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Dietary advanced glycation end products and their role in health and disease.
Adv Nutr 2015; 6(4):461-73AN

Abstract

Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and inflammation, processes that play a major role in the causation of chronic diseases. A 3-d symposium (1st Latin American Symposium of AGEs) to discuss this subject took place in Guanajuato, Mexico, on 1-3 October 2014 with the participation of researchers from several countries. This review is a summary of the different presentations and subjects discussed, and it is divided into 4 sections. The first section deals with current general knowledge about AGEs. The second section dwells on mechanisms of action of AGEs, with special emphasis on the receptor for advanced glycation end products and the potential role of AGEs in neurodegenerative diseases. The third section discusses different approaches to decrease the AGE burden. The last section discusses current methodologic problems with measurement of AGEs in different samples. The subject under discussion is complex and extensive and cannot be completely covered in a short review. Therefore, some areas of interest have been left out because of space. However, we hope this review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.

Authors+Show Affiliations

Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY; Jaime.uribarri@mssm.edu.Food Bioscience Group, Department of Food Analysis and Bioactivity, Institute of Food Science Research, Spanish National Research Council, Madrid, Spain;Institute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros, University of Chile, Santiago, Chile;Department of Pharmacognosy, Institute of Drug Chemistry and Metabolism, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina;College of Osteopathic Medicine, Touro University California, Vallejo, CA;Medical Science Department, University of Guanajuato, Guanajuato, Mexico;Medical Science Department, University of Guanajuato, Guanajuato, Mexico;Nutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil;Food Science and Technology Department, School of Chemistry, University of the Republic, Montevideo, Uruguay;College of Osteopathic Medicine, Touro University California, Vallejo, CA;Metabolic Pathophysiology Department, School of Medicine, Biomedical Research Institute of Lleida, University of Lleida, Lleida, Spain;Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, Talca, Chile; and.Nutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil;Chemistry Department, University of Guanajuato, Guanajuato, Mexico.Chemistry Department, University of Guanajuato, Guanajuato, Mexico.Medical Science Department, University of Guanajuato, Guanajuato, Mexico;

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26178030

Citation

Uribarri, Jaime, et al. "Dietary Advanced Glycation End Products and Their Role in Health and Disease." Advances in Nutrition (Bethesda, Md.), vol. 6, no. 4, 2015, pp. 461-73.
Uribarri J, del Castillo MD, de la Maza MP, et al. Dietary advanced glycation end products and their role in health and disease. Adv Nutr. 2015;6(4):461-73.
Uribarri, J., del Castillo, M. D., de la Maza, M. P., Filip, R., Gugliucci, A., Luevano-Contreras, C., ... Garay-Sevilla, M. E. (2015). Dietary advanced glycation end products and their role in health and disease. Advances in Nutrition (Bethesda, Md.), 6(4), pp. 461-73. doi:10.3945/an.115.008433.
Uribarri J, et al. Dietary Advanced Glycation End Products and Their Role in Health and Disease. Adv Nutr. 2015;6(4):461-73. PubMed PMID: 26178030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary advanced glycation end products and their role in health and disease. AU - Uribarri,Jaime, AU - del Castillo,María Dolores, AU - de la Maza,María Pía, AU - Filip,Rosana, AU - Gugliucci,Alejandro, AU - Luevano-Contreras,Claudia, AU - Macías-Cervantes,Maciste H, AU - Markowicz Bastos,Deborah H, AU - Medrano,Alejandra, AU - Menini,Teresita, AU - Portero-Otin,Manuel, AU - Rojas,Armando, AU - Sampaio,Geni Rodrigues, AU - Wrobel,Kazimierz, AU - Wrobel,Katarzyna, AU - Garay-Sevilla,Ma Eugenia, Y1 - 2015/07/15/ PY - 2015/7/17/entrez PY - 2015/7/17/pubmed PY - 2016/4/14/medline KW - RAGE KW - inflammation KW - insulin resistance KW - nutraceutical KW - nutrition KW - oxidative stress SP - 461 EP - 73 JF - Advances in nutrition (Bethesda, Md.) JO - Adv Nutr VL - 6 IS - 4 N2 - Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and inflammation, processes that play a major role in the causation of chronic diseases. A 3-d symposium (1st Latin American Symposium of AGEs) to discuss this subject took place in Guanajuato, Mexico, on 1-3 October 2014 with the participation of researchers from several countries. This review is a summary of the different presentations and subjects discussed, and it is divided into 4 sections. The first section deals with current general knowledge about AGEs. The second section dwells on mechanisms of action of AGEs, with special emphasis on the receptor for advanced glycation end products and the potential role of AGEs in neurodegenerative diseases. The third section discusses different approaches to decrease the AGE burden. The last section discusses current methodologic problems with measurement of AGEs in different samples. The subject under discussion is complex and extensive and cannot be completely covered in a short review. Therefore, some areas of interest have been left out because of space. However, we hope this review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research. SN - 2156-5376 UR - https://www.unboundmedicine.com/medline/citation/26178030/Dietary_advanced_glycation_end_products_and_their_role_in_health_and_disease_ L2 - https://academic.oup.com/advances/article-lookup/doi/10.3945/an.115.008433 DB - PRIME DP - Unbound Medicine ER -