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Immunosuppressive C₂₁ steroidal glycosides from the root of Cynanchum atratum.
Fitoterapia. 2015 Sep; 105:194-201.F

Abstract

Six new C21 steroidal glycosides (1-6) and one dideoxysaccharide (7), named atratcynosides A-F and atratcynose A, were isolated from the 80% ethanol extract of the root of Cynanchum atratum, together with three known compounds (8-10). The structures of the new compounds were determined on the basis of extensive spectral analyses and qualitative chemical methods. All compounds were subjected to detect the immunosuppressive activities by an in vitro model of concanavalin A-induced proliferation of T-lymphocytes from mice. Compounds 1-3 showed significant immunosuppressive activities in dose-dependent manners with the IC50 values from 3.3 to 7.0 μM. Moreover, the structure-activity relationship of the steroidal glycosides on the immunosuppression was analyzed.

Authors+Show Affiliations

State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China.State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China.State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China.State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China. Electronic address: mianzhang@126.com.State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China.State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy China Pharmaceutical University, Longmian Road 639, Nanjing 211198, PR China. Electronic address: njchaofeng@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26186991

Citation

Zhang, Zhi-Jun, et al. "Immunosuppressive C₂₁ Steroidal Glycosides From the Root of Cynanchum Atratum." Fitoterapia, vol. 105, 2015, pp. 194-201.
Zhang ZJ, Ding ML, Tao LJ, et al. Immunosuppressive C₂₁ steroidal glycosides from the root of Cynanchum atratum. Fitoterapia. 2015;105:194-201.
Zhang, Z. J., Ding, M. L., Tao, L. J., Zhang, M., Xu, X. H., & Zhang, C. F. (2015). Immunosuppressive C₂₁ steroidal glycosides from the root of Cynanchum atratum. Fitoterapia, 105, 194-201. https://doi.org/10.1016/j.fitote.2015.07.010
Zhang ZJ, et al. Immunosuppressive C₂₁ Steroidal Glycosides From the Root of Cynanchum Atratum. Fitoterapia. 2015;105:194-201. PubMed PMID: 26186991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunosuppressive C₂₁ steroidal glycosides from the root of Cynanchum atratum. AU - Zhang,Zhi-Jun, AU - Ding,Mei-Ling, AU - Tao,Li-Jun, AU - Zhang,Mian, AU - Xu,Xiang-Hong, AU - Zhang,Chao-Feng, Y1 - 2015/07/14/ PY - 2015/05/20/received PY - 2015/07/07/revised PY - 2015/07/08/accepted PY - 2015/7/19/entrez PY - 2015/7/19/pubmed PY - 2015/12/15/medline KW - C(21) steroidal glycosides KW - Cynanchum atratum KW - Immunosuppressive KW - Structure–activity relationship SP - 194 EP - 201 JF - Fitoterapia JO - Fitoterapia VL - 105 N2 - Six new C21 steroidal glycosides (1-6) and one dideoxysaccharide (7), named atratcynosides A-F and atratcynose A, were isolated from the 80% ethanol extract of the root of Cynanchum atratum, together with three known compounds (8-10). The structures of the new compounds were determined on the basis of extensive spectral analyses and qualitative chemical methods. All compounds were subjected to detect the immunosuppressive activities by an in vitro model of concanavalin A-induced proliferation of T-lymphocytes from mice. Compounds 1-3 showed significant immunosuppressive activities in dose-dependent manners with the IC50 values from 3.3 to 7.0 μM. Moreover, the structure-activity relationship of the steroidal glycosides on the immunosuppression was analyzed. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/26186991/Immunosuppressive_C₂₁_steroidal_glycosides_from_the_root_of_Cynanchum_atratum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(15)30049-6 DB - PRIME DP - Unbound Medicine ER -