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Obesity and inflammatory biomarkers in women with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2015 Sep; 192:66-71.EJ

Abstract

OBJECTIVE

To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS.

STUDY DESIGN

Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured.

RESULTS

Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL.

CONCLUSIONS

The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: hsumingi@yahoo.com.tw.Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.Institute for Labor Research, National Chengchi University, Taipei, Taiwan.Department of Obstetrics and Gynaecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.Department of Obstetrics and Gynaecology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26177495

Citation

Shen, Szu-Hung, et al. "Obesity and Inflammatory Biomarkers in Women With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 192, 2015, pp. 66-71.
Shen SH, Shen SY, Liou TH, et al. Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2015;192:66-71.
Shen, S. H., Shen, S. Y., Liou, T. H., Hsu, M. I., Chang, Y. C., Cheng, C. Y., Hsu, C. S., & Tzeng, C. R. (2015). Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 192, 66-71. https://doi.org/10.1016/j.ejogrb.2015.06.022
Shen SH, et al. Obesity and Inflammatory Biomarkers in Women With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2015;192:66-71. PubMed PMID: 26177495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. AU - Shen,Szu-Hung, AU - Shen,Szu-Yu, AU - Liou,Tsan-Hon, AU - Hsu,Ming-I, AU - Chang,Yuan-chin Ivan, AU - Cheng,Chih-Yu, AU - Hsu,Chun-Sen, AU - Tzeng,Chii-Ruey, Y1 - 2015/07/02/ PY - 2014/07/01/received PY - 2015/06/13/revised PY - 2015/06/24/accepted PY - 2015/7/16/entrez PY - 2015/7/16/pubmed PY - 2016/5/21/medline KW - Adiponectin KW - Inflammation KW - Leptin KW - Obesity KW - PCOS KW - Resistin SP - 66 EP - 71 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 192 N2 - OBJECTIVE: To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. STUDY DESIGN: Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. RESULTS: Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. CONCLUSIONS: The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/26177495/Obesity_and_inflammatory_biomarkers_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(15)00205-5 DB - PRIME DP - Unbound Medicine ER -