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Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study.

Abstract

Classic Hodgkin lymphoma (cHL) has few known modifiable risk factors, and the relationship between diet and cHL risk is unclear. We performed the first investigation of an association between dietary pattern and cHL risk in 435 cHL cases and 563 population-based controls from Massachusetts and Connecticut (1997-2000) who completed baseline diet questionnaires. We identified 4 major dietary patterns ("vegetable," "high meat," "fruit/low-fat dairy," "desserts/sweets") using principal components analysis. We computed multivariable odds ratios and 95% confidence intervals for associations of dietary pattern score (quartiles) with younger-adult (age <50 years), older-adult (age ≥50 years), and overall cHL risk. Secondary analyses examined associations by histological subtype and tumor Epstein-Barr virus (EBV) status. A diet high in desserts/sweets was associated with younger-adult (odds ratio(quartile 4 vs. quartile 1) = 1.60, 95% confidence interval: 1.05, 2.45; Ptrend = 0.008) and EBV-negative, younger-adult (odds ratio = 2.11, 95% confidence interval: 1.31, 3.41; Ptrend = 0.007) cHL risk. A high meat diet was associated with older-adult (odds ratio = 3.34, 95% confidence interval: 1.02, 10.91; Ptrend = 0.04) and EBV-negative, older-adult (odds ratio = 4.64, 95% confidence interval: 1.03, 20.86; Ptrend = 0.04) cHL risk. Other dietary patterns were not clearly associated with cHL. We report the first evidence for a role of dietary pattern in cHL etiology. Diets featuring high intake of meat or desserts and sweets may increase cHL risk.

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  • Authors

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    Source

    American journal of epidemiology 182:5 2015 Sep 01 pg 405-16

    MeSH

    Adolescent
    Adult
    Body Mass Index
    Case-Control Studies
    Connecticut
    Diet
    Feeding Behavior
    Female
    Fruit
    Health Behavior
    Herpesvirus 4, Human
    Hodgkin Disease
    Humans
    Life Style
    Male
    Massachusetts
    Meat
    Middle Aged
    Odds Ratio
    Risk Factors
    Socioeconomic Factors
    Vegetables
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26182945

    Citation

    Epstein, Mara M., et al. "Dietary Pattern and Risk of Hodgkin Lymphoma in a Population-based Case-control Study." American Journal of Epidemiology, vol. 182, no. 5, 2015, pp. 405-16.
    Epstein MM, Chang ET, Zhang Y, et al. Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study. Am J Epidemiol. 2015;182(5):405-16.
    Epstein, M. M., Chang, E. T., Zhang, Y., Fung, T. T., Batista, J. L., Ambinder, R. F., ... Birmann, B. M. (2015). Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study. American Journal of Epidemiology, 182(5), pp. 405-16. doi:10.1093/aje/kwv072.
    Epstein MM, et al. Dietary Pattern and Risk of Hodgkin Lymphoma in a Population-based Case-control Study. Am J Epidemiol. 2015 Sep 1;182(5):405-16. PubMed PMID: 26182945.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary pattern and risk of hodgkin lymphoma in a population-based case-control study. AU - Epstein,Mara M, AU - Chang,Ellen T, AU - Zhang,Yawei, AU - Fung,Teresa T, AU - Batista,Julie L, AU - Ambinder,Richard F, AU - Zheng,Tongzhang, AU - Mueller,Nancy E, AU - Birmann,Brenda M, Y1 - 2015/07/15/ PY - 2014/09/09/received PY - 2015/03/18/accepted PY - 2015/7/18/entrez PY - 2015/7/18/pubmed PY - 2015/12/15/medline KW - Hodgkin lymphoma KW - case-control study KW - diet KW - principal components analysis SP - 405 EP - 16 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 182 IS - 5 N2 - Classic Hodgkin lymphoma (cHL) has few known modifiable risk factors, and the relationship between diet and cHL risk is unclear. We performed the first investigation of an association between dietary pattern and cHL risk in 435 cHL cases and 563 population-based controls from Massachusetts and Connecticut (1997-2000) who completed baseline diet questionnaires. We identified 4 major dietary patterns ("vegetable," "high meat," "fruit/low-fat dairy," "desserts/sweets") using principal components analysis. We computed multivariable odds ratios and 95% confidence intervals for associations of dietary pattern score (quartiles) with younger-adult (age <50 years), older-adult (age ≥50 years), and overall cHL risk. Secondary analyses examined associations by histological subtype and tumor Epstein-Barr virus (EBV) status. A diet high in desserts/sweets was associated with younger-adult (odds ratio(quartile 4 vs. quartile 1) = 1.60, 95% confidence interval: 1.05, 2.45; Ptrend = 0.008) and EBV-negative, younger-adult (odds ratio = 2.11, 95% confidence interval: 1.31, 3.41; Ptrend = 0.007) cHL risk. A high meat diet was associated with older-adult (odds ratio = 3.34, 95% confidence interval: 1.02, 10.91; Ptrend = 0.04) and EBV-negative, older-adult (odds ratio = 4.64, 95% confidence interval: 1.03, 20.86; Ptrend = 0.04) cHL risk. Other dietary patterns were not clearly associated with cHL. We report the first evidence for a role of dietary pattern in cHL etiology. Diets featuring high intake of meat or desserts and sweets may increase cHL risk. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/26182945/Dietary_pattern_and_risk_of_hodgkin_lymphoma_in_a_population_based_case_control_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwv072 DB - PRIME DP - Unbound Medicine ER -