Tags

Type your tag names separated by a space and hit enter

Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis.
Z Rheumatol. 2015 Oct; 74(8):714-21.ZR

Abstract

OBJECTIVE

The purpose of this work was to investigate whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to Behcet's disease (BD).

METHODS

A meta-analysis was conducted on the associations between the MICA-transmembrane (TM) A6 allele and the 009 allele of MICA exon 2-4 (MICA*009) and BD with or without HLA-B51 overall and in each ethnic group.

RESULTS

Fifteen comparison studies were included in this meta-analysis. The meta-analysis revealed a significant association between the MICA-TM A6 allele and BD in European, Asian, and Arab populations [odds ratio (OR) 1.436, 95 % confidence interval (CI) 1.111-1.857, p = 0.006; OR 1.999, 95 % CI 1.551-2.575, p = 8.0 × 10(-8); OR 1.333, 95 % CI 1.058-2.300, p = 0.025, respectively,]). Stratification by HLA-B51 showed an association between the MICA-TM A6 allele and BD with HLA-B51 in the overall group and in the European population. Meta-analysis showed a significant association between the MICA*009 allele and BD in the overall group (OR 3.948, 95 % CI 2.680-5.815, p < 1.0 × 10(-8)) and in the European population (OR 3.392, 95 % CI 2.118-5.433, p = 5.6 × 10(-6)). A significant association was found between the MICA*009 allele and B51-positive BD.

CONCLUSION

This meta-analysis shows that the MICA-TM A6 allele and the MICA*009 allele are associated with BD susceptibility in various ethnic populations, and that MICA alleles are in strong linkage disequilibrium with HLA-B51 in BD.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea. lyhcgh@korea.ac.kr.Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

26184953

Citation

Lee, Y H., and G G. Song. "Associations Between Major Histocompatibility Complex Class I Chain-related Gene a Polymorphisms and Susceptibility to Behcet's Disease. a Meta-analysis." Zeitschrift Fur Rheumatologie, vol. 74, no. 8, 2015, pp. 714-21.
Lee YH, Song GG. Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis. Z Rheumatol. 2015;74(8):714-21.
Lee, Y. H., & Song, G. G. (2015). Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis. Zeitschrift Fur Rheumatologie, 74(8), 714-21. https://doi.org/10.1007/s00393-014-1536-3
Lee YH, Song GG. Associations Between Major Histocompatibility Complex Class I Chain-related Gene a Polymorphisms and Susceptibility to Behcet's Disease. a Meta-analysis. Z Rheumatol. 2015;74(8):714-21. PubMed PMID: 26184953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease. A meta-analysis. AU - Lee,Y H, AU - Song,G G, PY - 2015/7/18/entrez PY - 2015/7/18/pubmed PY - 2016/7/19/medline KW - Behcet syndrome KW - HLA-B51 antigen KW - Histocompatibility antigens class I KW - MICA KW - Polymorphism, genetic SP - 714 EP - 21 JF - Zeitschrift fur Rheumatologie JO - Z Rheumatol VL - 74 IS - 8 N2 - OBJECTIVE: The purpose of this work was to investigate whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to Behcet's disease (BD). METHODS: A meta-analysis was conducted on the associations between the MICA-transmembrane (TM) A6 allele and the 009 allele of MICA exon 2-4 (MICA*009) and BD with or without HLA-B51 overall and in each ethnic group. RESULTS: Fifteen comparison studies were included in this meta-analysis. The meta-analysis revealed a significant association between the MICA-TM A6 allele and BD in European, Asian, and Arab populations [odds ratio (OR) 1.436, 95 % confidence interval (CI) 1.111-1.857, p = 0.006; OR 1.999, 95 % CI 1.551-2.575, p = 8.0 × 10(-8); OR 1.333, 95 % CI 1.058-2.300, p = 0.025, respectively,]). Stratification by HLA-B51 showed an association between the MICA-TM A6 allele and BD with HLA-B51 in the overall group and in the European population. Meta-analysis showed a significant association between the MICA*009 allele and BD in the overall group (OR 3.948, 95 % CI 2.680-5.815, p < 1.0 × 10(-8)) and in the European population (OR 3.392, 95 % CI 2.118-5.433, p = 5.6 × 10(-6)). A significant association was found between the MICA*009 allele and B51-positive BD. CONCLUSION: This meta-analysis shows that the MICA-TM A6 allele and the MICA*009 allele are associated with BD susceptibility in various ethnic populations, and that MICA alleles are in strong linkage disequilibrium with HLA-B51 in BD. SN - 1435-1250 UR - https://www.unboundmedicine.com/medline/citation/26184953/Associations_between_major_histocompatibility_complex_class_I_chain_related_gene_A_polymorphisms_and_susceptibility_to_Behcet's_disease__A_meta_analysis_ L2 - https://dx.doi.org/10.1007/s00393-014-1536-3 DB - PRIME DP - Unbound Medicine ER -