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Serum Vitamin D Concentrations Are Not Associated with Insulin Resistance in Swiss Adults.
J Nutr. 2015 Sep; 145(9):2117-22.JN

Abstract

BACKGROUND

Low vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned.

OBJECTIVE

We examined the association between serum vitamin D metabolites and incident IR.

METHODS

This was a prospective, population-based study derived from the CoLaus (Cohorte Lausannoise) study including 3856 participants (aged 51.2 ± 10.4 y; 2217 women) free from diabetes or IR at baseline. IR was defined as a homeostasis model assessment (HOMA) index >2.6. Fasting plasma insulin and glucose were measured at baseline and at follow-up to calculate the HOMA index. The association of vitamin D metabolites with incident IR was analyzed by logistic regression, and the results were expressed for each independent variable as ORs and 95% CIs.

RESULTS

During the 5.5-y follow-up, 649 (16.9%) incident cases of IR were identified. Participants who developed IR had lower baseline serum concentrations of 25-hydroxyvitamin D3 [25(OH)D3 (25-hydroxycholecalciferol); 45.9 ± 22.8 vs. 49.9 ± 22.6 nmol/L; P < 0.001], total 25(OH)D3 (25(OH)D3 + epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3]; 49.1 ± 24.3 vs. 53.3 ± 24.1 nmol/L; P < 0.001), and 3-epi-25(OH)D3 (4.2 ± 2.9 vs. 4.3 ± 2.5 nmol/L; P = 0.01) but a higher 3-epi- to total 25(OH)D3 ratio (0.09 ± 0.05 vs. 0.08 ± 0.04; P = 0.007). Multivariable analysis adjusting for month of sampling, age, and sex showed an inverse association between 25(OH)D3 and the likelihood of developing IR [ORs (95% CIs): 0.86 (0.68, 1.09), 0.60 (0.46, 0.78), and 0.57 (0.43, 0.75) for the second, third, and fourth quartiles compared with the first 25(OH)D3 quartile; P-trend < 0.001]. Similar associations were found between total 25(OH)D3 and incident IR. There was no significant association between 3-epi-25(OH)D3 and IR, yet a positive association was observed between the 3-epi- to total 25(OH)D3 ratio and incident IR. Further adjustment for body mass index, sedentary status, and smoking attenuated the association between 25(OH)D3, total 25(OH)D3, and the 3-epi- to total 25(OH)D3 ratio and the likelihood of developing IR.

CONCLUSION

In the CoLaus study in healthy adults, the risk of incident IR is not associated with serum concentrations of 25(OH)D3 and total 25(OH)D3.

Authors+Show Affiliations

Department of Internal Medicine.Department of Internal Medicine.Institute of Social and Preventive Medicine (IUMSP), Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; and Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.Department of Laboratory Medicine, and.Department of Laboratory Medicine, and.Department of Internal Medicine.Service of Endocrinology, Diabetes, and Metabolism, Lausanne University Hospital, Lausanne, Switzerland; francois.jornayvaz@chuv.ch.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26180247

Citation

Marques-Vidal, Pedro, et al. "Serum Vitamin D Concentrations Are Not Associated With Insulin Resistance in Swiss Adults." The Journal of Nutrition, vol. 145, no. 9, 2015, pp. 2117-22.
Marques-Vidal P, Vollenweider P, Guessous I, et al. Serum Vitamin D Concentrations Are Not Associated with Insulin Resistance in Swiss Adults. J Nutr. 2015;145(9):2117-22.
Marques-Vidal, P., Vollenweider, P., Guessous, I., Henry, H., Boulat, O., Waeber, G., & Jornayvaz, F. R. (2015). Serum Vitamin D Concentrations Are Not Associated with Insulin Resistance in Swiss Adults. The Journal of Nutrition, 145(9), 2117-22. https://doi.org/10.3945/jn.115.211763
Marques-Vidal P, et al. Serum Vitamin D Concentrations Are Not Associated With Insulin Resistance in Swiss Adults. J Nutr. 2015;145(9):2117-22. PubMed PMID: 26180247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum Vitamin D Concentrations Are Not Associated with Insulin Resistance in Swiss Adults. AU - Marques-Vidal,Pedro, AU - Vollenweider,Peter, AU - Guessous,Idris, AU - Henry,Hugues, AU - Boulat,Olivier, AU - Waeber,Gérard, AU - Jornayvaz,François R, Y1 - 2015/07/15/ PY - 2015/02/05/received PY - 2015/06/25/accepted PY - 2015/7/17/entrez PY - 2015/7/17/pubmed PY - 2015/12/15/medline KW - HOMA KW - body mass index KW - insulin resistance KW - prospective study KW - type 2 diabetes KW - vitamin D SP - 2117 EP - 22 JF - The Journal of nutrition JO - J Nutr VL - 145 IS - 9 N2 - BACKGROUND: Low vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned. OBJECTIVE: We examined the association between serum vitamin D metabolites and incident IR. METHODS: This was a prospective, population-based study derived from the CoLaus (Cohorte Lausannoise) study including 3856 participants (aged 51.2 ± 10.4 y; 2217 women) free from diabetes or IR at baseline. IR was defined as a homeostasis model assessment (HOMA) index >2.6. Fasting plasma insulin and glucose were measured at baseline and at follow-up to calculate the HOMA index. The association of vitamin D metabolites with incident IR was analyzed by logistic regression, and the results were expressed for each independent variable as ORs and 95% CIs. RESULTS: During the 5.5-y follow-up, 649 (16.9%) incident cases of IR were identified. Participants who developed IR had lower baseline serum concentrations of 25-hydroxyvitamin D3 [25(OH)D3 (25-hydroxycholecalciferol); 45.9 ± 22.8 vs. 49.9 ± 22.6 nmol/L; P < 0.001], total 25(OH)D3 (25(OH)D3 + epi-25-hydroxyvitamin D3 [3-epi-25(OH)D3]; 49.1 ± 24.3 vs. 53.3 ± 24.1 nmol/L; P < 0.001), and 3-epi-25(OH)D3 (4.2 ± 2.9 vs. 4.3 ± 2.5 nmol/L; P = 0.01) but a higher 3-epi- to total 25(OH)D3 ratio (0.09 ± 0.05 vs. 0.08 ± 0.04; P = 0.007). Multivariable analysis adjusting for month of sampling, age, and sex showed an inverse association between 25(OH)D3 and the likelihood of developing IR [ORs (95% CIs): 0.86 (0.68, 1.09), 0.60 (0.46, 0.78), and 0.57 (0.43, 0.75) for the second, third, and fourth quartiles compared with the first 25(OH)D3 quartile; P-trend < 0.001]. Similar associations were found between total 25(OH)D3 and incident IR. There was no significant association between 3-epi-25(OH)D3 and IR, yet a positive association was observed between the 3-epi- to total 25(OH)D3 ratio and incident IR. Further adjustment for body mass index, sedentary status, and smoking attenuated the association between 25(OH)D3, total 25(OH)D3, and the 3-epi- to total 25(OH)D3 ratio and the likelihood of developing IR. CONCLUSION: In the CoLaus study in healthy adults, the risk of incident IR is not associated with serum concentrations of 25(OH)D3 and total 25(OH)D3. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/26180247/Serum_Vitamin_D_Concentrations_Are_Not_Associated_with_Insulin_Resistance_in_Swiss_Adults_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.115.211763 DB - PRIME DP - Unbound Medicine ER -