P = 0.000) and vascular endothelial growth factor C mRNA expression (P = 0.020). The results of Cox regression multivariate analysis confirmed that tumor invasion status and mucin 1 mRNA expression were the independent relevant factors. CONCLUSION: Expression of vascular endothelial growth factor C is related to tumor invasion and lymphatic invasion and is not related to lymph node micrometastasis in patients with pN0 esophageal squamous cell carcinoma. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/26176055/Correlation_between_Vascular_Endothelial_Growth_Factor_C_Expressior_and_Lymph_Node_Micrometastasis_and_Prognosis_in_Patients_with_pNO_Esophageal_Squamous_Cell_Carcinomas_ L2 - https://medlineplus.gov/esophagealcancer.html DB - PRIME DP - Unbound Medicine ER -