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Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms.
Arch Gerontol Geriatr. 2015 Nov-Dec; 61(3):517-22.AG

Abstract

BACKGROUND

Nonmotor symptoms in Parkinson's disease (PD) are heterogeneous and can result in a variety of symptoms at various disease stages. The objective of the present study was to identify clinically meaningful nonmotor symptoms and to assess the relationship between changes in nonmotor symptoms and cognition and motor symptoms.

METHODS

A total of 159 patients who had drug-naïve PD participated in this study. Nonmotor symptoms (Nonmotor Symptoms Scale), PD status (Unified Parkinson's Disease Rating Scale), depression (Geriatric Depression Scale or Montgomery-Asberg Depression Scale) and health-related quality of life (39-item Parkinson's Disease Questionnaire) were assessed. An exploratory factor analysis was performed to establish a nonmotor symptom factor, which was analyzed to evaluate whether the results were associated with the clinical severity measures.

RESULTS

Exploratory factor analysis revealed one factor comprised of sleep/fatigue, attention/memory and mood/cognition. The modified Hoehn and Yahr Stage, Unified Parkinson's Disease Rating Scale Part III, Montgomery-Asberg Depression Scale and the 39-item Parkinson's Disease Questionnaire Summary Index were independently associated with the sleep/fatigue, attention/memory and mood/cognition domains. The presence of these domains was associated with advanced Parkinson's disease or depressed mood.

CONCLUSIONS

This study shows that motor impairment and depressed mood in PD are related to sleep/fatigue, attention/memory and mood/cognition. Sleep/fatigue, attention/memory and mood/cognition also had a major impact on health-related quality of life. It is appropriate to identify patients with severe motor symptoms and depressed mood in order to signify the need to consider more detailed care and further assessment.

Authors+Show Affiliations

Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea.Department of Information Statistics, Kangwon National University College of Natural Sciences, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, Republic of Korea.Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea.Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea.Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea.Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea.Department of Neurology and Parkinson's disease Centre, Korea University College of Medicine at Guro Hospital, 148 Gurodong-Road, Guro-Ku, Seoul 152-703, Republic of Korea. Electronic address: parkinson@korea.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26183203

Citation

Lee, Hye Mi, et al. "Clinical Phenotype of Drug-naïve Parkinson's Disease Based On Nonmotor Symptoms." Archives of Gerontology and Geriatrics, vol. 61, no. 3, 2015, pp. 517-22.
Lee HM, Lee SS, Kim M, et al. Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms. Arch Gerontol Geriatr. 2015;61(3):517-22.
Lee, H. M., Lee, S. S., Kim, M., Kang, S. H., Seo, W. K., Kim, J. H., & Koh, S. B. (2015). Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms. Archives of Gerontology and Geriatrics, 61(3), 517-22. https://doi.org/10.1016/j.archger.2015.07.001
Lee HM, et al. Clinical Phenotype of Drug-naïve Parkinson's Disease Based On Nonmotor Symptoms. Arch Gerontol Geriatr. 2015 Nov-Dec;61(3):517-22. PubMed PMID: 26183203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms. AU - Lee,Hye Mi, AU - Lee,Seung-Soo, AU - Kim,Minjik, AU - Kang,Sung Hoon, AU - Seo,Woo-Keun, AU - Kim,Ji Hyun, AU - Koh,Seong-Beom, Y1 - 2015/07/06/ PY - 2014/05/03/received PY - 2014/09/25/revised PY - 2015/07/03/accepted PY - 2015/7/18/entrez PY - 2015/7/18/pubmed PY - 2016/2/16/medline KW - Attention KW - Exploratory factor analysis KW - Mood KW - Nonmotor symptoms KW - Parkinson’s disease KW - Sleep SP - 517 EP - 22 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 61 IS - 3 N2 - BACKGROUND: Nonmotor symptoms in Parkinson's disease (PD) are heterogeneous and can result in a variety of symptoms at various disease stages. The objective of the present study was to identify clinically meaningful nonmotor symptoms and to assess the relationship between changes in nonmotor symptoms and cognition and motor symptoms. METHODS: A total of 159 patients who had drug-naïve PD participated in this study. Nonmotor symptoms (Nonmotor Symptoms Scale), PD status (Unified Parkinson's Disease Rating Scale), depression (Geriatric Depression Scale or Montgomery-Asberg Depression Scale) and health-related quality of life (39-item Parkinson's Disease Questionnaire) were assessed. An exploratory factor analysis was performed to establish a nonmotor symptom factor, which was analyzed to evaluate whether the results were associated with the clinical severity measures. RESULTS: Exploratory factor analysis revealed one factor comprised of sleep/fatigue, attention/memory and mood/cognition. The modified Hoehn and Yahr Stage, Unified Parkinson's Disease Rating Scale Part III, Montgomery-Asberg Depression Scale and the 39-item Parkinson's Disease Questionnaire Summary Index were independently associated with the sleep/fatigue, attention/memory and mood/cognition domains. The presence of these domains was associated with advanced Parkinson's disease or depressed mood. CONCLUSIONS: This study shows that motor impairment and depressed mood in PD are related to sleep/fatigue, attention/memory and mood/cognition. Sleep/fatigue, attention/memory and mood/cognition also had a major impact on health-related quality of life. It is appropriate to identify patients with severe motor symptoms and depressed mood in order to signify the need to consider more detailed care and further assessment. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/26183203/Clinical_phenotype_of_drug_naïve_Parkinson's_disease_based_on_nonmotor_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(15)30027-3 DB - PRIME DP - Unbound Medicine ER -