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Population-Based Assessment of Determining Treatments for Prostate Cancer.

Abstract

IMPORTANCE

Many men with indolent prostate cancer often opt for radical prostatectomy or radiotherapy treatment for their disease. These men may experience considerable detriments of quality of life owing to sexual, urinary, and/or rectal toxic effects associated with these treatments. Without a better understanding of the mutable agents and predictors of treatment types, diffusion of expectant management among these men will be slow.

OBJECTIVE

To determine population-based predictors for treatment and use of watchful waiting or active surveillance for indolent prostate cancer.

DESIGN, SETTING, AND PARTICIPANTS

We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. A total of 37,621 men in the general community diagnosed as having prostate cancer from 2004 to 2007 were followed until December 31, 2009.

EXPOSURES

Watchful waiting or active surveillance, radiation therapy, or radical prostatectomy.

MAIN OUTCOMES AND MEASURES

We used mixed-effects logistic regression analysis to determine the factors associated with aggressive treatment and use of watchful waiting or active surveillance for men with prostate cancer.

RESULTS

The most common treatment type is radiation therapy (57.9% [95% CI, 57.4%-58.4%]), followed by radical prostatectomy (19.1% [95% CI, 18.7%-19.5%]) and watchful waiting or active surveillance (9.6% [95% CI, 9.3%-9.9%]). Moreover, patients and providers significantly integrate age (odds ratio [OR], 0.32 [95% CI, 0.29-0.35]) and comorbidities (OR, 0.62 [95% CI, 0.56-0.68]) when determining radical prostatectomy, while regional variation (OR, 0.57 [95% CI, 0.47-0.68]) and referral patterns (OR, 44.46 [95% CI, 41.04-48.17]) influence the use of radiation therapy. Patient demographics and tumor characteristics significantly account for 40% of patients undergoing prostatectomy, 12% choosing watchful waiting or active surveillance, and only 3% undergoing radiotherapy.

CONCLUSIONS AND RELEVANCE

There is increased use of radiotherapy among patients with indolent prostate cancer with limited to no correlation with tumor biology. Active surveillance was underused, and a significant proportion of the variance was unexplained. Further research into qualitatively describing the contributing factors that drive decision-making recommendations for prostate cancer patients is needed.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Urology, David Geffen School of Medicine at University of California, Los Angeles.

    ,

    Department of Urology, The University of Texas MD Anderson Cancer Center, Houston.

    Department of Urology, David Geffen School of Medicine at University of California, Los Angeles.

    Source

    JAMA oncology 1:1 2015 Apr pg 60-7

    MeSH

    Aged
    Aged, 80 and over
    Chi-Square Distribution
    Guideline Adherence
    Humans
    Kallikreins
    Logistic Models
    Male
    Medicare
    Multivariate Analysis
    Neoplasm Grading
    Neoplasm Staging
    Odds Ratio
    Population Surveillance
    Practice Guidelines as Topic
    Practice Patterns, Physicians'
    Prostate-Specific Antigen
    Prostatectomy
    Prostatic Neoplasms
    Quality Indicators, Health Care
    Radiotherapy
    Risk Assessment
    Risk Factors
    SEER Program
    Time Factors
    Treatment Outcome
    United States
    Watchful Waiting

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    26182305

    Citation

    Chamie, Karim, et al. "Population-Based Assessment of Determining Treatments for Prostate Cancer." JAMA Oncology, vol. 1, no. 1, 2015, pp. 60-7.
    Chamie K, Williams SB, Hu JC. Population-Based Assessment of Determining Treatments for Prostate Cancer. JAMA Oncol. 2015;1(1):60-7.
    Chamie, K., Williams, S. B., & Hu, J. C. (2015). Population-Based Assessment of Determining Treatments for Prostate Cancer. JAMA Oncology, 1(1), pp. 60-7. doi:10.1001/jamaoncol.2014.192.
    Chamie K, Williams SB, Hu JC. Population-Based Assessment of Determining Treatments for Prostate Cancer. JAMA Oncol. 2015;1(1):60-7. PubMed PMID: 26182305.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Population-Based Assessment of Determining Treatments for Prostate Cancer. AU - Chamie,Karim, AU - Williams,Stephen B, AU - Hu,Jim C, PY - 2015/7/17/entrez PY - 2015/7/17/pubmed PY - 2016/4/2/medline SP - 60 EP - 7 JF - JAMA oncology JO - JAMA Oncol VL - 1 IS - 1 N2 - IMPORTANCE: Many men with indolent prostate cancer often opt for radical prostatectomy or radiotherapy treatment for their disease. These men may experience considerable detriments of quality of life owing to sexual, urinary, and/or rectal toxic effects associated with these treatments. Without a better understanding of the mutable agents and predictors of treatment types, diffusion of expectant management among these men will be slow. OBJECTIVE: To determine population-based predictors for treatment and use of watchful waiting or active surveillance for indolent prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: We used Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. A total of 37,621 men in the general community diagnosed as having prostate cancer from 2004 to 2007 were followed until December 31, 2009. EXPOSURES: Watchful waiting or active surveillance, radiation therapy, or radical prostatectomy. MAIN OUTCOMES AND MEASURES: We used mixed-effects logistic regression analysis to determine the factors associated with aggressive treatment and use of watchful waiting or active surveillance for men with prostate cancer. RESULTS: The most common treatment type is radiation therapy (57.9% [95% CI, 57.4%-58.4%]), followed by radical prostatectomy (19.1% [95% CI, 18.7%-19.5%]) and watchful waiting or active surveillance (9.6% [95% CI, 9.3%-9.9%]). Moreover, patients and providers significantly integrate age (odds ratio [OR], 0.32 [95% CI, 0.29-0.35]) and comorbidities (OR, 0.62 [95% CI, 0.56-0.68]) when determining radical prostatectomy, while regional variation (OR, 0.57 [95% CI, 0.47-0.68]) and referral patterns (OR, 44.46 [95% CI, 41.04-48.17]) influence the use of radiation therapy. Patient demographics and tumor characteristics significantly account for 40% of patients undergoing prostatectomy, 12% choosing watchful waiting or active surveillance, and only 3% undergoing radiotherapy. CONCLUSIONS AND RELEVANCE: There is increased use of radiotherapy among patients with indolent prostate cancer with limited to no correlation with tumor biology. Active surveillance was underused, and a significant proportion of the variance was unexplained. Further research into qualitatively describing the contributing factors that drive decision-making recommendations for prostate cancer patients is needed. SN - 2374-2445 UR - https://www.unboundmedicine.com/medline/citation/26182305/Population_Based_Assessment_of_Determining_Treatments_for_Prostate_Cancer_ L2 - https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2014.192 DB - PRIME DP - Unbound Medicine ER -